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Gynecopathy treating formulation and preparation process thereof

A technology for pharmaceutical preparations and gynecological diseases, which is applied in the field of pharmaceutical preparations for the treatment of gynecological diseases and its preparation. It can solve the problems of large doses of granules, low bioavailability, and backward dosage forms, and achieve improved bioavailability and bioavailability. High, increased stability effect

Active Publication Date: 2009-06-10
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Gynecological diseases such as pelvic inflammatory disease, endometritis, and cervicitis are common diseases that threaten women's physical and mental health in the world today, and have brought great pain to women. The traditional treatment methods are mostly antibiotics or physiotherapy. Long-term use Antibiotics can make patients develop drug resistance and easily cause double infection, and physical therapy makes most patients unable to persist for a long time and interrupt treatment
In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research, and also provided some therapeutic products; such as: Jinji Capsule, Jinji Tablets, and Jinji Granules are all developed to treat such diseases, but, The technical prescriptions of these three products are not disclosed, so they cannot be directly used for production guidance; moreover, the dosage form of the existing Jinji pharmaceutical preparations is backward, and the product quality is not ideal: the disintegration performance of the tablets is poor, and the capsules become sticky after long-term storage. As a result, the dosage of granules is large, and the taste of Andrographis paniculata is extremely bitter, so a large amount of flavoring agents with no therapeutic effect need to be added; the dosage forms of existing products are not rich enough, the range of applicable people is narrow, the product bioavailability is low, and the drug stability is not stable. Ideal, especially the bioavailability of its water-insoluble active ingredient andrographolide is not high, the taste is extremely poor, which is not conducive to the absorption and utilization of the human body; in view of these situations, it is necessary to look for an effective therapeutic drug preparation with ideal therapeutic effect and stable and controllable quality has become something that people urgently need to solve

Method used

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  • Gynecopathy treating formulation and preparation process thereof
  • Gynecopathy treating formulation and preparation process thereof
  • Gynecopathy treating formulation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] Experimental Example 1: Research on Extraction Process

[0020] 1. Selection of decoction and extraction conditions of medicinal materials

[0021] (1) Factor selection The decoction and extraction effect of traditional Chinese medicine is affected by factors such as the amount of water added, extraction time, and extraction times. The applicant selects the amount of water added as a factor, and focuses on the influence of different levels of factors on the decoction extraction effect. Combined with production cost, energy and other aspects to comprehensively consider, select the factor level.

[0022] (2) Index Determination Select two items of extract yield and berberine hydrochloride content as evaluation index, its reason and measuring method are as follows:

[0023] ① Yield rate of extract: extract is the material basis for solid preparations to exert their curative effect, and its yield directly affects the preparation process, so choosing it as an extraction in...

experiment example 2

[0036] Experimental Example 2: Study on Separation, Concentration and Drying Process

[0037] Separation process research: In order to facilitate production operation control, the extract was filtered with a 200-mesh filter cloth, and the extract was combined.

[0038] Concentration process research: use three-effect concentration tanks for concentration, and the extract is concentrated to a thick paste with a relative density of 1.30 (60°C). The degree is -0.025Mpa for the first effect, -0.045Mpa for the second effect, and -0.065Mpa for the third effect.

[0039] Drying process research: vacuum drying conditions: 60 ~ 70 ℃, -0.08Mpa.

[0040] The results show that the extraction process of the present invention is reasonable and feasible.

experiment example 3

[0041] Experimental Example 3: Research on Molding Process

[0042] Angle of repose measurement: Use the fixed funnel method, fix the funnel on the coordinate paper placed horizontally, the distance between the lower opening of the funnel and the coordinate paper is 3cm, pour different prescription pills into the funnel, until the tip of the cone formed at the bottom touches Measure the diameter of the bottom of the cone to the mouth of the funnel below, and calculate the angle of repose. A small angle of repose indicates good fluidity of the particles.

[0043] Disintegration time limit inspection: use the rotating basket method, lifting disintegration instrument, take 6 tablets / capsules of tablets or capsules, and observe the situation of passing through the sieve. The higher the pass rate, the better the disintegration, which is more suitable for human body absorption.

[0044] Solubility test: Take 10g of granules, heat water 20 times, stir for 5 minutes, and observe imme...

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Abstract

Disclosed is a gynecopathy treating formulation containing leatherleaf milletia and preparation process, which is prepared mainly from Rosa Laevigata Michx root, spatholobus stem, Moghania philippinensis and mahonia stem. The preparation can be made into the dosage forms of dispersible tablet, soft capsules, mini-pills or dripping pills.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation for treating gynecological diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. technical background: [0002] Gynecological diseases such as pelvic inflammatory disease, endometritis, and cervicitis are common diseases that threaten women's physical and mental health in the world today, and have brought great pain to women. The traditional treatment methods are mostly antibiotics or physiotherapy. Long-term use Antibiotics can make patients develop drug resistance and easily cause double infection, and physical therapy makes most patients unable to persist for a long time and interrupt treatment. In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research, and also provided some therapeutic products; such as: Jinji Capsule, Jinji Tablets, and Jinji Granules are all devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P15/00
Inventor 于文风
Owner GUIZHOU JINGFENG INJECTION
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