Calf-blood deprotein capsules and preparation thereof

A protein-free and calf blood technology, which is applied in capsule delivery, skin diseases, medical raw materials derived from mammals, etc., can solve the problems of inconvenient use, enteric-coated tablets are not as stable as enteric-coated capsules, and cannot be administered systemically , to achieve the effect of overcoming instability and remarkable curative effect

Active Publication Date: 2008-01-09
JINZHOU AHON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, calf blood deproteinized products mainly include water injections, tablets, and ointments. There are no capsules, and water injections need to be injected, which is inconvenient to use. Ointments can only be used for local treatment and cannot be administered systemically. Tablets can be taken orally, which is more convenient. However, the disintegration rate and bioavailability of tablets are much lower than those of capsules, and the stability of enteric-coated tablets is not as good as that of enteric-coated capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, prepare 1000 calf blood deproteinized capsules

[0020] Capsule content is made up of following raw material: calf blood deproteinized extract (mass percentage of solid content is 4%) 2500g, potato starch 149.75g, p-hydroxybenzoic acid ethyl ester (paraben ethyl ester) 0.25g .

[0021] 1. Preparation of deproteinized calf blood extract

[0022] 2500g calf blood deproteinized extract (mass percentage of solids is 4%) is prepared according to the method described in the patent No. ZL96120777.9 and the title of invention is "a method for extracting calf blood deproteinized extract" :

[0023] Collect the venous blood of Northeast purebred yellow cattle aged 1-6 months under sterile conditions, centrifuge at 4000rpm, 4°C for 15 minutes under sterile conditions to separate the serum, take 12L of serum, add 24L of 96% ethanol, keep stirring, statically Set aside for 60 minutes to denature and precipitate the protein, then centrifuge at 20,000rpm at 4°C for 30...

Embodiment 2

[0028] Embodiment 2, production of 1000 calf blood deproteinized capsules

[0029] The contents of the capsule consist of the following raw materials: calf blood deproteinized extract (solid content: 4% by mass) 3125g, pregelatinized starch 122.5g, dimethyl fumarate 2.5g.

[0030] 1. Preparation of deproteinized calf blood extract

[0031] According to the method described in the patent No. ZL 96120777.9, the title of the invention is "A method for extracting protein-free extract from calf blood":

[0032] Collect the venous blood of Northeast purebred yellow cattle aged 1-6 months under sterile conditions, centrifuge at 4000rpm, 4°C for 15 minutes under sterile conditions to separate the serum, take 15L serum, add 30L 96% ethanol, stir constantly, Set aside for 60 minutes to denature and precipitate the protein, then centrifuge at 20,000rpm at 4°C for 30min, discard the precipitate to obtain 37.5L of supernatant, use a vacuum rotary evaporator to remove ethanol under reduced...

Embodiment 3

[0037] Embodiment 3, animal experiments

[0038] Experimental Materials

[0039]Calf blood deproteinized injection (recipe: each tube contains 5ml of calf blood deproteinized extract with a solid content of 4%, produced by Jinzhou Aohong Pharmaceutical Co., Ltd.).

[0040] Preparation of protein-free calf blood capsules: the contents of protein-free calf blood capsules are the same as in Example 1.

[0041] Preparation of starch enteric-coated capsules: After the potato starch is dried, it is packaged with enteric-coated microcapsules for animals.

[0042] 1. Effect of Calf Blood Quprotein Capsules on Normal Pressure Oxygen Tolerance of Mice

[0043] Choose 100 healthy Kunming first-class mice, body weight 18-22g (provided by the Experimental Animal Center of Jinzhou Medical College), half male and half male, equally divided into five groups, namely three experimental groups of calf blood deproteinized capsules (I, II, III group), calf blood deproteinized injection experime...

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PUM

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Abstract

A deproteinized calf blood capsule for treating the nerve function deficiency, artery vessel diseases, leg ulcer, burn, scald, erosion, wound, etc is composed of an enteric shell and a medicine prepared from the extract of deproteinized calf blood, starch and bacterial depressant. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a new dosage form of protein-free calf blood extract and a preparation method thereof, in particular to protein-free calf blood capsules and a preparation method thereof. Background technique [0002] Calf blood deproteinized products can promote the uptake and utilization of glucose and oxygen by cells. In the case of low blood oxygen and increased energy demand, this product can promote energy metabolism and increase oxygen supply. It can treat neurological deficits caused by brain blood circulation and nutritional disorders (ischemic damage, craniocerebral trauma); it can treat peripheral arterial and venous circulation disorders and the arterial vascular diseases and leg ulcers caused by them; It can treat skin burns, scalds, erosions, skin and mucous membrane damage caused by radiation; heal wounds (trauma, bedsores). [0003] At present, calf blood deproteinized products mainly include water injections, tablets, and oin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/14A61K9/48A61P17/02A61P25/00A61K35/16
Inventor 王洪新于洪儒
Owner JINZHOU AHON PHARM CO LTD
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