Method for preparing bone screw biological compound material

A composite material and biological technology, applied in medical science, surgery, etc., can solve the problem of not being able to shape arbitrarily, and achieve the effect of good combination and uniform dispersion.

Inactive Publication Date: 2008-11-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common feature of the above methods is the use of long fiber layering and pressing methods. The composite material prepared in this way is anisotropic and cannot b

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0013] Example 1:

[0014] 1) Dispersion and surface treatment of carbon fiber

[0015] The carbon fiber with an average length of 3mm is pre-oxidized with 55% nitric acid by mass concentration for 40 minutes, washed several times with deionized water, and dried, and then the dried carbon fiber is soaked in 100% dimethyl sulfoxide liquid for 12 hours Afterwards, dry at 120°C for 6 hours and then use;

[0016] 2) Preparation of composite materials

[0017] a. Combine the carbon fiber prepared in step 1) with Ca(NO 3 ) 2 ·4H 2 O, K 2 HPO 4 Add them to 40ml of acetic acid solution with a volume concentration of 2% in sequence, and disperse ultrasonically for 30 minutes at room temperature, the ultrasonic frequency is 100KHz, and wait for Ca(NO 3 ) 2 ·4H 2 O and K 2 HPO 4 After the carbon fiber is completely dissolved and the carbon fiber is completely dispersed, add 0.4ml of a 1% glutaraldehyde solution to the solution, stir it evenly to obtain a solution A; wherein the carbon fiber / ...

Example Embodiment

[0020] Example 2:

[0021] 1) Dispersion and surface treatment of carbon fiber

[0022] Pre-oxidize the carbon fiber with an average length of 3mm with nitric acid with a mass concentration of 60% for 50 minutes, wash it several times with deionized water, and then dry it, and then soak the dried carbon fiber in 100% dimethyl sulfoxide liquid for 20 hours Afterwards, dry for 7 hours at 120°C for use;

[0023] 2) Preparation of composite materials

[0024] a. Combine the carbon fiber prepared in step 1) with Ca(NO 3 ) 2 ·4H 2 O, K 2 HPO 4 Add them to 60ml of acetic acid solution with a volume concentration of 2% in sequence, and disperse ultrasonically for 50 minutes at room temperature, the ultrasonic frequency is 100KHz, and wait for Ca(NO 3 ) 2 ·4H 2 O and K 2 HPO 4 After the carbon fiber is completely dissolved and the carbon fiber is completely dispersed, add 0.5ml of 1% glutaraldehyde solution to the solution and stir it to obtain a solution A; wherein the carbon fiber / Ca(NO)...

Example Embodiment

[0027] Example 3:

[0028] 1) Dispersion and surface treatment of carbon fiber

[0029]Pre-oxidize the carbon fiber with an average length of 3mm with nitric acid with a mass concentration of 63% for 60 minutes, wash it several times with deionized water, and then dry it, and then soak the dried carbon fiber with 100% dimethyl sulfoxide liquid for 24 hours Afterwards, dry at 120°C for 10 hours for use;

[0030] 2) Preparation of composite materials

[0031] a. Combine the carbon fiber prepared in step 1) with Ca(NO 3 ) 2 ·4H 2 O, K 2 HPO 4 Add them to 50ml of acetic acid solution with a volume concentration of 2% in sequence, and disperse ultrasonically for 60min at room temperature, the ultrasonic frequency is 100KHz, and wait for Ca(NO 3 ) 2 ·4H 2 O and K 2 HPO 4 After the carbon fiber is completely dissolved and the carbon fiber is completely dispersed, add 0.6ml of 1% glutaraldehyde solution to the solution, stir it evenly to obtain A solution; where the carbon fiber / Ca(NO) pr...

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PUM

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Abstract

The invention provides a method for making a coaptation nail biological composite material, comprising the following steps of: firstly, soaking a carbon fiber with dimethyl sulfoxide liquid after pre-oxidizing the carbon fiber with nitric acid; then, orderly adding the carbon fiber and Ca(NO3)2.4H2O, K2HPO4 into acetic acid solution; after undergoing ultrasonic dispersion, adding glutaraldehyde solution to obtain solution A; extracting the solution A and adding chitosan; then placing in a ultrasound wave cleaning device to oscillate; and keeping stand to deaerate; slowly pouring the deaerated chitosan solution into a mould; placing the mould in NaOH solidification liquid to soak; placing the formed gel into a vacuum drying box to dry and solidify; and obtaining the desired product. The synthesized composite material has the advantages of higher flexural strength and compressive strength, even dispersion of the made composite material fiber, good combination of the fiber and a matrix interface, wherein the flexural strength of the composite material is between 35 and 90 MPa, the compressive strength is between 30 and 75 MPa, and bending modulus is up to between 250 and 320 MPa, and the flexural strength and flexibility of the material are higher than the flexural strength and flexibility of the single chitosan and hydroxyapatite, thereby having mechanical properties required by the coaptation nail.

Description

technical field [0001] The invention relates to a preparation method of a bone screw material, in particular to a preparation method of a biocomposite material used for repairing and replacing a metal bone screw. technical background [0002] Biological bone can be regarded as a composite material filled with nano-hydroxyapatite and polymer matrix. To find a suitable extracellular matrix material is one of the focuses of bone tissue engineering research. A good scaffold material can provide a space for cells to adhere and grow and reproduce, which is conducive to tissue regeneration. An ideal scaffold material must have multiple characteristics at the same time: a porous three-dimensional structure suitable for cell growth, good biocompatibility, biodegradability and mechanical properties matching the host tissue, etc. Considering these characteristics, many scaffold materials such as Degradable polymer materials (PLA, PGA, PLLA, etc.) and bioceramics (HA, HA / TCP, etc.) hav...

Claims

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Application Information

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IPC IPC(8): A61L31/12
Inventor 黄剑锋沈基显曹丽云李娟莹殷立熊
Owner SHAANXI UNIV OF SCI & TECH
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