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Trimetazidine hydrochloride dispersible tablet and preparation method thereof

A technology of trimetazidine hydrochloride and dispersible tablets, which is applied in the field of trimetazidine hydrochloride dispersible tablets and its preparation, can solve problems such as difficulty in swallowing drugs, sudden onset of angina pectoris, etc., and achieve rapid disintegration, improved bioavailability, The effect of convenience

Inactive Publication Date: 2008-10-15
胡传良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic trimetazidine hydrochloride preparations are all ordinary tablets, but angina pectoris often occurs suddenly, and patients may have difficulty swallowing the medicine during acute onset. Therefore, it is necessary to develop a drug that is easy to take, can be chewed, sucked or dispersed with water. Suspension with good taste, especially trimetazidine hydrochloride for patients with swallowing difficulties or patients in special circumstances

Method used

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  • Trimetazidine hydrochloride dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: trimetazidine hydrochloride dispersible tablet

[0025] Trimetazidine Hydrochloride 20g

[0026] Microcrystalline Cellulose 100g

[0027] 20g pregelatinized starch

[0028] Hypromellose (additional) 10g

[0029] Stevia 6.0g

[0030] 2% (w / v) hypromellose solution (prepared with 50% ethanol) appropriate amount

[0031] Crospovidone (additional) 10g

[0032] Magnesium Stearate 1.5g

[0033]

[0034] A total of 1000 trimetazidine hydrochloride dispersible tablets were made

[0035] Preparation process: pass the trimetazidine hydrochloride raw material through a 100-mesh sieve, pass the rest of the auxiliary materials through a 80-mesh sieve, take the formula amount of trimetazidine hydrochloride, filler microcrystalline cellulose and pregelatinized starch, flavoring agent steviol and The added part of the disintegrating agent hypromellose is fully mixed evenly; wet granulation with 2% hypromell...

Embodiment 2

[0036] Embodiment 2: trimetazidine hydrochloride dispersible tablet

[0037] Trimetazidine Hydrochloride 20g

[0038] Microcrystalline Cellulose 115g

[0039] Starch 30g

[0040] Hypromellose (additional) 15g

[0041] Aspartame 2.0g

[0042] 2% (w / v) hypromellose solution (prepared with 50% ethanol) appropriate amount

[0043] Croscarmellose sodium (extra) 15g

[0044] Magnesium Stearate 2g

[0045]

[0046] A total of 1000 trimetazidine hydrochloride dispersible tablets were made

[0047] The trimetazidine hydrochloride raw material was passed through a 100-mesh sieve, and the rest of the auxiliary materials were passed through a 80-mesh sieve, wet granulated, and compressed into dispersible tablets. The specific preparation process was the same as in Example 1.

Embodiment 3

[0048] Embodiment 3: trimetazidine hydrochloride dispersible tablet

[0049] Trimetazidine Hydrochloride 20g

[0050] Microcrystalline Cellulose 100g

[0051] Lactose 35g

[0052] Hypromellose (additional) 12g

[0053] Stevia 00000000 6.0g

[0054] 2% (w / v) hypromellose solution (prepared with 50% ethanol) appropriate amount

[0055] Croscarmellose sodium (extra) 15g

[0056] Magnesium Stearate 1.5g

[0057]

[0058] A total of 1000 trimetazidine hydrochloride dispersible tablets were made

[0059] The trimetazidine hydrochloride raw material is passed through a 100 mesh sieve, the rest of the auxiliary materials are passed through an 80 mesh sieve, wet granulated, and compressed into dispersible tablets, the specific preparation process is the same as in Example 1

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Abstract

The invention relates to trimetazidine hydrochloride dispersible tablets and a preparation method thereof. The dispersible tablets have quick disintegrating speed; can be administered by ingestion, chewing or dispersing into uniform suspension with good taste by using water; have good compliance; and are particularly suitable for the elderly people, people with ingestion difficulty and patients under special conditions. In addition, the peak time of the dispersible tablet is earlier than the conventional tablet, thus fully indicating quick action characteristic.

Description

technical field [0001] The invention relates to the technical field of medicine and pharmacy, in particular to a trimetazidine hydrochloride dispersible tablet and a preparation method thereof. Background technique [0002] Trimetazidine Dihydrochloride (Trimetazidine Dihydrochloride) is an anti-anginal drug, chemical name: 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, chemical structural formula: [0003] [0004] Trimetazidine hydrochloride was developed by Servier Corporation of France, and was first listed in Japan by Kyoto Pharmaceutical Company of Japan in 1968. Its trade name is Vastarel, and it has been widely used in more than 90 countries so far. [0005] Trimetazidine hydrochloride has anti-epinephrine, norepinephrine and vasopressin effects, can reduce vascular resistance, increase coronary and circulatory blood flow, and promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P9/10
Inventor 胡传良徐成秦勇金春周自桂景瑞
Owner 胡传良
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