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Bone strengthening dripping pills with Premena fulva craib as raw material and method for preparing the same

A technology for strengthening bones and dropping pills is applied in the fields of medical raw materials derived from angiosperm subphylum, pill delivery, bone diseases, etc. It can solve the bioavailability of the first-pass effect of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment, and is not conducive to the overall health of the society. level and other issues to achieve the effect of improving bioavailability, high bioavailability and drug safety

Inactive Publication Date: 2008-03-19
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the quality of the drug. Efficacy also directly affects the therapeutic effect
At the same time, conventional oral dosage forms often produce relatively large dust pollution during the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
The production process of conventional oral preparations is also relatively complicated, and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Now with several groups of specific examples, the preparation method of the Jiangu Dropping Pills of the present invention will be further described.

[0031] [Group 1; Single-Matrix Trials]

[0032] 1. Preparation of the drug extract: According to [Preparation Method 1], the dry powder of the extract containing the active ingredients of traditional Chinese medicine and bone is prepared in advance for later use;

[0033] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0034] 3. Proportion: take g or kg as the unit, drug extract: matrix = 1:1~1:9;

[0035] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Jiangu Dropping Pills of different specifications.

[0036] [test results]

[0037] Test 1: In order to ob...

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PUM

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Abstract

The invention provides a kind of bone-tonifying drop pill having the functions of activating blood circulation and removing stasis, strengthening the muscles and bones, dispelling wind and relieving pain and for the treatment of vertebra hyperosteogeny and rheumatic arthritis. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate administration dosage, low price, no acute allergic reaction or adverse effect, and facilitated transportation and carrying. The drop pill is prepared from Premna fulva Craib. as raw material, and medicinal carrying agent as the base material.

Description

technical field [0001] The invention relates to a pharmaceutical composition which has the effects of promoting blood circulation and dispelling blood stasis, strengthening tendons and bones, expelling wind and relieving pain, and is used for the treatment of vertebral hyperostosis, rheumatic arthralgia and other diseases. A pharmaceutical composition oral preparation. Background technique [0002] According to the ministerial drug standard WS 3 -B-2768-97 prepared by the preparation method given in the Jiangu injection is a blood circulation, blood stasis, strong tendons and bones, dispelling wind and analgesic effect, used for spinal hyperplasia, rheumatic joint pain The pure traditional Chinese medicine injection for the treatment of such diseases has been clinically verified and has definite curative effect. It is a commonly used drug for clinical and family treatment of such diseases. [0003] The following is the drug standard WS 3 -Recipe and process and brief desc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/18A61K135/00A61P19/10A61P19/02A61P29/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司