Anti-bacterial carboxy apatite composite coating, its preparing method and use

A technology of hydroxyapatite and composite coatings, which can be used in coatings, antifouling/underwater coatings, paints containing biocides, etc., and can solve problems such as infection and reduced efficacy of antibiotics

Inactive Publication Date: 2007-11-14
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Various antibiotics are normally used to solve the problem of bacterial infection during surgery, but the biofilm formed on the s

Method used

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  • Anti-bacterial carboxy apatite composite coating, its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 59.40 grams of hydroxyapatite and 0.60 grams of silver powder, then weigh 60 grams of zirconia balls with diameters of 2 mm, 3 mm, and 6 mm in a ratio of 2:2:1, put them into a ball mill bottle, and place them on the ball mill Ball milled for 2 hours to make hydroxyapatite powder containing 1 wt% silver. Vacuum plasma spraying technology was used to spray the mixed powder on the cleaned and sandblasted Ti-6Al-4V substrate with the spraying process parameters in Table 2. The antibacterial rates of the HA1 composite coating prepared by this method against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were 97%, 98% and 98%, respectively. See Figure 4 for the photos of colonies after 24 hours of bacterial culture on the surface of the specimen. According to the national standard GB15979-1995 "Product Antibacterial and Bactericidal Performance and Stability Test Method", the antibacterial rate ≥ 50% can report that the product has antibacterial ef...

Embodiment 2

[0022] The hydroxyapatite composite coating HA3 containing 3 wt% of silver was prepared by the same method as above. The antibacterial rates of HA3 composite coating against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were 99%, 99% and 99%, respectively. See Figure 4 for the photos of colonies after 24 hours of bacterial culture on the surface of the specimen. The results showed that the HA3 composite coating had a better antibacterial effect on Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa and positive bacteria such as Staphylococcus aureus. The in vitro cytotoxicity level of HA3 detected by MTT colorimetry was 0, indicating no cytotoxicity.

Embodiment 3

[0024] The preparation method of the hydroxyapatite composite coating HA5 with a silver content of 5 wt% is the same as in Example 1, and the antibacterial test and toxicity test are shown in Figures 1-3.

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Abstract

This invention relates to one kind of the antibacterial hydroxyl apatite compound coat, the preparation method and the application, its characteristic is the related compound coat is composed of the metal silver powder and the hydroxyl apatite powder, the metal silver powder is treated as the antibacterial increase ingredient, the silver powder' quality accounts for 1-5% of the compound coat, the particle size of the silver powder is 20-100mum, the particle size of the hydroxyl apatite powder is 10-100mum. This invention making the compound coat is realized by using the spray technics of the vacuum plasma. The provided compound coat has an above 95% excellent antibacterial effect on the coliform, the green pus pseudomonad and the golden yellow staphylococcus, and the cytotoxic rank in vitro of the compound coat is zero, has no cytotoxicity.

Description

technical field [0001] The present invention relates to an antibacterial hydroxyapatite composite coating, its preparation method and application, more precisely, it relates to the preparation of an antibacterial bone replacement material—an antibacterial plasma sprayed hydroxyapatite composite coating, its preparation and application, The invention belongs to the field of medical bioceramic coating. Background technique [0002] Hydroxyapatite has a chemical composition and crystal structure similar to the main minerals in human bones and teeth. It is the main inorganic component of human bone tissue and is a typical bioactive material. However, the mechanical properties of hydroxyapatite ceramics are poor, and its bending strength and fracture toughness are lower than those of human compact bone, so it is difficult to use in the bearing parts of the human body. Depositing hydroxyapatite ceramic coatings on titanium and other metal (alloy) substrates can overcome the britt...

Claims

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Application Information

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IPC IPC(8): C09D1/00C09D5/14A61L27/32
Inventor 陈益凯郑学斌季珩丁传贤
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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