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Injectable self-curable calcium phosphate bone tissue repairing material and its preparation method and application

A calcium phosphate bone and tissue repair technology, applied in medical science, prosthesis, etc., can solve the problems of risk of disease transmission, strong heat release, low porosity, etc. The effect of fast degradation

Inactive Publication Date: 2007-10-24
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, compared with the current bone defect repair materials such as autologous bone, allogeneic bone, and PMMA bone cement, calcium phosphate bone cement overcomes the following defects: ① The source of autologous bone is limited, and it is necessary to bear the pain of the second operation and the supply of bone. ② Allogeneic bone has immune reaction and potential risk of disease transmission; ③ The curing process of PMMA bone cement is accompanied by strong heat release, burning of surrounding tissues, non-biodegradation, and inability to firmly combine with bone tissue, etc.
However, calcium phosphate bone cement also has its shortcomings, such as low mechanical strength, and cannot be used to repair segmental defects in high load-bearing areas such as jawbone and femur; in addition, the porosity is low, which hinders the growth of cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Prepare tetracalcium phosphate (TTCP) powder as one of the raw materials;

[0036] (2) Mix the TTCP prepared in step (1) with the calcium hydrogen phosphate (DCPA) in an equimolar ratio, ball mill the mixture in an absolute ethanol medium, and dry at 80-100°C to obtain a powdered phosphate mixture;

[0037] (3) Mannitol is recrystallized as a pore-forming agent:

[0038] Take a certain amount of mannitol, dissolve it in a 50% (V / V) ethanol solution to make it supersaturated, then heat it to 60-70°C to promote the dissolution of mannitol, quickly cool it to stand still, and filter to obtain mannitol crystals.

[0039] (4) The powdered phosphate mixture of step (2) and the recrystallized mannitol of step (3) are thoroughly mixed at a mass ratio of 9:1 to obtain a solid phase of calcium phosphate bone tissue repair material;

[0040] (5) The mass ratio of chitosan, citric acid, glucose and collagen:

[0041] Chitosan:citric acid:glucose:collagen=1:5:5:0 dissolved in 100 pa...

Embodiment 2

[0045] (1) Prepare tetracalcium phosphate (TTCP) powder as one of the raw materials;

[0046] (2) Mix the TTCP prepared in step (1) with the calcium hydrogen phosphate (DCPA) in an equimolar ratio, ball mill the mixture in an absolute ethanol medium, and dry at 80-100°C to obtain a powdered phosphate mixture;

[0047] (3) Mannitol is recrystallized as a pore-forming agent:

[0048] Take a certain amount of mannitol, dissolve it in a 50% (V / V) ethanol solution to make it supersaturated, then heat it to 60-70°C to promote the dissolution of mannitol, quickly cool it to stand still, and filter to obtain mannitol crystals.

[0049] (4) The powdered phosphate mixture of step (2) and the recrystallized mannitol of step (3) are thoroughly mixed at a mass ratio of 6:4 to obtain a solid phase of calcium phosphate bone tissue repair material;

[0050] (5) The mass ratio of chitosan, citric acid, glucose and collagen:

[0051] Chitosan:citric acid:glucose:collagen=5:25:20:2 dissolved in 100 ...

Embodiment 3

[0057] Compared with the calcium phosphate bone tissue repair material in Example 1, the difference lies in:

[0058] (1) The mass ratio of phosphate mixture to mannitol is 7:3;

[0059] (2) The mass ratio of chitosan, citric acid, glucose and collagen is:

[0060] Chitosan: citric acid: glucose: collagen = 2:15:15:0.5;

[0061] (3) 2% by mass of hydroxyapatite powder is added to the solid phase, and then the calcium phosphate bone tissue repair material is prepared according to the solid-liquid ratio of 0.6g:1ml.

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Abstract

The invention discloses a curing calcium phosphate silicate bone tissue restoring material, comprising solid phase and liquid phase. Said solid phase comprises re-crystallized mannite and microcosmic salt mixture with calcium tetrahydrogen phosphate and calcium hydrogen orthophosphate of equal mole. Said liquid phase comprises chitose, citrate, glucose, collagen and water. The invention also relates to the method for preparing said restoring material and its application in bone tissue engineering mount preparation and restoring material for bone coloboma preparation. The restoring material can be degraded inside body, the strength in initial period is high, and degradation speed in later period is fast, so it is favorable to new bone tissue growth.

Description

Technical field [0001] The invention relates to a calcium phosphate bone repair material, in particular to an injectable self-solidifying calcium phosphate bone tissue repair material, and a preparation method and application thereof. Background technique [0002] The repair and reconstruction of bone defects has always been one of the important research topics in surgery and related disciplines. Clinically, for the repair of bone defects, autologous bone and biomaterials are often used to fill them, but all of them need to be surgically implanted in the body. In recent years, with the development of minimally invasive surgical techniques, such as percutaneous injection and arthroscopic surgery, the development and application of injectable bone repair materials has become an important direction of effort. The injectable bone repair material has the advantages of simple operation, small tissue damage, no damage to the blood supply of the repair area, and fewer surgical complicati...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54
Inventor 周长忍刘华李红
Owner JINAN UNIVERSITY
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