Injectable self-curable calcium phosphate bone tissue repairing material and its preparation method and application

Abstract

The invention discloses a curing calcium phosphate silicate bone tissue restoring material, comprising solid phase and liquid phase. Said solid phase comprises re-crystallized mannite and microcosmic salt mixture with calcium tetrahydrogen phosphate and calcium hydrogen orthophosphate of equal mole. Said liquid phase comprises chitose, citrate, glucose, collagen and water. The invention also relates to the method for preparing said restoring material and its application in bone tissue engineering mount preparation and restoring material for bone coloboma preparation. The restoring material can be degraded inside body, the strength in initial period is high, and degradation speed in later period is fast, so it is favorable to new bone tissue growth.

Description

Technical field

[0001] The invention relates to a calcium phosphate bone repair material, in particular to an injectable self-solidifying calcium phosphate bone tissue repair material, and a preparation method and application thereof. Background technique

[0002] The repair and reconstruction of bone defects has always been one of the important research topics in surgery and related disciplines. Clinically, for the repair of bone defects, autologous bone and biomaterials are often used to fill them, but all of them need to be surgically implanted in the body. In recent years, with the development of minimally invasive surgical techniques, such as percutaneous injection and arthroscopic surgery, the development and application of injectable bone repair materials has become an important direction of effort. The injectable bone repair material has the advantages of simple operation, small tissue damage, no damage to the blood supply of the repair area, and fewer surgical complicati...