Process for preparing notoginseng triol saponin and use thereof

A technology of triol saponin and alcohol saponin, which is applied in the preparation field of extracting notoginseng triol saponin from Panax notoginseng, to achieve the effect of convenient taking, fast absorption and increasing arterial blood flow

Active Publication Date: 2009-06-17
李明劲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] After many years of research, the inventors have found that many ingredients in Panax notoginseng saponins are ineffective in resisting platelet aggregation and preventing thrombosis, and that the truly effective ones are notoginseng triol saponins, etc. Requirements, properties, relevant pharmacological effects and effects on the human body involved in this patent have not been reported

Method used

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  • Process for preparing notoginseng triol saponin and use thereof
  • Process for preparing notoginseng triol saponin and use thereof
  • Process for preparing notoginseng triol saponin and use thereof

Examples

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Effect test

example 1

[0038] Example 1: Chemical composition of panaxtriol saponin (PTS)

[0039] ①, Notoginsenoside C 1 、D 1 separation

[0040] Thin-layer silica gel (10-40 μ produced by Qingdao Ocean Chemical Factory) dry packing ( 42*400mm). PTS is dissolved in dilute alcohol, mixed with a thin layer of silica gel, dried at low temperature, loaded on the top of the column, and the lower phase of chloroform-methanol-water (65:35:10) is the developing solvent, received by the automatic sampling receiver, each 20 ml . Thin-layer chromatography identification, spotting on high-efficiency thin-layer silica gel plate (produced by Qingdao Ocean Chemical Factory), and developing on the horizontal development tank, the developing solvent is the same as the developing agent system of column chromatography, drying in the air after development, spraying with sulfuric acid ethanol solution, 105 Bake at ℃ for 5 minutes, or bake with hot air with an electric hair dryer, take the fractions with the same ...

example 2

[0101] Example 2: Prepare notoginseng triol saponin according to the following steps:

[0102] A. Take notoginseng and crush it through No. 1 sieve, add 60% ethanol to soak for 14 hours, then evenly compact and fill it into the percolation barrel;

[0103] B. Percolation of 60% ethanol with 6 times the amount of medicinal materials until the effluent has no saponin reaction, and the flow rate is 3 ml / min per kilogram of medicinal materials. Control the upper and lower flow rates to be equal, and the column cannot be dried;

[0104] C. When the vacuum degree is 0.04Mpa and the temperature is 50-55°C, the percolation liquid is concentrated under reduced pressure, and ethanol is recovered. The concentrated liquid has no alcohol smell, and the relative density is 1.06-1.12;

[0105] D. Add water to 3 times the amount of the percolation liquid after being concentrated to no alcohol smell, centrifuge, take the clear liquid and put it on the column, the dropping speed is 3 ml / min pe...

example 3

[0108] Example 3: Prepare notoginseng triol saponin according to the following steps:

[0109] A. Take notoginseng and crush it through No. 1 sieve, add 90% ethanol to soak for 28 hours, then evenly compact and fill it into the percolation bucket;

[0110] B. Percolation of 60% ethanol with 12 times the amount of medicinal materials until the effluent has no saponin reaction, the flow rate is 7 ml / min per kilogram of medicinal materials, the soaking liquid flows out to the full liquid level when percolating, and then 60% ethanol is added dropwise, Control the upper and lower flow rates to be equal, and the column cannot be dried;

[0111]C. When the vacuum degree is 0.08Mpa and the temperature is 50-55°C, the percolation liquid is concentrated under reduced pressure, and ethanol is recovered. The concentrated liquid has no alcohol smell, and the relative density is 1.06-1.12;

[0112] D. Add water to 6 times the amount of the percolation liquid after being concentrated to no ...

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Abstract

The invention discloses a process for preparing notoginseng triol saponin and use thereof, which includes following steps: crushing the notoginseng, and adding ethanol solution whose concentration is 50 to 90% to immerse and percoalte the notoginseng, and then collecting the percoalted liquid and reducing pressure to concentrate the same, and then using distilled water to dilute the concentrated liquid, and then slowly filling the liquid into the large-hole absorption resin separating column, and using 40% ethanol to elute, and then collecting the 40% ethanol elutriant and refining the same to obtain notoginseng triol saponin. The notoginseng triol saponin extracted by the provided process contains all triol saponin in the notoginseng, wherein contains 156 to 79 % ginsenosiderx Rg, 5.0 to 7.5 % of ginsenosiderx Re, 11 to 14 % triol saponin R1, 78 to 98 % of notoginseng triol saponin. The notoginseng triol saponin can be used in treatment for cardiocerebrovascular embolic disease, and has advantages including high content, stable quality, good colour, low cost, and its organic solvent residual amount complies with drug standard.

Description

field of invention [0001] The present invention relates to a method for extracting medicinal plants and its application, more particularly to a preparation method for extracting notoginseng triol saponins from Panax notoginseng and its application. Background technique [0002] Panax notoginseng is a traditional Chinese medicine commonly used in traditional Chinese medicine. Its functions are recorded in the Chinese Pharmacopoeia as dispelling blood stasis, stopping bleeding, reducing swelling and relieving pain. [0003] Notoginseng triol saponin is the saponin extract of the single traditional Chinese medicine Panax notoginseng (also known as Tianqi, ginseng notoginseng), which is the effective part of Sanqi to promote blood circulation and remove blood stasis. Saponins Rg1, Re, and notoginseng saponin R1, and a small amount of Rb1, Rd, etc. [0004] Panax notoginseng, also known as Tianqi or Panax notoginseng, is the rhizome of Panax notoginseng (Burk) F.H.Chen of Aralia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K31/704A61P9/10A61P7/02
Inventor 李明劲
Owner 李明劲
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