The invention relates to the technical field of cargo locking, in particular to a lateral high-load impact resistant cargo locking device. The device comprises a first mounting base (1), a first limiting block (2), a first connecting rod (3), a second mounting base (4), a second connecting rod (5), a second limiting block (6), a third connecting rod (7), a third mounting base (8), a locking block (9), a third limiting block (10), a locking in-place switch (11), a sliding block (12), an unlocking in-place switch (13), a fourth limiting block (14) and a rotating motor (15). Through the lateral high-load impact resistant cargo locking device, lateral high-load impact resistant cargos are locked and gathered in one simple device, so that the cost is lowered, the reliability is high, and locking of the lateral high-load impact resistant cargos is realized. The lateral high-load impact resistant cargo locking device is simple and firm in structure, high in reliability, convenient to use and free from external condition restrictions.