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Medicine composition for treating women's pulvic infection, prepn process and use thereof

A composition and drug technology, applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of gynecological pelvic inflammatory disease without rhubarb peony soup, no industrialized production products, and inability to reach the lesion quickly, so as to prolong the life of the drug. Effect of duration of action, enhanced bioavailability, prolonged residence and release time

Active Publication Date: 2009-04-08
ZHONGJING WANXI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Edited by Duan Fujin. Prescriptions. Shanghai Science and Technology Press, 1998, 42-43). At present, there have been reports of using modified Dahuang Mudanpi Decoction to treat pelvic inflammatory disease. For example: Zhang Liang, Lin Ruping, Dahuang Mudan Decoction in the treatment of chronic 42 cases of pelvic inflammatory disease, Anhui Clinical Journal of Traditional Chinese Medicine, Volume 10, Issue 1, February 1998; Zhu Yanchun, Dahuang Peony Decoction in the treatment of acute pelvic inflammatory disease, article number: 1004-745X(2001)04-0189-01, reported Dahuang Peony Addition and subtraction of the soup: 10g each of rhubarb, peony bark, peach kernel, and red peony root, 30g of red rattan, 20g of Renaceae, Patrinia, wine Corydalis, 15g each of Chuan Toosendan and Salvia miltiorrhiza, 5g of raw licorice. It is prescribed by clinicians, and can be added or subtracted according to clinical symptoms; other reports are mostly rhubarb and peony decoction combined with other methods to treat pelvic inflammatory disease, and it is prescribed by clinicians, and there is no related report of industrialized production products; Japan has rhubarb The granules and pills of Mudanpi Decoction are very inconvenient for patients to use. Because the rhubarb in the original decoction needs to be used "afterwards", the quality of the preparation is not easy to control. Disadvantages of relatively slow speed of action and low bioavailability
At present, there is no report on external application of Dahuang Mudan Decoction to treat gynecological pelvic inflammatory disease

Method used

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  • Medicine composition for treating women's pulvic infection, prepn process and use thereof
  • Medicine composition for treating women's pulvic infection, prepn process and use thereof
  • Medicine composition for treating women's pulvic infection, prepn process and use thereof

Examples

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Effect test

Embodiment 1

[0028]Embodiment 1 The preparation of medicinal material clear ointment of the present invention

[0029] 1. Rhubarb and peony cortex are refluxed twice with 5-10 times the amount of 60-95% ethanol, each time for 0.1-1.5 hours. Combine the extracts, recover ethanol until it has no alcohol smell; or percolate with 5-15 times of 85-95% ethanol, recover the ethanol until it has no alcohol smell, and obtain the extract ①;

[0030] 2. Put peach kernels, wax gourd kernels (winter melon seeds), salvia miltiorrhiza, and Patrinia in boiling water 6-10 times, extract twice, decoct for 0.5-1.5 hours each time, filter the extract, and concentrate the filtrate under reduced pressure , get extract ②;

[0031] 3. Combine extract ① and extract ②, stir evenly, and condense into a clear paste with a density of 1.10-1.40.

Embodiment 2

[0032] Example 2 Preparation of Tablets for External Use

[0033] 1. Common excipients for tablets are starch, soluble starch, lactose, magnesium stearate, dextrin, mannitol, sodium carboxymethyl starch, talcum powder, etc.

[0034] 2. Take clear ointment, add appropriate amount of commonly used excipients for tablets, granulate, dry, and compress into tablets.

[0035] By selecting different auxiliary materials, it can be made into vaginal tablets specified in the 2000 edition of "Chinese Pharmacopoeia", which can be ordinary tablets or effervescent tablets.

Embodiment 3

[0036] Example 3 Preparation of Effervescent Tablets for External Use

[0037] 1. Selection of excipients: common excipients for ordinary tablets, one or more of sodium bicarbonate, tartaric acid, citric acid, and fumaric acid.

[0038] 2. Preparation method:

[0039] (1) Take an appropriate amount of clear paste, add lactose and soluble starch, granulate, dry, and obtain ①;

[0040] (2) Sodium bicarbonate is dissolved in an appropriate amount of ethanol, and sprayed in a container containing ① through a sprayer to obtain ②;

[0041] (3) Tartaric acid and fumaric acid are granulated, dried, mixed evenly with ②, and pressed into tablets to obtain the product.

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Abstract

The medicine composition for treating women's pulvic infection is prepared with Chinese medicinal materials rhubarb, tree peony bark, peach kernel and wax gourd seed kernel. The medicine composition may be used in treating acute and chronic women's pulvic infection via oral taking or external application. When applied externally in vagina or rectum, the medicine can reach the affected part directly for fast absorption and high bioavailability while avoid liver's first pass effect. The medicine composition of the present invention is stable and controllable.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gynecological pelvic inflammatory disease. Specifically, it is a pharmaceutical composition for treating gynecological pelvic inflammatory disease prepared from traditional Chinese medicines, and belongs to the field of traditional Chinese medicines. Background technique [0002] Pelvic inflammatory disease is a general term for inflammation caused by bacterial invasion of female reproductive organs and their surrounding connective tissue and pelvic membrane. Depending on the location of the disease, there are uterine corpitis, adnexitis (salpinx, oophoritis), pelvic connective tissue inflammation, and pelvic peritonitis. According to the course of the disease, it can be divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease. Pelvic inflammatory disease is a common disease in gynecology, especially chronic pelvic inflammatory disease is more common. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61K36/71A61K36/708A61K36/53A61K36/42A61K36/185A61K9/16A61K9/20A61K9/48A61K9/08A61K9/10A61P15/00A61K9/00A61K9/02
Inventor 阳向波谢永平李慧琴张媛
Owner ZHONGJING WANXI PHARMA CO LTD
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