The invention belongs to the field of fire fighting and dedusting and mainly aims at providing a pressure-sensing self-sealing atomization nozzle. When an existing nozzle works in a dust floating airflow environment, intermittent spraying occurs frequently, floating dust enters the interior of the nozzle and deposits in the nozzle when the nozzle stops working, and consequentially, the nozzle is blocked and fails to work normally. To solve the problem, the pressure-sensing self-sealing atomization nozzle is provided, when the pressure of fluid is decreased, the nozzle automatically closes gapsfor spraying liquid, the interior of the nozzle is isolated from the exterior, and dust is prevented from entering the nozzle. The pressure-sensing self-sealing atomization nozzle provided by the invention is mainly composed of two portions including a head module and a rotary rack, the two portions are assembled through threads, the head module is composed of a nozzle module, a base, a propeller, a slip ring, a spring, a screw, blocking pieces and a spiral head, and the rotary rack is composed of a retainer ring, a seal ring, a thrust bearing, a shell, a support, a water feeding pipe, a deepgroove ball bearing and a quick coupling.