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Technology for extracting dihydrogalanthamine from lycoris radiata genus plant

A technology of Amaryllis genus plants and process steps, applied in the direction of drug combination, muscular system diseases, neuromuscular system diseases, etc., can solve problems such as not seen

Inactive Publication Date: 2010-03-31
贵州芊芊园艺新技术发展公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Above-mentioned patent literature and non-patent literature all do not see the record of the production method of the same Ricolamin raw material medicine as the present invention

Method used

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  • Technology for extracting dihydrogalanthamine from lycoris radiata genus plant
  • Technology for extracting dihydrogalanthamine from lycoris radiata genus plant
  • Technology for extracting dihydrogalanthamine from lycoris radiata genus plant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: get 200Kg cleaned fresh amaryllis bulb slices, soak in the multifunctional extraction tank, add 1.3L liquid cellulase (enzyme activity is not less than 2000u / ml), add 800Kg water again, at a temperature of 55 ℃, PH=5, enzymatic hydrolysis for 6 hours. After the enzymolysis is completed, filter and discard the filter residue (the filter residue can be used as fertilizer) to obtain 900Kg of filtrate, and adjust the pH of the enzymolysis solution to 9-10 with 40% aqueous sodium hydroxide solution until the enzymolysis solution becomes turbid. Use the GQ75 high-speed tubular separator to centrifugally separate and remove the slag (the slag is used as fertilizer) to obtain 880Kg of centrifugate, get the centrifugate, and use 2540L ethyl acetate to extract on average in 6 times, and the extraction operation is carried out in the extraction tower for continuous extraction. Organic phase, discarding water phase, waste water phase can be discharged to sedimentation...

Embodiment 2

[0055] Embodiment 2: get the 115g extractum of lycoris through pre-processing gained, after analyzing the content of lycopene is 40%, galantamine 58%, in the aluminum oxide (ratio is 1: 1.2, Granularity 180-200 mesh) grind and mix evenly, add water to be 6% of the weight of alumina, mix well, make the upper column material, take 1725g of basic alumina whose activity level is III grade 7 times the weight and add 6% of the weight of alumina Mix well with water (ratio: 1:7, particle size 180-200 mesh) and put it into a chromatography column (alumina particle size: 180-200 mesh, φ is 8cm, length 82cm), beat and compact it and load it into the upper column material, compact Finally, cover the top with a layer of quartz sand with a thickness of about 0.5cm (or replace it with a piece of filter paper slightly smaller than the diameter of the column) and then use the eluent to elute. Analysis and follow-up detection, collecting the eluent containing Licolamin, evaporated to dryness at...

Embodiment 3

[0056] Embodiment 3: get the 115g extract of lycoris through pre-processing gains, grind and mix with 138g basic alumina of activity level III (ratio is 1: 1.2, particle size 180-200 mesh), add alumina weight 6% Mix well with water to make the upper column material, take 7 times the weight of basic alumina 1725g with activity level III and add 6% water of alumina weight and mix thoroughly, (ratio is 1: 7, particle size 180-200 mesh ) into a chromatographic column (alumina particle size: 180-200 mesh, φ is 8cm, length 82cm), beating and compacting and loading the upper column material, and covering the top with a layer of quartz sand (or Use a piece of filter paper slightly smaller than the diameter of the column instead) and then use the eluent to elute. The eluent formula is ether-methanol-ammonia (100:10:0.5), and the eluent is tracked and detected by thin-layer chromatography. Collect the eluate containing delicolamine and evaporate to dryness at 65°C under reduced pressure...

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Abstract

The invention discloses a process of extracting dihydrogalanthamine from Lycoris radiata plant, which in detail relates to a method for separating dihydrogalanthamine exquisite from alkaloid extractedfrom Lycoris radiata plant, and it is a recombined method of enzyme technology and chromatography. It comprises process and condition of extraction and separation of coarse lycorine, then extractingfiltering liquid of coarse lycorine, condensing, preparing column material, loading column, eluting, condensing, recrystallizing and getting dihydrogalanthamine with purity of over 99%. The inventionis different from method using organic solvent for dihydrogalanthamine extraction, and it can obtain coarse lycorine, coarse galantamin and dihydrogalanthamine with purity over 99%.

Description

Technical field: [0001] The invention relates to a method for extracting effective medicinal ingredients from Lycoris plants. Mainly, it is a method for effectively separating and obtaining Lycolamine from Amaryllidaceae alkaloids extracted from Lycoris plants. Background technique: [0002] Lycoramine, English name: Lycoramine. Alias: Dihydrogalantnamine (Dihydrogalantnamine), lycoramine base. Its structural formula is shown in the figure below: [0003] [0004] Ricolamine has the pharmacological properties of a cholinesterase inhibitor, and it is a reversible acetylcholinesterase inhibitor. It can be used to treat myasthenia gravis, post-poliomyelitis paralysis, hemiplegia caused by cerebrovascular accident, sciatic neuritis and other symptoms. It belongs to nervous system drugs and has very important uses in this field. The structure of ricolamin is similar to that of galantamine, but the strength of action and toxicity of the two are not the same. Its acute toxic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P21/04A61P25/00C07D223/00C07D491/06C12P17/18C07D307/00
Inventor 黄玉君周玉杨航董元红莫莉
Owner 贵州芊芊园艺新技术发展公司
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