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Method for preparing policresulen vaginal tablet and quality control method

A quality control method and polycresol technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., can solve problems such as contaminated clothing, inconvenient use of solutions, melting and loss of suppositories, etc., to promote disease Rehabilitation, high effective drug concentration, and the effect of reducing adverse reactions

Inactive Publication Date: 2008-08-06
王世锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of gynecological medicines, there are certain problems in their use and treatment; in addition, there are currently policresol suppositories and solutions on the market, but there are problems such as melting and loss of suppositories, contamination of clothes, and inconvenient use of solutions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] Example: prescription (1) polycresol sulfaldehyde 90g, lactose 80g, starch 180.0g, kaolin 120g, hypromellose 3.0g, silicon dioxide 20.0g, microcrystalline cellulose 60.0g, cross-linked polyvinyl Ketone 60g (plus 20g), magnesium stearate 4.0g to make 1000 tablets

[0019] (2) Method

[0020] A pretreatment: In addition to polycresol, lactose, starch, kaolin, silicon dioxide, crospovidone, microcrystalline cellulose, and magnesium stearate were respectively passed through a No. 7 sieve.

[0021] B polycresol vaginal tablet granule preparation: take by weighing polycresol and lactose, starch, kaolin, crospovidone 40g, microcrystalline cellulose of prescription quantity, with 2% hypromellose aqueous solution It is used as a binder, granulated with 16 mesh, dried at 60-70°C, granulated with a 16 mesh sieve, added with prescribed amount of magnesium stearate, silicon dioxide and 20 g of crospovidone, and mixed well. Measure the drug content of the granules and calculate the...

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PUM

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Abstract

The invention relates to a method for preparing novel gynecological policresulen vaginal tablet used for antisepsis and anti-inflammation and a quality control method thereof. The policresulen has broad-spectrum antibacterial effect on common gram-positive bacterium, gram-negative bacterium, fungus and some viruses, wherein, anaerobe trichomonas and monilia are particularly sensitive to the policresulen but vaginal lactobacilli flora is hardly effaced. The invention has the advantages that vagina local medication avoids or reduces possible untoward effect caused by systemic administration; highly effective concentration of the medicine on lesion site is in favor of developing therapeutic effect, effectively protecting physiological environment of the vagina and providing suitable life condition for good bacteria; wherein, prescription of 1,000 preparation units of the medicine is: 45-180g of the policresulen, 30-180g of filler lactose, 60-500g of starch, 50-500g of kaolin, 2-10g of bonding agent hypromellose, 6-50g of fluidizer silicon dioxide, 30-300g of disintegrating agent microcrystalline cellulose, 20-200g of polyvinyl polypyrrolidone and 1-10g of lubricant magnesium stearate.

Description

technical field [0001] The invention relates to a preparation method and quality control method of polycresol vaginal tablets, a new antibacterial and anti-inflammatory drug for gynecology. Background technique [0002] At present, trichomonas, bacteria, fungi and other bacterial infectious gynecological diseases seriously threaten women's health. Although there are many kinds of gynecological medicines, there are certain problems in their use and treatment. In addition, there are currently policresol suppositories and solutions on the market, but there are problems such as melting and loss of suppositories, contamination of clothes, and inconvenient use of solutions. [0003] The purpose of the present invention is to overcome the shortcomings of the existing varieties, provide a novel preparation with spectrum, high efficiency, quick effect, stability and good patient compliance and provide a quality control method. Contents of the invention [0004] The present inventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/795A61K31/185A61P15/02
Inventor 王世锋
Owner 王世锋
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