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Preparation method of alginate oligosaccharides

A technology of algin oligosaccharides and alginic acid, which is applied in the field of preparation of algin oligosaccharides, can solve problems such as difficult product control, over-oxidation, and environmental safety, and achieve the effects of reducing pollution, preventing over-oxidation, and reducing production costs

Inactive Publication Date: 2007-09-19
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is fast and the post-treatment is relatively simple, its disadvantages are that due to the use of higher temperatures, there is an over-oxidation problem, so the yield is low, and the product is difficult to control. In addition, organic solvents are required, and the cost is high. It will bring environmental safety problems, so the process needs to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] The preparation method of algin oligosaccharides in this embodiment comprises the following steps: adding water to alginic acid or its metal salt or the fragments of homomannuronic acid and homoguluronic acid prepared therefrom to dissolve or disperse it In water, its weight percent concentration is 0.5-15%. Add an oxidizing agent to the aqueous solution or suspension. The oxidizing agent can be selected from hydrogen peroxide, hypochlorous acid or hypochlorite, and which one to choose depends on the need. Heat the solution added with oxidant to 60-80°C in microwave equipment, keep it for 4-50 minutes, then cool the solution through cooling water, then pass the cooled solution through the nanofiltration membrane to concentrate the solution, and at the same time pass the solution through the nanofiltration membrane During the concentration process of the solution, part of the small molecular substances and unreacted oxidants in the solution are filtered out and removed, a...

Embodiment 1

[0017] Example 1: Dissolve 10.0 g of sodium alginate in a certain amount of distilled water, add an oxidizing agent according to the ratio of raw materials and oxidizing agent at 5:1, and add distilled water to the solution so that the concentration of sodium alginate is 1%. Three aliquots of this solution were maintained at 80° C. for 10 minutes, 20 minutes, and 30 minutes, respectively, with the assistance of radiation. Rapidly cool in cold water, centrifuge, take 3 μl of the supernatant and apply it for thin-layer chromatography analysis, and spray-dry 3 parts of the supernatant to obtain powders of 9.37g, 9.21g, and 8.92g, respectively. The results of thin-layer chromatography showed that the spots of the samples treated for 10 minutes were darker, and the ratio shift value of the front edge of the spots was small, while the samples treated for 30 minutes were slightly lighter in color, but the number of spots at the front edge was large, and the front edge was clear. The ...

Embodiment 2

[0018] Example 2: Dissolve 20.0 g of sodium alginate in a certain amount of distilled water, prepare 4 parts, add oxidizing agents according to the ratio of raw materials and oxidizing agents of 15:1, 10:1, 5:1, and 2:1 respectively, and add them to the solution Add distilled water to make the concentration of sodium alginate 2%. Four portions of this solution were maintained at 80° C. for 20 minutes each with the aid of radiation. Quickly cool in cold water, centrifuge, take 3 μl of the supernatant and apply it for thin-layer chromatography analysis, and spray dry 4 parts of the supernatant to obtain powders 19.20g, 19.11g, 18.95g, and 18.56g, respectively. The results of thin-layer chromatography showed that after the same treatment time, the more oxidant was added, the lower the average molecular weight of the product and the lower the yield. On the contrary, the higher the average molecular weight, the higher the yield.

[0019] The raw material used in the present inven...

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Abstract

A preparation method for alginate oligosaccharides includes following steps: adding the water to the alginic acid or metal salt or the produced high mannuronic acid, high guluronic acid section to dissolve or disperse in the water, adding it to the oxidant solvent in a radiation condition, heating the solution to 60-80 DEG C for 4-50 minutes, then cooling the solution, concentrating the solution by nanofiltration film, drying the concentrated liquid by spray. The invention improves the product quality by preventing the product over-oxidation by the radiation assistance in a lower temperature; effectively reduces the dosage of the oxidant by controlling the product degree of polymerization distribution in a low reaction temperature; avoids using organic solvent, reduces the product costs and saves the cost by nanofiltration film separation technique and spary drying technique which can be achieve the industry mass production. Therefore, the method has a practical application value.

Description

technical field [0001] The invention relates to a series of alginate oligosaccharides, in particular to a preparation method of alginate oligosaccharides. Background technique [0002] Alginate, also known as alginic acid polysaccharide, is a water-soluble acidic polysaccharide derived from the cell wall of brown algae. It is mainly extracted from brown algae such as kelp, macroalgae, and sargassum. It is composed of mannuronic acid and high gulu. Polymers formed by linking acids in different ways. Since kelp was introduced to my country from Japan in the 1950s, its aquaculture output has always ranked first in the world. In my country, kelp has been used for the production of alginate, mannitol and iodine for a long time. Among them, alginate is widely used in food, textile, medicine and health, chemical industry, and scientific research. At present, my country's production of alginate is second only to the United States, but most of its products are low-value primary pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/06C07H1/00
Inventor 欧昌荣汤海青娄永江徐大伦杨文鸽何仲
Owner NINGBO UNIV
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