Method for preparing temperature sensitive hydrogel with supramolecular structure

A molecular structure and sensitivity technology, applied in the field of functional polymer materials, can solve the problems of cross-linking agent and pore forming agent residue, poor biocompatibility, difficult removal of pore forming agent, etc., to achieve temperature sensitivity improvement, The effect of increasing the ratio of hydrophilic/hydrophobic groups and increasing the number of hydrogen bonds

Inactive Publication Date: 2007-12-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of this method is that the residual porogen is not easy to remove
[0015] The above methods for synthesizing NIPA hydrogel and the monomers that can be copolymerized with NIPA have t

Method used

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  • Method for preparing temperature sensitive hydrogel with supramolecular structure
  • Method for preparing temperature sensitive hydrogel with supramolecular structure

Examples

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example 1

[0030] Example 1: Dissolve 1.05 g of hydroxypropyl-β-cyclodextrin in 10 ml of deionized water, add 0.17 g of glycidyl methacrylate, and stir at room temperature for 10 minutes. Add 4.29 g of N-isopropylacrylamide, and stir for 20 minutes under a nitrogen atmosphere. Add 0.01 g of potassium persulfate, maintain a nitrogen atmosphere, and continue stirring for 5 minutes. Seal the container, place it in a 40°C water bath, and react for 6 hours. The resulting product is washed and soaked with deionized water to remove small molecules that are not reacted, and the mass concentration of N-isopropylacrylamide is 30%, and the molar concentration of hydroxypropyl-β-cyclodextrin and N-isopropylacrylamide is The ratio is 1:50, and the molar ratio of glycidyl methacrylate to N-isopropylacrylamide is 1:30, which is a supramolecular structure temperature-sensitive hydrogel. At 20°C, the swelling ratio is 30 times; at 50°C, 49% of water is lost in 10 minutes, and 61% of water is lost in 20...

example 2

[0031] Example 2: Dissolve 2.18g of β-cyclodextrin in 10ml of deionized water, add 0.44g of glycidyl methacrylate, and stir at room temperature for 25 minutes. Add 0.87 g of N-isopropylacrylamide, and stir for 10 minutes under nitrogen atmosphere. Add 0.1 g of potassium persulfate, maintain nitrogen atmosphere, and continue stirring for 10 minutes. Seal the container, place it in a 70°C water bath, and react for 24 hours. The obtained product was washed and soaked with deionized water to remove small molecules that were not reacted, so that the mass concentration of N-isopropylacrylamide was 8%, and the molar ratio of β-cyclodextrin to N-isopropylacrylamide was 1: 4. A temperature-sensitive hydrogel with a supramolecular structure at a molar ratio of glycidyl methacrylate to N-isopropylacrylamide of 1:2.5. At 20°C, the swelling ratio is 28.5 times; at 50°C, 43% of water is lost in 10 minutes, and 59% of water is lost in 20 minutes.

example 3

[0032] Example 3: Dissolve 1.44g of methyl-β-cyclodextrin in 10ml of deionized water, add 0.21g of glycidyl methacrylate, and stir at room temperature for 15 minutes. Add 2.5 g of N-isopropylacrylamide, and stir for 10 minutes under a nitrogen atmosphere. Add 0.1 g of ammonium persulfate, maintain nitrogen atmosphere, and continue stirring for 8 minutes. Seal the container, place it in a 55°C water bath, and react for 10 hours. The resulting product is washed and soaked with deionized water to remove small molecules that are not reacted, and the mass concentration of N-isopropylacrylamide is 20%, and the molar ratio of methyl-β-cyclodextrin to N-isopropylacrylamide 1:20, glycidyl methacrylate and N-isopropylacrylamide molar ratio of 1:15 supermolecular structure temperature sensitive hydrogel. At 20°C, the swelling ratio is 39.5 times; at 50°C, 60% of water is lost in 10 minutes, and 71% of water is lost in 20 minutes.

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Abstract

This invention discloses a method for preparing temperature-sensitive hydrogel with supermolecular structure. The present methods have such problems as residual corsslinking agent and pore-forming agent, low biocompatibility and low response speed. The method comprises: dissolving cyclodextrin in deionized water, adding glycidyl methacrylate, and stirring, adding N-isopropyl acrylamide, stirring in N2 atmosphere, adding initiator, sealing the container, heating in a water bath, reacting to prepare hydrogel, and soaking in deionized water after the reaction to obtain temperature-sensitive hydrogel with supermolecular structure. The method has such advantages as no need for corsslinking agent, easy operation, and no need for specific apparatus. The obtained hydrogel has supermolecular structure, and has such advantages as high temperature sensitivity and high biocompatibility.

Description

technical field [0001] The invention belongs to the field of functional polymer materials, and relates to a preparation method of a supramolecular structure temperature-sensitive hydrogel. Background technique [0002] Smart polymer hydrogels are a class of hydrogels that can respond to external stimuli. Temperature-sensitive hydrogels have attracted extensive research and applications because of their rapid response to small changes in temperature. Especially polymer hydrogels based on poly(N-isopropylacrylamide) (hereinafter referred to as NIPA). Because PNIPA hydrogel can respond quickly to small changes in the external environment, it has a wide range of application prospects. It is widely used in drug controlled release systems, contact lenses, chemical mechanical valves, sensing elements, etc. [0003] The synthesis of PNIPA polymer hydrogel mainly includes the following methods: free radical polymerization, interpenetrating polymer network (IPN) and an improved met...

Claims

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Application Information

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IPC IPC(8): C08F251/00
Inventor 邓建平杨万泰何钦雄
Owner BEIJING UNIV OF CHEM TECH
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