The invention relates to the field of indoor air purification devices, in particular to a cleaning assembly for a ventilation pipeline of an indoor air purification device, which comprises a main body, an opening and closing mechanism, a filtering mechanism, a limiting mechanism, a cleaning mechanism and an auxiliary mechanism. By arranging the filtering mechanism, the quality of air entering a room can be guaranteed, filtering accessories such as a filter element are convenient to replace, the using effect of the device is improved, the filtering mechanism is convenient to open and close automatically by arranging the opening and closing mechanism, and the replacement efficiency of the filtering mechanism is improved in an assisted mode. By arranging the cleaning mechanism, the inner wallof the pipeline can be conveniently and automatically cleaned, manpower and time are saved, the cleaning efficiency is improved, by arranging the limiting mechanism, dust filtering components can beconveniently replaced, airflow circulation in the main body is guaranteed, dust is prevented from entering the device, and the cleanliness of the interior of the device are guaranteed; Through the arrangement of the auxiliary mechanism, the filtering part is conveniently limited and fixed in an auxiliary manner and is prevented from accidentally separating from a limiting position.