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Method for preparing fluorapatite/hydroxyapatite sosoloid nano-powder

A hydroxyapatite and nano-powder technology, which is applied in prosthesis, medical science and other directions, can solve problems such as difficulty in preparing fluorine-containing hydroxyapatite, and achieves a simple and easy preparation method, good controllability and simple operation. Effect

Inactive Publication Date: 2008-10-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For fluoroapatite, CN1475436 discloses a high-temperature solid-phase synthesis method, but this method is difficult to prepare nanoscale fluorine-containing hydroxyapatite

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] Calcium nitrate is dissolved in ethanol to form a concentration of 2mol / L calcium precursor; the molecular formula is PO(OH) 1 (OR) 2 Dissolve phosphoric acid in ethanol to form a phosphorus precursor with a concentration of 2 mol / L; mix the calcium precursor and the phosphorus precursor at a molar ratio of Ca / P=1.67 to form a mixed solution A;

[0021] Add trifluoroacetic acid into the mixed solution A at a molar ratio of F / Ca=0.20, and reflux for 12 hours to form a mixed solution B; add triethanolamine to the mixed solution B at a molar ratio of N:F=1:1, and heat Heating the mixture B above to make it spontaneously ignite until the dry rubber powder is formed, and the dry rubber powder is heat-treated at 700°C for 20 minutes to become fluorine-containing hydroxyapatite nanopowder, and the nominal molecular formula is Ca 10 (PO 4 ) 6 (OH) 0.01 f 1.99 , The average grain size is 92nm.

example 2

[0023] Calcium nitrate is dissolved in ethanol to form a concentration of 0.5mol / L calcium precursor; molecular formula such as PO(OH) 2 (OR) 1 Phosphoric acid is dissolved in ethanol to form a phosphorus precursor with a concentration of 6.0 mol / L; the calcium precursor and the phosphorus precursor are mixed in a molar ratio of Ca / P=1.67 to form a mixed solution A;

[0024] Add trifluoroacetic acid into the mixed solution A at a molar ratio of F / Ca=0.133, and reflux for 12 hours to form a mixed solution B; add diethanolamine to the mixed solution B at a molar ratio of N:F=1.5:1, and ignite the sol until The dry rubber powder is formed, and the dry rubber powder is heat-treated at 650°C for 4 hours to become a fluorine-containing hydroxyapatite nanopowder, and the nominal molecular formula is Ca 10 (PO 4 ) 6 (OH) 0.69 f 1.31 , The average grain size is 78nm.

example 3

[0026] Calcium nitrate is dissolved in ethanol to form a concentration of 3.5mol / L calcium precursor; molecular formula such as PO(OH) 2 (OR) 1 Dissolve phosphoric acid in ethanol to form a phosphorus precursor with a concentration of 2.0 mol / L; mix the calcium precursor and the phosphorus precursor at a molar ratio of Ca / P=1.55 to form a mixed solution A;

[0027] Add monofluorophosphoric acid to the mixed solution A at a molar ratio of F / Ca=0.01, and reflux for 48 hours to form a mixed solution B; add diethanolamine to the mixed solution B at a molar ratio of N:F=2:1, and ignite the sol until The dry rubber powder is formed, and the dry rubber powder is heat-treated at 500°C for 5 hours to become a fluorine-containing hydroxyapatite nanopowder, and the nominal molecular formula is Ca 9.3 (PO 4 ) 6 (OH) 1.907 f 0.093 , The average grain size is 45nm.

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Abstract

The present invention discloses a preparation method of fluorapatite / hydroxylapatite solid solution nanometer powder. The method takes calcium compound and part esterification phosphate or organic phosphate alcohol solution as the base and then adds fluoride compounds and organic amine so as to synthesize the fluorapatite / hydroxylapatite solid solution nanometer powder by the method of sol combustion self-spreading. The present invention solves the problems that the fluorapatite / hydroxylapatite solid solution nanometer powder is hard to prepare, and the fluorine content and the existence state of the fluorine are difficult to control, etc. The preparation method provided by the present invention has the advantages of simple operation, low cost and being easy for industrialization.

Description

technical field [0001] The invention relates to a preparation method of fluorapatite / hydroxyapatite solid solution nanopowder, which belongs to medical biological materials. Background technique [0002] Calcium phosphate material is a ceramic widely used as a hard tissue replacement material. It has various crystal forms, among which hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is the most commonly used one. It has been found that hydroxyapatite has excellent biological activity and is able to form chemical bonds with bone tissue. Furthermore, hydroxyapatite is known to be osteoconductive. However, due to the different application environments, in some applications that require long-term stability of calcium phosphate, such as the surface coating of metal substrates or ceramic artificial eyes under load-bearing conditions, its solubility is too large, which is easy to cause calcium phosphate dissolves, making the implant potentially ineffective. Therefore, it is nec...

Claims

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Application Information

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IPC IPC(8): A61L27/12
Inventor 程逵任常宝翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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