Production and use for kaki-leaf extract

A technology of persimmon leaves and water extracts, applied in the field of pure natural pharmaceutical preparations, can solve undiscovered problems and achieve the effect of promoting modernization

Inactive Publication Date: 2007-09-05
黄仁彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, no report has been found that the active parts of persimmon leaf water extract, alcohol extract, and total flavonoids are made into preparations and used clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1, the extraction of persimmon leaf aqueous extract and the preparation of preparation thereof:

[0058] 1.1 Preparation of water extract of persimmon leaves: Take 10kg of dried coarse powder of persimmon leaves, add 100L of water, boil 3 times, 2 hours each time, filter, collect the boiled liquid, and concentrate it into a thick paste with a specific gravity of 1.3.

[0059] 1.2 Preparation of water extract tablets: Take 10kg of dried coarse powder of persimmon leaves, prepare a thick paste with the same method as item 1.1, weigh and record the weight of the thick paste, add 2 times the amount of edible starch, and add 80% alcohol to mix, and sieve Granulate, dry at 60°C, granulate, add 3% talcum powder, 4% sodium carboxymethyl starch, compress into tablets (0.3g / tablet for plain tablets), sugar-coated tablets (or film-coated tablets), After checking that it complies with the regulations.

[0060] 1.3 Preparation of water extract capsules: Take 10kg of drie...

Embodiment 2

[0064] Embodiment 2, the extraction of persimmon leaf ethanol extract and the preparation of preparation thereof:

[0065] 2.1 Preparation of persimmon leaf ethanol extract: Take 1 kg of dried persimmon leaf powder, add 10 L of 95% ethanol, reflux extraction for 3 times, each time for 2 hours, filter, recover ethanol from the extract, and concentrate it into a thick paste with a specific gravity of 1.3.

[0066] 2.2 Preparation of ethanol extract tablets: take 1 kg of dried persimmon leaf coarse powder, prepare a thick paste with the method in item 2.1, weigh and record the weight of the thick paste, add 2 times the amount of edible starch, and add alcohol with a concentration of 80% to mix evenly. Sieve and granulate, dry at 60°C, granulate, add 3% talcum powder, 4% sodium carboxymethyl starch, compress into tablets (0.2g / tablet for plain tablets), and coat sugar-coated tablets (or film-coated tablets) , after the visual inspection conforms to the regulations.

[0067] 2.3 P...

Embodiment 3

[0071] Embodiment 3, the extraction of persimmon leaf total flavonoids and the preparation of preparation thereof:

[0072] 3.1 Preparation of total flavonoids from persimmon leaves: Weigh 1 kg of persimmon leaf coarse powder, soak in 10 L of 70% ethanol for 30 min, reflux extraction for 2 h, and filter. Add 80L of 70% ethanol to the dregs, reflux for extraction for 1 hour, and filter. The two filtrates were combined and centrifuged (3000γ / min) for 15 min. After recovering ethanol, collect the extract, concentrate under reduced pressure, extract twice with petroleum ether, remove chlorophyll, discard the ether phase, extract the water phase twice with ethyl acetate, combine the ethyl acetate phases, concentrate and dry to obtain the total flavonoids.

[0073] 3.2 Preparation of total flavonoids tablets: take 1 kg of dried coarse powder of persimmon leaves, prepare total flavonoids with the method in item 3.1, weigh and record the weight of total flavonoids, add 2 times the am...

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PUM

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Abstract

An extract of persimmon leaf is prepared from persimmon leaf through pulverizing, extracting in water or alcohol, and separating. Said extract along with proper medicinal additives can be used to prepare tablet, mixture, capsule, particle, or injection for decreasing blood pressure and blood fat, and treating arrhythmia, and diabetes and its complications.

Description

technical field [0001] The invention relates to a pure natural medicinal preparation with persimmon leaf extract as an active ingredient and its application in treating hypertension, coronary heart disease and diabetes. Background technique [0002] Persimmon leaves are the fresh or dried leaves of Diospyros kaki L., a plant of the family Persimmon family. The present invention has carried out a large number of researches on the drug, and found that the product can significantly reduce blood pressure in rats, increase coronary flow, resist arrhythmia caused by myocardial ischemia, significantly reduce blood lipids in rats, and can antagonize the rise of adrenaline. Sugar effect and reduce blood sugar in diabetic mice induced by streptozotocin, in addition, it can also significantly improve glycolipid disorders, increase insulin secretion, protect and repair islet β cells, and has a greater effect on the treatment of diabetes, especially complications potential application v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/08A61K9/16A61K9/20A61K9/48A61P3/10A61P9/10A61P9/12A61K127/00
Inventor 黄仁彬蒋伟哲林兴焦杨张程修覃斐章罗昱澜邓航付书婕谢海源
Owner 黄仁彬
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