Interleukin-17 acceptor, and its coding gene and application

A technology of interleukins and receptors, applied in the fields of proteins and their coding genes and applications, to achieve great practical significance and broad application prospects
CN100417664CInactive Publication Date: 2008-09-10TSINGHUA UNIV
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2008-09-10
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

This invention discloses an acceptor of inferleukin 17 and its code and their application, the objective is to provide an acceptor of inferleukin 17 and its code gene and their application of preparing mark substance for diagnose tumour and treatment medicine for RAS / MAPK signal access related diseases. The albumen is a protein with following one of the sequence of amino-acid residue radical: 1) SEQ ID No: 2 in sequence table; 2) amino-acid residue radical sequence in SEQ ID No: 2 in the sequence table are replaced by one to ten of amino-acid residue radical, lose or added and through activating RAS / MAPK signal access and with promoting karyokinesis action protein. inferleukin 17 acceptorof this invention will play a important roll in diagnose tumor, since its code gene mIL-17RE interferes the code gene of RNA, it can be used as active component to prepare medicine, for treatment diseases related to RAS / MAPK signal access, such as prostate tumour, leukaemia and thyroid gland tumour and other diseases. The invention has more practical meaning and wide application prospect in medical science and biological pharmacy field.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to proteins and their coding genes and applications, in particular to a mouse-derived interleukin 17 receptor and its coding genes and their use in the preparation of tumor diagnostic markers and therapeutic drugs for diseases related to RAS / MAPK signaling pathways Applications. Background technique

[0002] The interleukin 17 (IL-17) and its receptor (IL-17R) family is a unique immune molecule-receptor family that plays an important role in normal body immunity, inflammatory response and tumorigenesis (J.K.Kolls, A . Linden, Interleukin-17 family members and inflammation. Immunity 21(4) (2004) 467; T.A. Moseley, D.R. Haudenschild, L. Rose, A.H. Reddi, Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 14(2 ) (2003) 155). Currently known IL-17 ligands have six members, and each ligand acts on a different immune process. For example, the earliest discovered IL-17A can stimulate a variety of tissue cell...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More