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Application of fragrant solomonseal rhizome polyoses in preparing medicament for treating coronary disease

A polysaccharide and coronary heart disease technology of Polygonatum Polygonatum, applied in the application field of the effective part of Polygonatum Polygonatum in the preparation of drugs for treating coronary heart disease

Active Publication Date: 2008-02-27
天津世佳伟康科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no literature reports on the effect of polysaccharides from Polygonatum polysaccharides on coronary heart disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Therapeutic Effects of Polygonatum Polysaccharides on Experimental Myocardial Infarction in Rats Induced by Coronary Artery Ligation

[0011] 96 Wistar rats, weighing 260-280 g, were used for both sexes. Randomly divided into 6 groups, 16 rats in each group, respectively: sham operation group, model group, positive drug group (diltiazem hydrochloride 3mg / kg), polysaccharide polysaccharides in low dose (40mg / kg), medium dose (80mg / kg) , large dose (160mg / kg). Intraperitoneal injection of urethane (1000mg / kg) was anesthetized, the duodenum was separated, and the standard II-lead electrocardiogram (ECG) was recorded for 1 min in each group. The chest was routinely disinfected, and the fourth intercostal space on the left mid-clavian line was opened to expose the heart. The place about 2 mm away from the root of the left anterior descending coronary artery was ligated, sent back to the heart, and the chest cavity was closed. Record the lead II electrocardiogram ...

Embodiment 2

[0029] Example 2 Therapeutic Effect of Polysaccharide Polysaccharides from Polygonatum Polysaccharides on Dogs with Experimental Myocardial Infarction Caused by Coronary Artery Ligation

[0030] 36 healthy adult mixed breed dogs, weighing 12-17kg, both male and female. Randomly divided into 6 groups, 6 in each group, respectively: sham operation group (only threading without ligation), model group, diltiazem hydrochloride group (5mg / kg), low-dose polysaccharide polysaccharide group (10mg / kg), medium-dose Group (20mg / kg) and high-dose group (40mg / kg) (the dose of each dose group of Polygonatum Polysaccharides is determined by the "Effect of Polygonatum Polysaccharides on Experimental Myocardial Infarction in Rats Caused by Coronary Artery Ligation" experiment, the effective dose of rats Equivalent dose after conversion based on body surface area).

[0031]Anesthetized by 3% pentobarbital sodium 30mg / kg intravenously. The back position was fixed, the neck skin was cut, the end...

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PUM

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Abstract

The invention discloses a medical application of fragrant solomonseal rhizome polysaccharide, which is characterized by the following: resisting acute myocardial ischemia; lessening the degree of myocardial infarction obviously; reducing the scale and area of myocardial infarction and the release of myocardial enzyme; adopting the fragrant solomonseal rhizome polysaccharide to mate medically acceptable drug agent to do real usage.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines, and in particular relates to the application of effective parts of polygonatum polygonatum in the preparation of medicines for treating coronary heart disease. Background technique [0002] Coronary heart disease is a common cardiovascular disease in middle-aged and elderly people. The definition of coronary heart disease by the World Health Organization in 1979 is: myocardial damage caused by the imbalance between coronary blood flow and myocardial demand caused by functional changes or organic diseases of coronary arteries. The basic lesion of this disease is atherosclerosis in the coronary artery, the blood vessel that supplies nutrients to the heart muscle, so it is called coronary atherosclerotic heart disease, or coronary heart disease for short. Because of its high incidence and high mortality rate, coronary heart disease seriously endangers hum...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/899A61P9/10
Inventor 周亚伟
Owner 天津世佳伟康科技开发有限公司
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