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System for slowing and controlling to release gas bag floationg

A technology of airbags and airbag shells, which can be applied to medical preparations with inactive ingredients, inactive ingredients of oil/fat/wax, pharmaceutical formulations, etc. Effect

Inactive Publication Date: 2008-05-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing gastric floating system, with the release of the drug, the water continuously enters the system, and the floating performance decreases rapidly. Some preparations are always in a suspended state from the beginning, and the drug is easy to enter from the stomach as the food is eaten and the stomach is emptied. In the intestines

Method used

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  • System for slowing and controlling to release gas bag floationg
  • System for slowing and controlling to release gas bag floationg
  • System for slowing and controlling to release gas bag floationg

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An insoluble air sac shell

[0031] Weigh 30g of cellulose acetate and dissolve it in 500ml of acetone, then keep stirring until completely dissolved. Then dissolve 2g of PEG6000 in 30ml of pure water, and keep stirring until completely dissolved. Mix the above two solutions and stir well. Let it stand until the air bubbles in the solution are removed. Put the cured glue solution into the glue dipping tank. The temperature of the liquid in the glue dipping tank is 40°C, and the indoor environment temperature is 20-25°C. The capsule shell template is automatically glued, dried, shelled, and cut. That is, an insoluble air bag shell was obtained. Airbag shells with different inner diameters can be obtained according to different capsule shell templates.

Embodiment 2

[0033] Famotidine double-chamber single-layer balloon floating osmotic pump

[0034] In Example 1 as shown in Figure 1, the airbag shell I is a No. 0 enteric-coated capsule cap; the sustained and controlled release preparation III containing the drug is a famotidine single-layer osmotic pump tablet.

[0035] Famotidine Monolayer Osmotic Pump Tablets:

[0036] Tablet Prescription:

[0037] Famotidine 13.3%

[0038] Glucose 46.7%

[0039] Tragacanth 33.3%

[0040] Microcrystalline Cellulose 13.3%

[0041] 5% PVP ethanol solution appropriate amount

[0042] Magnesium Stearate Appropriate amount

[0043] 1000 pieces

[0044] Coating solution:

[0045] Cellulose acetate 30g

[0046] PEG4000 24g

[0047] Dibutyl phthalate 4g

[0048] Acetone 1000ml

[0049] water 100ml

[0050] Raw and auxiliary materials such as famotidine, glucose, tragacanth gum, microcrystalline cellulose, polyvinylpyrrolidone (PVPK90), magnesium stearate, etc. are pulverized until ...

Embodiment 3

[0056] Famotidine Gel Skeletal Airbag Floating Preparation

[0057] In Example 1 as shown in Figure 1, the airbag shell I is a No. 0 enteric-coated capsule; the sustained and controlled release preparation III containing the drug is a famotidine gel matrix tablet.

[0058] Famotidine Gel Matrix Tablets:

[0059] Tablet Prescription:

[0060] Famotidine 26.7%

[0061] Polyoxyethylene (molecular weight: 300,000) 33.3%

[0062] Sodium Chloride 6.7%

[0063] 5% PVP ethanol solution appropriate amount

[0064] Magnesium Stearate Appropriate amount

[0065] 1000 pieces

[0066] Raw and auxiliary materials such as famotidine, polyoxyethylene, sodium chloride, polyvinylpyrrolidone (PVPK30), magnesium stearate, etc. were pulverized until passing through an 80-mesh sieve. Weigh 40 g of famotidine, 10 g of sodium chloride, and 90 g of polyoxyethylene, and mix them uniformly. Use 5% PVP ethanol solution as a binder to make soft materials, pass through a 18-m...

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Abstract

The invention discloses a sustained-release and controlled-release balloon floating system, which can ensure that the drug can float at the top layer of the stomach contents after entering body and can not enter into small intestine along with the evacuation of foods, so as to improve the drug efficacy. The invention includes a balloon which can provide buoyancy to allow the system to be floated at liquid surface and a sustained / controlled-release preparation containing pharmacological active substances. The system includes three parts: a balloon shell I, gas II and the sustained-release and controlled-release preparation III containing drugs, wherein the gas II occupies one end of the balloon shell I, and the other end is occupied by the sustained-release and controlled-release preparation III, and the two are or are not separated by a partition board / diaphragm IV. The floating preparation which is prepared by the method of the invention can respectively and independently regulate the controlled-release time and the floating time during the prescription and process designs, and when the characteristics of one part of the two parts change, the characteristics of the other part do not be affected, thus, the exploration processes of the prescription and process can be greatly simplified.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an airbag type slow and controlled release floating system. Background technique [0002] Sustained and controlled release preparations can be divided into three types according to the type of drug release: fixed-rate, localized and timed-release. Fixed-rate release technology means that the preparation releases drugs in the body at a certain rate, which basically conforms to the law of zero-order release kinetics. The fixed-rate release can reduce the fluctuation of blood drug concentration and increase the compliance of patients with medication. Sustained and controlled release preparations belong to the fixed-rate release type, and commonly used technologies include: membrane-controlled and matrix-controlled release. The technologies that facilitate the realization of industrialized production include: multi-layer sustained-release tablet and coated susta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/12A61K47/14A61K47/32A61K47/34A61K47/38A61K47/44
Inventor 潘卫山张志宏杨星钢彭博孙光美关津
Owner SHENYANG PHARMA UNIVERSITY
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