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Microfluid centrifugal chip and its processing method

A microfluidic and chip technology, which is applied in the direction of centrifuges, separation of sediments by centrifugal force, instruments, etc., can solve the problems of no centrifugal application value and sample processing, etc., and achieve the advantages of easy on-chip integration, low cost, and good centrifugal effect Effect

Inactive Publication Date: 2007-12-12
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the centrifugation achieved by the top cover-driven flow cannot handle the continuous flow of samples, so it has no practical centrifugation application value

Method used

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  • Microfluid centrifugal chip and its processing method
  • Microfluid centrifugal chip and its processing method
  • Microfluid centrifugal chip and its processing method

Examples

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Embodiment 1

[0031] Example 1. Processing of microfluidic centrifugal chip:

[0032] The structure of the microfluidic centrifugal chip of the present invention is shown in Figs. 2 and 3, wherein Fig. 3 is a cross-sectional view of A-A in Fig. 2. The chip mainly includes a spiral microchannel 6 (in which the sample to be centrifuged moves) etched on the silicon wafer 7 and closed by a glass cover 8; an inlet 3 in the center of the spiral channel is used for sample injection; The chip contains two outlets, an outer outlet 4 and an inner outlet 5, which are used to extract samples after centrifugation. The thickness of the silicon wafer 7 is 400 μm; the thickness of the cover glass 8 is 500 μm; the width of the spiral micro channel 6 is 120 μm, and the depth is 60 μm. 23μm, the angle of the helix changes from 4π to 37π; the inlet 3, the outer outlet 4 and the inner outlet 5 are all through holes with a flared cross section, the port width is 568μm, and the diameter of the through hole is 100μm. ...

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Abstract

The invention relates to the making of a micro flow centrifugal chip. It comprises the chip base and cover plate, the base composed of a bended and continuous extending micro slot channel, with the curvature radius ranging 20-1000 micron, at least one inlet at the center of the micro slot channel, at least two outlets at the tail of the micro slot channel. It has a micro slot channel with micro curvature radius spinal, generating clutch acceleration speed to realize the centrifugal operation. It applies to micro processing, being able to realize excellent centrifugal effect, low in cost, and quick.

Description

Technical field [0001] The invention relates to a microfluidic centrifugal chip and a processing method thereof. Background technique [0002] Centrifugal technology is a specialized technology that uses centrifugal force to separate, concentrate and analyze substances based on the difference in sedimentation coefficient, diffusion coefficient and buoyancy density of substances. It is used in agriculture, medicine, food hygiene, biological products, bioengineering, and cell biology. It has been widely used in many fields such as science, molecular biology and biochemistry, especially in the essential processing links of biological sample pretreatment. [0003] In recent years, with the development of micromachining technology, microchips used in clinical laboratory research have received extensive attention. Micro Total Analysis Systems based on microchips have become a research hotspot in analytical chemistry, clinical medicine, and biology. However, the on-chip centrifugal oper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00B04B15/00B01D21/26
Inventor 李志宏王玮
Owner PEKING UNIV
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