15-(14-deoxy 11,12 dehydro) andrographolide carbonic side derivate and preparation process thereof

A technology of ester carbon glycoside derivatives and andrographolide, applied in the field of carbon glycoside compounds and preparation thereof, can solve the problems such as no reports of C15-andrographolide carbon glycoside derivatives, and achieves simple and convenient preparation method, resource Rich, high-yield effects
CN100999535AInactive Publication Date: 2007-07-18ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHENGZHOU UNIV
Publication Date
2007-07-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to carbon glycoside compound, and is especially 15-(14-deoxy-11, 12-dehydro)-andrographolide carbon glycoside derivative and its preparation process. The preparation process includes dewatering andrographolide as precursor compound, epoxidation and other reaction to obtain serial andrographolide derivatives; dissolving the derivatives and beta- carbon glycoside ketone in organic solvent and condensation reaction at certain temperature in the presence of catalyst for certain time. The derivative is significant in developing andrographolide.
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Description

technical field

[0001] The invention relates to a carbon glycoside compound and a preparation method thereof, in particular to a carbon glycoside derivative of andrographolide and a preparation method thereof. Background technique

[0002] Carbon glycosides are a kind of glycoside compounds with a relatively special structure, and their sugar groups are directly connected to aglycones by C-C bonds. The research on glycosides in the past few decades mainly revolves around O-, S- and N-glycosides, while carbon glycosides are relatively less studied due to their analytical complexity. In recent years, with the gradual recognition of the biological activity of carbon glycosides, the research on carbon glycosides has become a research hotspot in the field of glycochemistry and biochemistry.

[0003] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata (Bum.f.) Nees, a plant of the family Acanthaceae. It is one of the main components of Andrograp...

Claims

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