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Radiant stand, radiant polyurethane coating material and their production

A polyurethane coating and radioactive technology, which is applied in the field of preparation of radioactive stents, can solve problems such as restenosis of esophagus and other lumens, and achieve the effects of easy activity, easy protection, and simple manufacture

Inactive Publication Date: 2009-06-24
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The strength of the stent surface membrane material (especially the stent radioactive coating) is not very high. Advanced tumors, such as patients with esophageal cancer, grow rapidly and easily penetrate the stent membrane or coating into the interior of the stent, causing esophagus and other lumens. restenosis;

Method used

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  • Radiant stand, radiant polyurethane coating material and their production

Examples

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Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Preparation of radioactive coating material

[0024] Polyurethane was dissolved in tetrahydrofuran to prepare an 8% (w / w) solution. Take medical use 32 P—sodium phosphate oral liquid, add 3 times (molar ratio) of non-radioactive Na 2 HPO 4 Solution and carbon nanotube solution, the admixture of carbon nanotube is 0.4% of polyurethane quality, adjust pH to be 9, then use CrCl 3 solution to precipitate it, CrCl 3 The number of moles of the solution is Na 2 HPO 4 2 times the solution. Centrifuge and wash with tetrahydrofuran for 4 times, and finally add these radioactive precipitates to the prepared polyurethane solution, and stir evenly to obtain the radioactive coating material.

Embodiment 2

[0025] Embodiment 2 Preparation of radioactive coating material

[0026] Polyurethane was dissolved in tetrahydrofuran to prepare a 6% (w / w) solution. Take medical use 32 P—sodium phosphate oral liquid, add 3 times (molar ratio) of non-radioactive Na 2 HPO 4 Solution and carbon nanotube solution, the doping amount of carbon nanotube is 0.2% of polyurethane quality, adjust pH to be 8, then use CrCl 3 solution to precipitate it, CrCl 3 The number of moles of the solution is Na 2 HPO 4 2 times the solution. Centrifuge and wash with tetrahydrofuran for 3 times, and finally add these radioactive precipitates to the prepared polyurethane solution, and stir evenly to obtain the radioactive coating material.

Embodiment 3

[0027] Example 3 Preparation of radioactive coating material

[0028] Polyurethane was dissolved in N,N-dimethylformamide to prepare a 5% (w / w) solution. Take medical use 32 P—sodium phosphate oral liquid, add 2 times (molar ratio) of non-radioactive Na 2 HPO 4 Solution and carbon nanotube solution, the doping amount of carbon nanotube is 0.6% of polyurethane quality, adjusts pH to be 12, then with CaCl 2 solution to precipitate it, CaCl 2 The number of moles of the solution is Na 2 HPO 4 3 times the solution. Centrifuge and wash with tetrahydrofuran for 5 times, and finally add these radioactive precipitates to the prepared polyurethane solution, and stir evenly to obtain the radioactive coating material.

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Abstract

A radioactive polyurethane coating material for the radioactive scaffold of esophagus to treat esophagus cancer contains proportionally radioactive nuclein and carbon nanotubes for improving strength and preventing the leakage of radioactive substance. Its preparing process, said radioactive scaffold and the preparing process of said radioactive scaffold are also disclosed.

Description

technical field [0001] The invention relates to the preparation of radioactive stents, in particular to a radioactive polyurethane coating material, the prepared radioactive stents, and their preparation methods. Background technique [0002] Because radioactive stents not only have mechanical support, but also can treat and prevent restenosis by killing cells through radiation, they are now widely used in local tissues of organisms caused by various reasons, especially the narrowing of lumens, such as Obstruction and stenosis of various lumens such as the digestive tract, urogenital tract, respiratory tract, and blood vessels caused by tumors, scars, and other objects; or vascular obstruction and stenosis caused by factors such as inflammation, tumors, thrombus, and atheromatous plaques. The most common of these are the treatment of tumors of the esophagus, biliary tract, trachea, ureter, and blocked or narrowed coronary arteries. [0003] For radioactive stents and their ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61F2/82A61N5/10
Inventor 吴胜伟李文新董生李燕
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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