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Pastille soft capsule and preparation method thereof

A technology for soft capsules and capsules, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of unqualified soft capsule disintegration, sedimentation of active ingredients, and migration of capsule substances, and achieves remarkable stability. and therapeutic benefits, effects that enhance beneficial effects

Inactive Publication Date: 2008-05-21
姚俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides a soft capsule containing Penyanjing extract as an active ingredient, which successfully solves the common problems of current soft capsule preparations, such as disintegration prolonging over time, and It can significantly enhance the beneficial effect of Penyanjing, and has significant stability and therapeutic advantages compared with current marketed products
[0010] The object of the present invention is to provide a kind of Penyanjing soft capsule pharmaceutical preparation, especially the soft capsule preparation containing Penyanjing, which overcomes the defects of existing Penyanjing oral preparations, and overcomes the disintegration that often occurs in soft capsules Poor stability issues such as unqualified, substance migration in the capsule, active ingredient sedimentation, and content ingredient leakage, and enhanced the beneficial effect of Penyanjing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1: the preparation of potyanjing extract

[0096] Take 1250g of Lonicera vine, 1250g of Spatholobus spatholobus, 1250g of dog ridge, 500g of dandelion, 500g of motherwort, 500g of plantain, 300g of red peony, 300g of Chuanxiong, add 8 times the amount of water to decoct, combine the decoction, and filter , the filtrate is concentrated to a relative density of 1.2 to 1.4, mixed with a certain concentration of ethanol, left to stand, the supernatant is filtered, the ethanol is recovered, concentrated into a thick paste, and dried to obtain the potyanjing extract.

Embodiment 2

[0098] Bonyanjing Extract: 0.25g

[0099] Soybean oil: 0.09g

[0100] Tween-80: 0.09g

[0101] Beeswax: 0.005g

[0102] Hydrogenated palm oil: 0.01g

[0103] Soy Lecithin: 0.005g

[0104]

[0105] Makes 1 capsule (0.45g)

[0106] Preparation Process

[0107] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.

[0108] Take the Penyanjing extract in Example 1, grind it into a fine powder that can pass through a 200-mesh sieve, add it to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not be less than 20 minutes, as the standby solution 2.

[0109] Take the prescribed amount of soybean oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 50 degrees; pour the solution into the above standby solution 2, stir evenly again, pass through the co...

Embodiment 3

[0111] Bonyanjing extract: 0.25g

[0112] Corn oil: 0.20g

[0113] Tween-80: 0.025g

[0114] Beeswax: 0.005g

[0115] Hydrogenated palm oil: 0.01g

[0116] Soy Lecithin: 0.01g

[0117]

[0118] Make 1 capsule (0.5g)

[0119] Preparation Process

[0120] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.

[0121] Take the Penyanjing extract in Example 1, grind it into a fine powder that can pass through a 180-mesh sieve, add it to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not be less than 20 minutes, as the standby solution 2.

[0122] Take the prescribed amount of corn oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 45 degrees; pour the solution into the above standby solution 2, stir evenly again, pass through the colloid ...

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PUM

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Abstract

The invention provides a novel soft capsule for curing pelvic inflammation, comprising matrix, suspending agent, wetting agent and surface active agent. The soft capsule of invention can increase the benefit effect of the pelvic inflammation curer obviously, at the same time overcome the problem of disintegration delay of the existing preparation. Compared with the existing market products, the invention has more obvious stability and curing advantage.

Description

technical field [0001] The invention relates to a drug soft capsule preparation containing extracts of honeysuckle, spatholobus and the like, which can significantly enhance the beneficial effect of the preparation. Background technique [0002] The current marketed dosage form of Penyanjing is granules, which can treat chronic pelvic inflammatory disease. It is prepared from the eight herbs of honeysuckle, spatholobus, dog ridge, dandelion, motherwort, plantain, red peony root and chuanxiong, after water extraction and alcohol precipitation, adding appropriate amount of auxiliary materials. The shortcomings of the preparation of granules are clear at a glance. Each oral administration is 12g, and the dosage is large. It needs to be boiled with boiling water before taking it, and the medicine itself is very bitter. Inconvenient to carry, etc. can easily lead to poor compliance of patients; and the granules are not easy to store, and are easy to absorb moisture and become mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/48A61K47/44A61P15/00
Inventor 姚俊华
Owner 姚俊华