The invention belongs to the technical field of
organic synthesis, and particularly relates to a
quaternary carbon type chiral allyl gem-
silicon-
boron compound as well as a synthesis method and application thereof, the
structural formula of the
quaternary carbon type chiral allyl gem-
silicon-
boron compound is # imgabs0 #, and the
quaternary carbon type chiral allyl gem-
silicon-
boron compound can be used as a novel allyl bimetallic
reagent to be subjected to an allyl boronation reaction to obtain the
quaternary carbon type chiral allyl gem-silicon-boron compound. An E-anti homoallylic
alcohol structural framework is obtained through complete double-bond selectivity and excellent diastereoselectivity, and compared with an existing synthesis method of a trisubstituted olefin-containing homoallylic
alcohol structural building block, the method has the advantages of simple steps, high synthesis efficiency, wide application range and remarkable stereochemical control
advantage; the building block has a wide application prospect for natural products or
drug intermediates with the building block with the structure. When the
quaternary carbon type chiral allyl gem-silicon boron compound is applied to allyl boronation reaction, the
quaternary carbon type chiral allyl gem-silicon boron compound has the advantages of high synthesis efficiency, wide substrate applicability, excellent selectivity, high yield and low synthesis cost.