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Medicinal composition for treating diabetes and its preparation method

A technology of composition and medicine, which is applied in the field of medicine, can solve problems such as excessive gas, aggravating blood sugar instability in diabetic patients, and affecting the hypoglycemic effect of acarbose, and achieves the effects of good formability, stable curative effect, and elimination of constipation

Inactive Publication Date: 2008-05-28
刘展欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are two types of acarbose preparations on the market: ordinary tablets and capsules. Clinical trials have shown that acarbose can significantly reduce the blood sugar level of postprandial patients, but the most common adverse reactions are gastrointestinal reactions. Mainly it can cause intestinal gas, abdominal distension, abdominal pain, etc. Many patients discontinue treatment due to gastrointestinal reactions
In addition, constipation is also a non-negligible reason for the aggravation of blood sugar instability in diabetic patients. Constipation makes the carbohydrates, disaccharides and polysaccharides in food ingested by patients stay longer in the human body and convert into more sugar, which greatly affects blood sugar. Hypoglycemic effect of acarbose

Method used

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  • Medicinal composition for treating diabetes and its preparation method
  • Medicinal composition for treating diabetes and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: A kind of acarbose composition tablet

[0042] Acarbose 50.0g

[0043] Simethicone 50.0g

[0044] Basic magnesium carbonate 80.0g

[0045] Starch 200.0g

[0046] Sodium carboxymethyl starch 8.0g

[0047] Talc powder 4.0g

[0048] Magnesium Stearate 4.0g

[0049] Polyvinylpyrrolidone 2.0

[0050] water 50ml

[0051] Its preparation method is as follows:

[0052] Add simethicone to basic magnesium carbonate, mix evenly, add acarbose and starch, mix evenly, add polyvinylpyrrolidone and water mixed solution to make soft material, granulate, dry, granulate, add carboxymethyl Sodium starch glycolate, talcum powder, and magnesium stearate, mixed evenly, and pressed into tablets to obtain 1000 tablets. Generally calculated according to the content of acarbose, 50-200 mg / time, 3 times / day, before meals.

Embodiment 2

[0053] Embodiment 2: A kind of acarbose composition tablet

[0054] Acarbose 120.0g

[0055] Simethicone 80.0g

[0056] Micronized silica gel 80.0g

[0057] Dextrin 150.0g

[0058] Sodium Carboxymethyl Cellulose 15.0g

[0059] Magnesium Stearate 3.0g

[0060] Gelatin 4.0g

[0061] water 50ml

[0062] Its preparation method is as follows:

[0063] Add simethicone to micropowder silica gel, mix evenly, add acarbose and dextrin, mix evenly, add a mixture of gelatin and water to make a soft material, granulate, dry, granulate, add carboxymethyl cellulose Sodium and magnesium stearate, mixed evenly, and pressed into tablets to obtain 1000 tablets. Generally calculated according to the content of acarbose, 50-200 mg / time, 3 times / day, before meals.

Embodiment 3

[0064] Embodiment 3: A kind of acarbose composition capsule for treating diabetes

[0065] Acarbose 70.0g

[0066] Simethicone 30.0g

[0067] Micronized silica gel 50.0g

[0068] Starch 180.0g

[0069] Sodium carboxymethyl starch 15.0g

[0070] Talc powder 4.0g

[0071] Polyvinylpyrrolidone 3.0g

[0072] water 50ml

[0073] Its preparation method is as follows:

[0074] Add simethicone to micropowder silica gel, mix evenly, add acarbose, starch, carboxymethyl starch sodium and mix evenly, add polyvinylpyrrolidone and water mixture to make soft material, granulate, dry, granulate, Add talcum powder, mix well, and fill capsules to obtain 1000 capsules. Generally calculated according to the content of acarbose, 50-200 mg / time, 3 times / day, before meals.

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Abstract

A composite medicine for treating diabetes contains acarbase, dimethyl silicon oil, absorbent and medicinal auxiliary. Its preparing process is also disclosed.

Description

field of invention [0001] The invention relates to the technical field of medicine, in particular the invention relates to a pharmaceutical composition for treating diabetes and a preparation method thereof. Background of the invention [0002] The number of diabetics in my country has reached 23.8 million, which is the country with the largest number of diabetic patients. Diabetic patients place a heavy burden on society. [0003] Diabetes has great harm to human health, and this harm often occurs unconsciously. If a patient does not pay attention at ordinary times, once the acute complications of diabetes occur, sometimes it can endanger the life of the patient. The chronic complications of diabetes are changes caused by long-term poor control of blood sugar, including large blood vessels, microvascular and neuropathy, which can greatly reduce people's health and work ability, and even cause disability or premature death. [0004] At present, the drugs for treating diabe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61K9/16A61K9/20A61K9/48A61P3/10
Inventor 刘展欣
Owner 刘展欣
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