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Traditional Chinese medicine composition for treating benign prostate hyperplasia and application thereof

A prostatic hyperplasia and composition technology, which is applied in the direction of drug combination, drug delivery, and medical preparations containing active ingredients, can solve the problems of not being able to inhibit the BPH process, achieve oral bioavailability improvement, increase solubility and dissolution rate, Good anti prostatic hyperplasia effect

Inactive Publication Date: 2008-01-16
朱靖华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs used clinically to treat BPH are mainly 5α-reductase inhibitors and α-receptor blockers. Although they can improve symptoms, they cannot inhibit the process of BPH

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of total extract

[0042] Take 300g of Pygeum africana, crush it into coarse powder, add 6000ml of 80% ethanol, soak for 24 hours, heat and reflux for 30min, filter, and set aside the filtrate, add 3000ml of 80% ethanol to the residue and heat and reflux twice, each time for 1 hour, combine Extraction solution, ethanol is recovered under reduced pressure, spray-dried to obtain extract I;

[0043] Take 300g of pollen, make it into a paste with water, take 5g of commercially available yeast and dissolve it in water, stir well and mix with the pollen paste, control the temperature at 21±1°C, ferment for 24 hours, add 6000ml of 95% ethanol to soak and extract for 3 times , 24 hours each time, combine the extracts, recover ethanol under reduced pressure at 40°C, concentrate to a relative density of about 1.20, and freeze-dry at -40°C for 5 hours; sublimation temperature -15°C to -20°C for a total of 24 hours ; Dry at 30°C for 2 hours to obtain Ex...

Embodiment 2

[0046] Embodiment 2: Preparation of total extract solid dispersion

[0047] Take 20g of the total extract, add an appropriate amount of ethanol and water, and dissolve it by ultrasonic; take another 40g of polyvinylpyrrolidone, add 400ml of 95% ethanol, dissolve it by ultrasonic, mix the two evenly, recover the solvent under reduced pressure, and make it into a sticky substance. Freeze at -40°C for 5 hours; vacuum dry at a sublimation temperature of -15°C to -20°C for a total of 24 hours; dry at 30°C for 2 hours.

Embodiment 3

[0048] Example 3: Preparation of Total Extract Tablets

[0049] prescription:

[0050] Total Extract 200g Starch 50g

[0051] Microcrystalline Cellulose 70g Sodium Starch Carboxymethyl 20g

[0052] Magnesium Stearate 10g

[0053]

[0054] Makes 1000 pieces

[0055] Preparation method: According to the above prescription, weigh the total extract, starch, microcrystalline cellulose, and sodium carboxymethyl starch, pass through a 100-mesh sieve, mix well, use 75% ethanol to make soft material, 14-mesh granulation, 60°C Dried for 3 hours, granulated into 16 meshes, added with magnesium stearate, mixed evenly, pressed into tablets, and obtained.

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PUM

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Abstract

The invention discloses a Chinese herbal compound for treating benign prostatic hyperplasia and the preparation method. The invention is characterized in that the compound is prepared with raw materials of prunus African, pollen, dandelion and flos chrysanthemi indici (wild chrysanthemum flower) which are extracted and refined in a proper process. The invention also discloses preparation methods of various preparations which are produced with the compound and acceptable in pharmacy and applications of the preparations in the prevention field of the benign prostatic hyperplasia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating benign prostatic hyperplasia, its preparation method and its application in the field of benign prostatic hyperplasia prevention and treatment. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common disease of the elderly, the incidence rate is very low before the age of 40, 40% of the 50-year-old, 80% of the 80-year-old, and almost 100% by the age of 90 if the prostate histological examination is performed. Prostatic hyperplasia was found in 25% of patients, and urinary tract obstruction occurred in about 25% of patients and required drug and surgical treatment. [0003] Surgical treatment is an effective treatment, but there are certain risks, such as bleeding, infection, urinary incontinence, impotence, retrograde ejaculation, individual patients may need reoperation due to surgical failure or disease recurrence. It is now generally accepted that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P13/08
Inventor 朱靖华
Owner 朱靖华
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