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Buccal tablets having function of preventing decayed tooth and the preparing method thereof

A buccal tablet and efficacy technology, applied in the direction of medical preparations containing active ingredients, active ingredients of hydroxyl compounds, pharmaceutical formulas, etc., can solve the problems of local application of fluorine, peeling of oral mucosa, and affecting the appearance of teeth, etc., to achieve Easy to store, easy to carry, and convenient to take

Inactive Publication Date: 2007-10-31
SHANGHAI FISHERIES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among many anti-caries drugs, chlorhexidine and fluorine are recognized as the better ones. Chhebidine is a cationic surface-active broad-spectrum antibacterial agent. It has obvious affinity for bacteria and is easy to penetrate into the bacteria to achieve sterilization. purpose, but the effect of chlorhexidine in the oral cavity and inhibition of plaque is easily affected by many factors, such as PH, anionic surfactants, etc., and long-term use will cause various diseases such as oral mucosa peeling, ulceration, tongue, Side effects such as discoloration of teeth and dental silicate fillings affect the appearance of teeth; the application of fluoride to prevent caries is limited by the way of fluoride administration, and local application of fluoride has little effect. Some people have used vaccines and preservatives , glucan transferase in the prevention of dental caries, but it has not been applied clinically so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Heat and dissolve 15kg of β-cyclodextrin with 50kg of purified water until no precipitation occurs, add 4kg of tea polyphenols and grind it at a constant temperature until it becomes a paste, so that the tea polyphenols are included in the β-cyclodextrin, and freeze-dried to obtain tea polyphenols Phenol-β-cyclodextrin inclusion compound; dextrin 120kg, honeysuckle powder 5kg, knotweed powder 6kg, lecithin powder 2kg, vitamin C 0.2kg, xylitol 80kg, vanilla essence 0.015kg, add a certain amount of purification Mix with water, granulate with a granulator and dry to make granules; mix the granules, tea polyphenol-β-cyclodextrin inclusion compound and a small amount of water evenly, add 0.8kg of micropowder silica gel, and send it to the tablet press Tablet forming, drying to obtain the finished product.

Embodiment 2

[0033] Heat and dissolve 18kg of β-cyclodextrin with 60kg of purified water until no precipitation occurs, add 6kg of tea polyphenols and grind it at a constant temperature until it becomes a paste, so that the tea polyphenols are included in the β-cyclodextrin, and freeze-dried to obtain tea polyphenols Phenol-β-cyclodextrin inclusion compound; dextrin 180kg, honeysuckle powder 8kg, knotweed powder 6kg, lecithin powder 1.5kg, vitamin C 0.24kg, xylitol 100kg, citrus essence 0.01kg, add a certain amount Mix with purified water, granulate with a granulator and dry to make granules; mix the granules, tea polyphenol-β-cyclodextrin inclusion compound and a small amount of water evenly, add 1.2kg of micro-powdered silica gel, and send them into tablets Tablet forming by machine, drying to obtain the finished product.

Embodiment 3

[0035] Heat and dissolve 16kg of β-cyclodextrin with 50kg of purified water until no precipitation occurs, add 5kg of tea polyphenols and grind it at a constant temperature until it becomes a paste, so that the tea polyphenols are included in the β-cyclodextrin, and freeze-dried to obtain tea polyphenols Phenol-β-cyclodextrin inclusion compound; dextrin 160kg, honeysuckle powder 4kg, knotweed powder 10kg, lecithin powder 1.2kg, vitamin C 0.12kg, xylitol 120kg, mint flavor 0.008kg, add a certain amount Mix with purified water, granulate with a granulator and dry to make granules; mix the granules, tea polyphenol-β-cyclodextrin inclusion compound and a small amount of water evenly, add 1kg of micropowder silica gel, and send it into the tablet press Tablet forming, drying to obtain the finished product.

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PUM

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Abstract

The invention relates to a buccal tablet for treating caries and process for preparation, wherein the tablet is prepared from green tea polyphenols, giant knotweed rhizome powder, honeysuckle flower powder, vitamin C, soybean lecithin powder, xylitol, beta-cyclodextrin, starch gum, miropowdered silica gel and edible flavoring essence through steps of dressing, mixing and pelleting.

Description

technical field [0001] The invention relates to a buccal tablet with the effect of preventing dental caries and a preparation method thereof. Background technique [0002] Dental caries is a common oral disease, and the World Health Organization (WHO) lists it as the third largest non-communicable disease after cardiovascular disease and cancer. With the general improvement of people's living standards in our country, the sugar content in the diet and its intake continue to increase, making dental caries popular, and the incidence of dental caries accounts for about 50% of the total population, especially children's deciduous teeth suffering from dental caries is more obvious, up to If not treated in time after dental caries occurs, not only will secondary diseases such as periodontitis and periapical inflammation, but also affect the development of permanent teeth, making them irregularly arranged and causing May affect facial appearance, chewing and development. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/20A61P1/02A61K31/353A61K31/375A61K31/047
Inventor 江健周堃钟雄
Owner SHANGHAI FISHERIES UNIV
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