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Carotenoid Compound Coming From Plant And Containing Natural Astaxanthin, Preparation Method Therefor, And Composition

a technology of astaxanthin and plant, which is applied in the field of astaxanthin compounds, can solve the problems of synthetic astaxanthin not being able to be converted into natural astaxanthin in animal bodies, the effect of biological absorption and pigmentation of synthetic astaxanthin is also worse than that of natural astaxanthin, and the purity of synthetic astaxanthin cannot be reduced. , to achieve the effect of increasing separation efficiency, reducing the purity of synthetic astaxan

Inactive Publication Date: 2016-11-17
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a method for producing astaxanthin, a valuable pigment, using a specific concentration of alkali solution. The concentration of the alkali solution is critical, as it affects the efficiency of the reaction and the purity of the final product. The preferred concentration is 0.01-2.50 mol / L. The astaxanthin can be applied in different forms, such as oil or powder, and can be embedded in microcapsules for better stability. The technical effects of this patent are improved efficiency and purity of astaxanthin production.

Problems solved by technology

Astaxanthin prepared by chemical synthesis is expensive and has significant differences in molecular structures, biological functions, application effects and biological safeties.
Synthetic astaxanthin obviously has stability and antioxidant activity lower than that of natural astaxanthin, and the effects of biological absorption and pigmentation of synthetic astaxanthin are also worse than that of natural astaxanthin.
And synthetic astaxanthin can not be converted into natural astaxanthin in animal bodies.
On the other hand, pollutions and impurities are inevitably produced in the process of synthesis, which can lead to generation of some potential safety hazard and reduction of safety performance.
Wherein the bacteria thalli has basically no use value because of its slow growth and low synthesis.
However, it is difficult to establish a stable and efficient production technology system, because the Haematococcus pluvialis is sensitive to environment, and susceptible to protozoa and bacterial contamination.
Consequently it increases production costs and is adverse to commercial production.
Many factors restrict astaxanthin extraction including shellfish waste such as shrimp shell being perishable, large volume, relatively high transportation cost, low content levels of astaxanthin with large changes, binding state of astaxanthin, particle size shell, etc.
No better method with industrial scales of producing astaxanthin from these wastes has been found at present.
However, it would be difficult to realize large-scale production because of some deficiencies such as culture conditions, high costs, and difficult extraction conditions.
Astaxanthin is a very unstable substance, with high antioxidant activity, and is very easily oxidized to semi-astacene under the conditions of alkaline environment or oxygen or heating, thereby affecting its bioactivity.

Method used

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  • Carotenoid Compound Coming From Plant And Containing Natural Astaxanthin, Preparation Method Therefor, And Composition
  • Carotenoid Compound Coming From Plant And Containing Natural Astaxanthin, Preparation Method Therefor, And Composition
  • Carotenoid Compound Coming From Plant And Containing Natural Astaxanthin, Preparation Method Therefor, And Composition

Examples

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Effect test

example 1

[0058]Fifty (50) g (UV content is 10.5 wt %) of Adonis amurensis extract (Adonis amurensis extract is obtained by extracting Adonis amurensis dried granules with a mixture of propane and butane and then is volatilized) is added to 2500 ml of absolute ethanol, heated to 75° C. under stirring, and kept for 1.0 hr to fully dissolve the Adonis amurensis extract. Next, 432 ml of NaOH solution with 45% of the mass concentration (w / w) is added dropwise to form a reaction mixture solution, and the alkali concentration of the reaction mixture solution is 2.0 mol / L after completion of the addition, and stirred at 75° C. for 4.0 hr. Next, 5000 ml of deionized water and 1000 ml of ethanol are added to it, and then a dark red crystal is precipitated after slowly stirring for 1.0 hr. After filtration, the resulting filter cake is washed with a mixture of ethanol and deionized water (the ratio of ethanol to deionized water is 2:1) twice, 600 ml of the mixture of ethanol and deionized water per tim...

example 2

[0063]100 g of Adonis amurensis extract (UV content is 10.5 wt %) is added to 3000 ml of glycerol, heated to 60° C. under stirring, and kept for 1.0 hr to fully dissolve the Adonis amurensis extract. 1000 ml of CH3ONa solution with the mass concentration of 25% (w / w) is added dropwise to form a reaction mixture solution, and the alkali concentration of the reaction mixture solution is 1.16 mol / L, and stirred at 60° C. for 0.5 hr. 6000 ml of deionized water and 1000 ml glycerol is added to it, and then a dark red crystal is precipitated after slowly stirring for 1.0 hr. After filtration, the filter cake is washed with a mixture of glycerol and deionized water (the ratio of glycerine and deionized water is 3:1) for twice, 500 ml of the mixture of glycerol and deionized water per time, to obtain a crystal, the crystal is dried in vacuum, to eventually obtain 4.8 g of a dark purple carotenoid crystal.

[0064]Its maximum absorption wavelength of the carotenoid crystal by UV detection is at...

example 3

[0066]100 kg adonis amurensis extract (UV content is 10.5 wt %) is added to 5000 L of propylene glycol, and is fully dispersed under stirring at 25° C. 123 L of KOH solution with a mass concentration of 25% (w / w) is added dropwise, and is stirred at 25° C. for 2.5 hr. After sampling and analysis with HPLC, it is found that the reaction is not complete, and the reaction is continued for 3.5 hr. After completion of the reaction monitored by HPLC, 5000 L of deionized water and 500 L of propylene glycol are added to it to terminate the reaction. After stirring slowly for 1.0 hr, a dark red crystal is precipitated. After filtration by pressure, a filter cake is washed with a mixture of propylene alcohol and deionized water (the ratio of propylene alcohol to water is 2:1) twice, 600 ml of the mixture of propylene alcohol and deionized water per time, to obtain a crystal, the crystal is dried in vacuum, to eventually obtain 6.8 Kg of a dark purple carotenoid crystal.

[0067]Its maximum absor...

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Abstract

The present invention provides a high-content carotenoid compound from adonis amurensis. The content of the total carotenoid of the carotenoid compound is greater than 95%. The content of all-trans (3S, 3′S)-carotenoid is greater than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a national phase application of PCT / CN2014 / 000862, filed on Sep. 23, 2014, which claims priority to Chinese Application No. 201310440119.6 filed on Sep. 24, 2013.FIELD OF THE INVENTION[0002]The present invention relates to a carotenoid compound coming from plant extract with less impurity containing natural astaxanthin with high biological activities, and its preparation method and composition, and relates to the field of biochemistry.BACKGROUD OF THE INVENTION[0003]Astaxanthin's formula is C40H52O4 and is referred to as 3,3′-dihydroxy-4,4′-diketo-β,β′-carotene, widely exists in nature, is an important substance of carotenoid, and has a higher physiological activity than other carotenoids. The molecular formula is as follows:[0004]As for a kind of natural preparation, astaxanthin has broader uses and development prospects in various industries such as pharmaceuticals, aquaclutures, foods, chemistries.[0005]Astaxanthin ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/122C07C403/24A61K36/71
CPCA61K31/122A61K36/71C07C403/24C07C2101/16A61K2236/37A61K2236/53A61K2236/51A61K2236/33A61Q19/00A61K2800/10A61K2800/43A23K20/179A23L33/105C07C2601/14C07C2601/16A61K8/9789
Inventor XU, XINDESHAO, BINPENG, YONGJIANWANG, SHENGNAN
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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