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Method for preparing bone screw biological compound material

A composite material and biological technology, applied in medical science, surgery, etc., can solve the problem of not being able to shape arbitrarily, and achieve the effect of good combination and uniform dispersion.

Inactive Publication Date: 2008-11-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common feature of the above methods is the use of long fiber layering and pressing methods. The composite material prepared in this way is anisotropic and cannot be shaped arbitrarily. It can only be used for the replacement of wide bones such as skulls, not suitable for long and short bones. Regular bone repair and replacement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Dispersion and surface treatment of carbon fiber

[0015] Pre-oxidize carbon fibers with an average length of 3 mm with nitric acid with a mass concentration of 55% for 40 minutes, wash with deionized water several times, filter and dry, and then soak the dried carbon fibers in 100% dimethyl sulfoxide liquid for 12 hours Afterwards, dry at 120°C for 6 hours before use;

[0016] 2) Preparation of composite materials

[0017] a, the carbon fiber prepared in step 1) and Ca(NO 3 ) 2 4H 2 O, K 2 HPO 4 Add in 40ml of 2% acetic acid solution in volume concentration successively, ultrasonically disperse at room temperature for 30min, the ultrasonic frequency is 100KHz, after Ca(NO 3 ) 2 4H 2 O and K 2 HPO 4 After completely dissolving and carbon fiber is completely dispersed, add 0.4ml mass fraction to the solution and be 1% glutaraldehyde solution, after stirring evenly, A solution is obtained; wherein the carbon fiber / Ca(NO) prepared in step 1) 3 ) 2 4H 2 O / K ...

Embodiment 2

[0021] 1) Dispersion and surface treatment of carbon fiber

[0022] Pre-oxidize carbon fibers with an average length of 3 mm with nitric acid with a mass concentration of 60% for 50 minutes, wash with deionized water several times, filter and dry, and then soak the dried carbon fibers in 100% dimethyl sulfoxide liquid for 20 hours Afterwards, dry at 120°C for 7 hours before use;

[0023] 2) Preparation of composite materials

[0024] a, the carbon fiber prepared in step 1) and Ca(NO 3 ) 2 4H 2 O, K 2 HPO 4 Add to 60ml of acetic acid solution with a volume concentration of 2% in turn, ultrasonically disperse at room temperature for 50min, the ultrasonic frequency is 100KHz, and wait for Ca(NO 3 ) 2 4H 2 O and K 2 HPO 4 After completely dissolving and carbon fiber is completely dispersed, add 0.5ml mass fraction to the solution and be 1% glutaraldehyde solution, after stirring evenly, A solution is obtained; wherein the carbon fiber / Ca(NO) prepared in step 1) 3 ) 2 4...

Embodiment 3

[0028] 1) Dispersion and surface treatment of carbon fiber

[0029]Pre-oxidize carbon fibers with an average length of 3 mm with nitric acid with a mass concentration of 63% for 60 minutes, wash with deionized water several times, filter and dry, and then soak the dried carbon fibers in 100% dimethyl sulfoxide liquid for 24 hours Afterwards, dry at 120°C for 10 hours before use;

[0030] 2) Preparation of composite materials

[0031] a, the carbon fiber prepared in step 1) and Ca(NO 3 ) 2 4H 2 O, K 2 HPO 4 Add to 50ml of acetic acid solution with a volume concentration of 2% in turn, ultrasonically disperse at room temperature for 60min, the ultrasonic frequency is 100KHz, and wait for Ca(NO 3 ) 2 4H 2 O and K 2 HPO 4 After completely dissolving and carbon fiber is completely dispersed, add 0.6ml mass fraction to the solution and be 1% glutaraldehyde solution, after stirring evenly, A solution is obtained; wherein the carbon fiber / Ca(NO) prepared in step 1) 3 ) 2 4...

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PUM

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Abstract

The invention provides a method for making a coaptation nail biological composite material, comprising the following steps of: firstly, soaking a carbon fiber with dimethyl sulfoxide liquid after pre-oxidizing the carbon fiber with nitric acid; then, orderly adding the carbon fiber and Ca(NO3)2.4H2O, K2HPO4 into acetic acid solution; after undergoing ultrasonic dispersion, adding glutaraldehyde solution to obtain solution A; extracting the solution A and adding chitosan; then placing in a ultrasound wave cleaning device to oscillate; and keeping stand to deaerate; slowly pouring the deaerated chitosan solution into a mould; placing the mould in NaOH solidification liquid to soak; placing the formed gel into a vacuum drying box to dry and solidify; and obtaining the desired product. The synthesized composite material has the advantages of higher flexural strength and compressive strength, even dispersion of the made composite material fiber, good combination of the fiber and a matrix interface, wherein the flexural strength of the composite material is between 35 and 90 MPa, the compressive strength is between 30 and 75 MPa, and bending modulus is up to between 250 and 320 MPa, and the flexural strength and flexibility of the material are higher than the flexural strength and flexibility of the single chitosan and hydroxyapatite, thereby having mechanical properties required by the coaptation nail.

Description

technical field [0001] The invention relates to a preparation method of a bone screw material, in particular to a preparation method of a biocomposite material used for repairing and replacing a metal bone screw. technical background [0002] Biological bone can be regarded as a composite material filled with nano-hydroxyapatite and polymer matrix. To find a suitable extracellular matrix material is one of the focuses of bone tissue engineering research. A good scaffold material can provide a space for cells to adhere and grow and reproduce, which is conducive to tissue regeneration. An ideal scaffold material must have multiple characteristics at the same time: a porous three-dimensional structure suitable for cell growth, good biocompatibility, biodegradability and mechanical properties matching the host tissue, etc. Considering these characteristics, many scaffold materials such as Degradable polymer materials (PLA, PGA, PLLA, etc.) and bioceramics (HA, HA / TCP, etc.) hav...

Claims

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Application Information

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IPC IPC(8): A61L31/12
Inventor 黄剑锋沈基显曹丽云李娟莹殷立熊
Owner SHAANXI UNIV OF SCI & TECH
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