Corydalis saxicola total alkaloid extract injection powder injection and preparation method thereof

A technology of total alkaloids and alkaloids, which is applied in the field of medicine, can solve the problems of poor quality preparations, poor stability and clarity, and low active ingredient content, and achieve superior bioavailability, good market prospects, and social benefits , the effect of shortening the treatment time

Inactive Publication Date: 2008-12-03
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main problem of the statutory extraction method of total alkaloids of Litectinus chinensis (see 2002 State Drug Administration "National Compilation of Chinese Patent Medicine Standards" Internal Medicine Hepatobiliary Volume, pages 325-328) is that the intermediate process is cumbersome and leads to high-quality preparations in the later stage. (injection) difficult to control quality, poor stability and clarity
[0005] At present, Yanhuanglian injection, which is mainly composed of traditional Chinese medicine Yanhuanglian, is injected intramuscularly, and the therapeutic effect is slow. In addition, there are the following disadvantages. First, it is inconvenient to use. It is necessary to break the ampoule before each use. In this way, it is inevitable that more or less debris will fall into the ampoule; second, the production of water injection requires high temperature sealing, which will inevitably affect the stability of the drug; third, the main components of the drug are unstable when exposed to light; Fourth, the content of active ingredients in Yanhuanglian injection currently used clinically is not high, and the difference is large, and the drug effect is not easy to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Take 40Kg of the whole plant of Litectinus chinensis, grind it to a coarse powder, add 400Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0045] 2 Take the liquid, add 60Kg of salt (NaCl) under continuous stirring, carry out salting out, leave it for 10 hours, filter, collect and obtain 412g of rock yellow lotus alkaloid sulfate precipitate.

[0046] 3 Dissolve the precipitated alkaloids in 1 liter of ethanol, add 50 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 301 g of dried rockwort alkaloids.

[0047] 4. Dissolve the above-obtained littoria alkaloid in 2 liters of 20% hydrochloric acid aqueous solution, filter, decompress and concentrate the filtrate to dryness to obtain 316 g of littoria alkaloid hydrochloride.

Embodiment 2

[0049] 1. Take 80Kg of the whole rock lotus plant, grind it into a coarse powder, add 800Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0050] 2. Take the extract, add 120Kg of salt (NaCl) under continuous stirring, carry out salting-out, place for 10 hours, filter, collect and obtain 833g of rock yellow lotus alkaloid sulfate precipitate.

[0051] 3. Dissolve the precipitated alkaloids in 2 liters of ethanol, add 100 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 635 g of dry rock lotus alkaloids.

[0052] 4. Dissolve the above-obtained rockwort alkaloid in 4 liters of 20% hydrochloric acid aqueous solution, filter, decompress and concentrate the filtrate to dryness, and obtain 641 g of rockwort alkaloid hydrochloride.

Embodiment 3

[0054] 1. Take 120Kg of the whole rock lotus plant, grind it into a coarse powder, add 1200Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0055] 2. Take the extract, add 180Kg of salt (NaCl) under continuous stirring, carry out salting-out, place for 10 hours, filter, collect and obtain 1305g of rock yellow lotus alkaloid sulfate precipitate.

[0056] 3. Dissolve the precipitated alkaloids in 3 liters of ethanol, add 150 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 910 g of dried rockwort alkaloids.

[0057] 4. Dissolve the above-obtained littoria alkaloid in 6 liters of 20% hydrochloric acid aqueous solution, filter, decompress and concentrate the filtrate to dryness to obtain 964 g of littoria alkaloid hydrochloride.

[0058] The embodiment of total alkaloid preparation of Litectinus chinensis

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PUM

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Abstract

The invention discloses Corydalis saxicola Bunting total alkaloid injection and a preparation method thereof (including water injection, powder injection and transfusion). The Corydalis saxicola Bunting total alkaloid injection is prepared by the given method through addition or no addition of auxiliary materials into Corydalis saxicola Bunting total alkaloids prepared by the given method. The product of the Corydalis saxicola Bunting total alkaloid injection has a better treatment effect, a simple preparation technique, and good market prospect and social benefit.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical preparation of total alkaloids of Litectinus chinensis, and more specifically relates to a total alkaloids of Litrichum chinensis injection and a preparation method thereof, wherein the total alkaloids of Litrichum chinensis injection comprises water injection, powder Needle and infusion. Background technique [0002] Corydalis thalictrifolia (Corydalis thalictrifolia Franch., Radix Corydalis Thalictrifoliae), a synonym of Corydalis thalictrifolia. Rock berberine, perennial herb, root obconical, fleshy, single or clustered stem, 15-20 cm high, leaf stem basal, leathery leaf blade, and leaf-like compound leaves, small leaves mostly 3-lobed or 3-lobed, The apex of the last lobe is round and blunt, the raceme is terminal, the capsule is linear, membranous, yellow, 2-valved when mature, the seeds are small, and grows on rocks. Distribution and Guizhou and other moun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/66A61K9/19A61P1/16
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
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