The invention discloses a compound weeding composition. Effective components of the compound weeding composition include dicamba, agroxone and pinoxaden, wherein a weight ratio of dicamba to agroxone to pinoxaden is 0.5-5: 1-15: 1-30; besides, the compound weeding composition also contains a dispersing agent, an emulsifier, a wetting agent, an antifreezing agent, a thickening agent, a disintegrating agent, a binder, filler, a solvent and other auxiliaries; the dosage form of the compound weeding composition can be wettable powder, suspending agent, water dispersing granules and emulsion oil. The weeding effect of the compound weeding composition is significantly improved by comparing with that of single dosage, and the compound weeding composition can be applied to prevention and elimination of broad-leaf weed, nutgrass flatsedge and grassy weed in wheat fields; thus the compound weeding composition can enlarge herbicide controlling spectrum, improve prevention effects, retard weed resistance, reduce consumption of dicamba, decrease using cost, and improve wheat safety.