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Process for preparing microcapsules

a microcapsule and slurry technology, applied in the direction of biocide, perfume formulation, detergent compounding agent, etc., can solve the problems of odoriferous compound loss relative to rapid, fragranced personal and household cleansers containing high levels of aggressive surfactant detergents, and difficult stability of microcapsules, so as to achieve good performance and not compromise the performance of microcapsules

Pending Publication Date: 2022-03-10
FIRMENICH SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a new process for preparing microcapsules that can protect and release perfume over time. These microcapsules are stable in challenging bases, such as personal care products, and can deliver a good performance in terms of active ingredient delivery. The process involves dissolving a polyisocyanate in a perfume oil to form an oil phase, and adding a stabilizer to create a dispersing phase. The two phases are then mixed together to form a slurry. The resulting microcapsules have excellent stability and can be used in perfuming compositions.

Problems solved by technology

One of the problems faced by the perfumery industry lies in the relatively rapid loss of olfactive benefit provided by odoriferous compounds due to their volatility, particularly that of “top-notes”.
For instance, fragranced personal and household cleansers containing high levels of aggressive surfactant detergents are very challenging for the stability of microcapsules.

Method used

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  • Process for preparing microcapsules
  • Process for preparing microcapsules
  • Process for preparing microcapsules

Examples

Experimental program
Comparison scheme
Effect test

example 1

Microcapsules Preparation According to the Invention

Protocol

General Protocol of Lysine Triisocyanate Purification

[0240]Raw L-lysine triisocyanate (LTI—20 g—Watson International LTD) is weighed into a flask covered with the alumina foil and combined with methyl tert-butyl ether (150 mL). Activated carbon (4 grams) is added and the mixture is stirred for 30 minutes. The mixture is filtered and the filtrate is isolated and concentrated under reduced pressure in a rotavap to give amber oil.

General Protocol for Capsule Synthesis:

[0241]The purified LTI (light brown oil, 3 g) (with optionally Takenate® D110N) was dissolved in 30 g of a perfume oil (perfume oil A for capsules A-D or perfume oil B for capsules E—see respectively Table A and Table B). The oil phase was then added to an aqueous solution (37 g) comprising a stabilizer (1% gum arabic solution) and homogenized for 4 min using an Ultra-Turrax T25 disperser at 24000 rpm to form an O / W emulsion. The emulsion was pH adjusted to 10 us...

example 2

Stability of Microcapsules in a Shower Gel

[0245]Capsules slurry A (450 mg) or capsule slurry E (450 mg) has been introduced in a shower gel base (10 g) having the composition described in Table 6 (for Capsule slurry A) or Table 7 (for Capsule slurry E) leading to 1.4% of perfume oil in the sample.

TABLE 6Shower gel base composition AIngredientsQuantityDeionized water56.85EDETA B Powder0.05Glydant Plus Liquid0.21,2-Propylene Glycol2TEXAPON NSO IS27Citric Acid 20% aqueous solution1CREMOPHOR RH 401Perfume1Sodium Chloride0.7Sodium Benzoate0.25Sodium Salicylate0.25MERQUAT 5500.2Glucamate LT1.5TEGO BETAIN F 508

TABLE 7Shower gel base composition BIngredientsQuantityDeionized water49.35EDETA B Powder0.05CARBOPOL AQUA SF-1 POLYMER0.20Zetesol AO 328 U35.00SODIUM HYDROXIDE 20% aqueous solution1.00TEGO-BETAIN F 508.00KATHON CG0.10Citric Acid (40%)0.50

[0246]The amount of perfume having leaked out of the capsules was then measured by solvent extraction and GC-FID analysis (Table 8 and 9).

TABLE 8Le...

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Abstract

Described herein are a process for the preparation of a microcapsule slurry, and the microcapsule slurry. Perfuming compositions and consumer products including the microcapsule slurry, in particular perfumed consumer products in the form of home care or personal care products, are also described.

Description

TECHNICAL FIELD[0001]The present invention relates to a new process for the preparation of a microcapsule slurry. A microcapsule slurry is also an object of the invention. Perfuming compositions and consumer products comprising said microcapsule slurry, in particular perfumed consumer products in the form of home care or personal care products, are also part of the invention.BACKGROUND OF THE INVENTION[0002]One of the problems faced by the perfumery industry lies in the relatively rapid loss of olfactive benefit provided by odoriferous compounds due to their volatility, particularly that of “top-notes”. In order to tailor the release rates of volatiles, delivery systems such as microcapsules containing a perfume are needed to protect and later release the core payload when triggered. A key requirement from the industry regarding these systems is to survive suspension in challenging bases without physically dissociating or degrading. This is referred to as stability for the delivery ...

Claims

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Application Information

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IPC IPC(8): B01J13/16C11D3/50C11D3/37
CPCB01J13/16C11D3/3726C11D3/505A01N25/28A61K8/11B01J13/14A61K2800/412A61K8/87A61Q13/00A61Q19/10
Inventor MA, LINGFENG, JINGYUOUALI, LAHOUSSINEJERRI, HUDA
Owner FIRMENICH SA
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