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Dispersion tablet for improving brain circulation

A technology of dispersible tablets and dihydroergot alkaloid methanesulfonate, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, drug combinations, etc.

Active Publication Date: 2010-01-13
海南金瑞宝医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dihydroergot alkaloid mesylate is white or off-white crystalline powder, which is slightly soluble in aqueous solution. According to the common knowledge known to those skilled in the art, the dissolution rate of this drug with certain solubility in aqueous solution should be easy Solved, however, for dihydroergot alkaloid mesylate, it seems to be contrary to the above theory, and it has been proved that for ordinary dihydroergot alkaloid mesylate tablet, the dissolution rate in vitro is only about 87% in 30 minutes

Method used

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  • Dispersion tablet for improving brain circulation
  • Dispersion tablet for improving brain circulation
  • Dispersion tablet for improving brain circulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] prescription:

[0050]

[0051] Preparation Process:

[0052] Accurately weigh the raw material of dihydroergot alkaloid methanesulfonate, add it into water, stir until completely dissolved, and set aside.

[0053] Mix the microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose and 2 / 3 of the prescription amount of sodium carboxymethyl starch evenly, pass through an 80-mesh sieve, and set aside.

[0054] Sprinkle the above-mentioned spare solution evenly on the above-mentioned auxiliary materials, stir evenly, then add appropriate amount of water as a binder, and prepare a soft material after stirring evenly, add the remaining 1 / 3 sodium carboxymethyl starch, magnesium stearate and micropowder after drying The silica gel is granulated, mixed evenly, after measuring the intermediate to determine the weight of the tablet, pressing the tablet, and packaging it after passing the full inspection.

Embodiment 2

[0056] prescription:

[0057]

[0058] Preparation Process:

[0059] Accurately weigh the raw material of dihydroergot alkaloid methanesulfonate, add it into 30% ethanol aqueous solution, and stir until completely dissolved.

[0060] Mix the microcrystalline cellulose, lactose, pregelatinized starch, cross-linked polyvinylpyrrolidone and 3 / 4 sodium carboxymethyl starch evenly, pass through a 100-mesh sieve, and set aside.

[0061] Sprinkle the above-mentioned spare solution evenly on the above-mentioned auxiliary materials, stir evenly, then add an appropriate amount of aqueous solution of hydroxypropyl methylcellulose as a binder, stir well and prepare a soft material, add the remaining 1 / 4 carboxymethyl starch after drying Sodium, magnesium stearate and micropowder silica gel are granulated, mixed evenly, after measuring the intermediates to determine the weight of the tablet, compressed into tablets, and packed after passing the full inspection.

Embodiment 3

[0063] prescription:

[0064]

[0065] Preparation Process:

[0066] Accurately weigh the raw material of dihydroergot alkaloid methanesulfonate, add it into 10% ethanol aqueous solution, stir until completely dissolved, and set aside.

[0067] First mix the mannitol, pregelatinized starch, croscarmellose sodium and 4 / 5 sodium carboxymethyl starch evenly, pass through a 120-mesh sieve, and set aside.

[0068] Sprinkle the above-mentioned spare solution evenly on the above-mentioned auxiliary materials, stir evenly, then add an appropriate amount of aqueous solution as a binder, and prepare a soft material after stirring evenly, add the remaining 1 / 5 sodium carboxymethyl starch, micro-powdered silica gel for granulation after drying, and mix Evenly, measure the intermediates to determine the weight of the tablet, press the tablet, and pack it after passing the full inspection.

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PUM

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Abstract

The invention provides dihydroergotoxine mesylate dispersible tablet and its preparation method. The dispersible tablet comprises dihydroergotoxine mesylate 1 part, disintegrating agent 5-200 parts, and diluent 20-800 parts. The preparation method comprises dissolving dihydroergotoxine mesylate in some solvent, adding adjuvant, stirring, adding proper amount of solvent or binding agent, preparing soft material, granulating, and tabletting. The dispersible tablet has rapid disintegration and dissolving.

Description

technical field [0001] The invention provides a dihydroergot alkaloid mesylate dispersible tablet, especially the dihydroergot alkaloid mesylate dispersible tablet containing a disintegrating agent and a diluent which have been screened. Background technique [0002] Dihydroergot alkaloid mesylate is a drug that promotes cerebral blood circulation, which can reduce cerebrovascular resistance, increase blood flow, or improve blood viscosity, improve damaged brain metabolism, and shorten cerebral circulation time; the drug also It can directly act on DA and 5-HT receptors, reduce cerebrovascular resistance, increase cerebral blood flow and the availability of oxygen to the brain. Therefore, dihydroergot alkaloid mesylate is unique in improving the mental deterioration associated with aging, the function of acute and chronic cerebrovascular diseases, the symptoms and signs of mental decline, and mild to moderate vascular dementia and vascular headache. role. [0003] As a dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/48A61K9/20A61K47/38A61P9/10
Inventor 徐扬杨章贤
Owner 海南金瑞宝医药科技有限公司