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Method for preparing hydroxypropyl chitose nano particle

A technology of hydroxypropyl chitosan and nanoparticle, which is applied in the field of preparation of hydroxypropyl chitosan nanoparticle, can solve problems such as non-normal degradation and harm to human body, and achieve easy industrial production, mild reaction conditions, and production process simple effect

Inactive Publication Date: 2008-03-12
STATE GRID CORP OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are many methods for preparing chitosan particles, but most of them need to use cross-linking agents such as glutaraldehyde and formaldehyde, and emulsifiers such as Span-80. These substances cannot be degraded normally in the human body and are harmful to the human body. Harmful

Method used

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  • Method for preparing hydroxypropyl chitose nano particle

Examples

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Embodiment 1

[0010] The invention uses chitosan with a degree of deacetylation greater than 90% as a raw material, reacts it with excess propylene oxide under alkaline conditions to generate water-soluble hydroxypropyl chitosan. Measure 5ml of 1.0mg / ml hydroxypropyl chitosan solution in a three-necked flask, and slowly add 0.8mg / ml sodium polyphosphate solution dropwise under continuous magnetic stirring at a rate of 20-40 drops / min , stop dropping after the solution presents obvious opalescence.

[0011] It can be seen from the transmission electron microscope photo in Fig. 1 that the shape of the hydroxypropyl chitosan nanoparticles is relatively regular spherical, and the particle size is about 240nm.

Embodiment 2

[0013] Measure 5ml of 2.0mg / ml hydroxypropyl chitosan solution in a three-necked flask, and slowly add 0.8mg / ml sodium polyphosphate solution dropwise under continuous magnetic stirring at a rate of 20-40 drops / min , stop dropping after the solution presents obvious opalescence.

[0014] It can be seen from the transmission electron microscope photo in Fig. 2 that the hydroxypropyl chitosan nanoparticles present a relatively regular spherical shape, and the particle size is about 360nm. The particle size in Example 2 is larger than that in Example 1, which is mainly due to the increase in the concentration of the reactant hydroxypropyl chitosan.

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Abstract

The present invention relates to a hydroxypropyl chitosan nanometer particle and the preparation method for the hydroxypropyl chitosan nanometer particle. The nanometer particle is obtained through ion gel method, including: chitosan, sodium hydroxidand and isopropyl alcohol are mixed for stirring at room temperature; excessive propylene oxide is added in to the mixture for sufficient reaction at 60 DEG C; After the reaction, the Ph value is adjusted to be neutral; the reaction product is deposited by acetone and is cleaned for several times; then the product is dried in vacuum to get hydroxypropyl chitosan; with constant magnetic-force stirring, the water solution of hydroxypropyl chitosan is slowly added with sodium polyphosphate solution; when the solution is of opalescence, hydroxypropyl chitosan nanometer particles are obtained. The diameter of the hydroxypropyl chitosan nanometer particles obtained by the present invention can be controlled. The hydroxypropyl chitosan nanometer particles can be biologically degraded with in a non-toxic and harmless way. The preparation method is moderate. The hydroxypropyl chitosan nanometer particles can be used as the carriers of protein drugs.

Description

technical field [0001] The invention relates to a preparation method of hydroxypropyl chitosan nano particles with controllable particle size, good stability and can be used as drug carrier. Background technique [0002] Chitosan, chemically named β-(1,4)-2-acetylamino-2-deoxy-D-glucan, is the product of deacetylation of chitin, and is composed of glucosamine and acetylglucosamine structural units straight-chain polysaccharides. As a positively charged natural polysaccharide, chitosan itself has properties such as non-toxic, non-irritating, non-allergenic, and non-mutagenic. The degradation products are low-molecular-weight chitosan and glucosamine, which have good biophase compatibility and biodegradability. The modified chitosan is prepared into nano-microspheres or particles, which are used as drug delivery and controlled release carriers, which have the advantages of high drug encapsulation efficiency, strong stability and long drug release time, and can effectively av...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L5/08
Inventor 谢宇尚小娴
Owner STATE GRID CORP OF CHINA
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