Cefcapene pivoxil methanesulfonate

A technology of cefcapene pivoxil and mesylate, which is applied in the fields of medical preparations containing active ingredients, antibacterial drugs, organic chemistry, etc., can solve the problems of cefcapene pivoxil mesylate and so on, and achieve high efficiency The effect of recycling
CN101111498BInactive Publication Date: 2011-06-22SHIONOGI & CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHIONOGI & CO LTD
Publication Date
2011-06-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for producing cefcapene pivoxil methanesulfonate and, with the use thereof as an intermediate, corresponding hydrochloride. There is provided methanesulfonate of the compound of the formula ().
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Description

technical field

[0001] The present invention relates to the mesylate salt of cefcapene pivoxil. In detail, the present invention relates to the method for preparing cefcapene pivoxil hydrochloride via the mesylate. Background technique

[0002] Mode:

[0003] [chemical 1]

[0004]

[0005] Represented compound (I) (common name: cefcapene pivoxil; chemical name: 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-butenoyl (butenoyl)]amino-3 - carbamoyloxymethyl-3-cephem (cephem)-4-carboxylic acid pivaloyloxymethyl ester) is a cephalosporin-type (Sefeam series) antibacterial agent (reference: Patent Document 1). An antibacterial agent Foromox Tablets (trade name, Sionogi) containing its monohydrochloride monohydrate (common name: cefcapene pivoxil hydrochloride, reference: Patent Document 2) as an active ingredient is commercially available. In Patent Document 1, trifluoroacetate was synthesized from the protected form of the 7-amino group of cefcapene proxetil via the free form (cefcape...

Claims

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