Digitalization pulsed-release electronic capsule

Abstract

A digital pulse electronic capsule for drug release relates to an oral drug delivery system. The digital pulse electronic capsule for drug release of the invention comprises a shell, a power supply, a starting switch, a digital pulse generating circuit and an array-type drug release device. The array-type release device comprises a drug release driver array and a drug storage bin array, while the drug release driver array consists of a plurality of drug release micro-actuators; the drug storage bin array consists of a plurality of micro drug storage bins. The digital pulse generating circuit generates a pulse electrical signal with specific strength according to preset frequency and intervals, and exerts the pulse electric signals respectively on a plurality of drug release micro-actuators in the array drug release device according to the preset time sequence and triggers the drug release micro-actuators to work, thus releasing the drug out of the micro drug storage bins. The invention provides an oral drug delivery system that can set drug delivery time according to the individual difference of the patients to release drugs for a plurality of times, which is not affected by the individual difference of the digestive tract environment.

Description

Technical field: [0001] The invention relates to an oral drug delivery device, which is used for releasing substances, such as medicine, food, markers, etc., in the digestive tract of animals or humans. Background technique: [0002] In recent years, due to the development of chronobiology and chronopharmacology, it has been found that various physiological indicators of people, such as blood pressure, blood sugar, blood adrenal cortex hormone and other hormones, have a circadian rhythm. It also shows rhythmic characteristics, such as angina pectoris, gastric acid secretion, migraine, epilepsy, arthritis, and rheumatism. During the high-incidence period, the incidence of myocardial infarction also has a similar situation. On the other hand, studies have shown that the circadian rhythm of the disease also causes diurnal changes in the pharmacokinetics and pharmacodynamics of therapeutic drugs. For the treatment of the above-mentioned rhythmic diseases, ideal therapeutic drug...

AI Technical Summary

Problems solved by technology

However, sustained-release preparations cannot pulse-release drugs within a specific period of time related to the law of the disease, and are slightly less effective in the treatment of regular diseases such as angina pectoris and asthma.

[0004] The current oral pulse preparation based on biomaterials can be dissolved after a preset time lag after entering the human body, and the time lag technology is used to respond to the patient's disease rhythm. However, although the current oral pulse drug delivery system already has a high time control accuracy, but the oral pulse drug delivery system based solely on biomaterial technology faces severe challenges of individual differences. Delay characteristics

The main reason is that there are individual differences in different patients, and the influencing factors include genetic factors, physiological factors, pathological factors, food structure, gastrointestinal micro-ecological environment, gastrointestinal motility characteristics, etc. There are different time lags in the body, so that it cannot accurately respond to the life rhythm of the patient's disease

(2) For the same disease, different patients have different life rhythms, so the curative effect of the same preparation in different patients is quite different. It is difficult for oral pulse preparations for mass production to accurately respond to life rhythms. There is an urgent need for a drug that can respond to patients Individual differences, an oral drug delivery system that can conveniently preset the release time

For example, the level of catecholamines in the body of hypertensive patients increases when they wake up in the morning, which is the most likely to cause problems. Generally speaking, the best time for administration is around three o'clock in the morning. The time when the level increases varies greatly. In the use of pulse controlled release tablets developed according to this statistical law, some patients have increased the patient's tolerance to the drug due to the pulse release of the drug at the wrong time, and instead reduced the therapeutic effect of the drug. Effect

In the field of oral drug delivery systems, oral pulse preparations that are purely based on biomaterial technology and are oriented to mass production have problems such as difficulty in accurately responding to life rhythms and obvious individual differences. Under the development trend of personalized medicine (Personality Medicine), it has become a A pressing problem in oral drug delivery systems

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