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Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof

A technology for dispelling wind and relieving pain and composition, which is applied in the field of pharmaceutical composition, preparation method and quality control, and can solve the problems of drug resistance, obvious side effects and addiction in the body

Inactive Publication Date: 2008-12-03
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine such as analgesics is mostly used in the treatment of Fengxie headache. Taking medicine for a long time every month will easily cause the body to develop drug resistance and addiction, and the side effects are very obvious.

Method used

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  • Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof
  • Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof
  • Medicament composition for dispelling wind and relieving pain, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0055] Experimental example 1: Pharmacodynamics test on the effect of drug group on pain response caused by thermal stimulation

[0056] Drug group I (Chuanxiong 210g, Angelica dahurica 105g, Notopterygium 95g, Asarum 45g, Fangfeng 55g, Mint 520g, Nepeta 210g, Licorice 105g)

[0057] Drug group II (Chuanxiong 350g, Baizhi 140g, Notopterygium 190g, Asarum 100g, Fangfeng 140g, Mint 570g, Nepeta 350g, Licorice 140g)

[0058] Drug group III (Chuanxiong 272.7g, Baizhi 136.4g, Notopterygium 136.4g, Asarum 68.2g, Gentiana 102.3g, Mint 545.5g, Pueraria 272.7g, Licorice 136.4g)

[0059] Drug group IV (Chuanxiong 272.7g, Baizhi 136.4g, Notopterygium 136.4g, Asarum 68.2g, Fangfeng 102.3g, Mint 545.5g, Nepeta 272.7g, Licorice 136.4g)

[0060] Control group: commercially available Chuanxiong Gypsum Drink

[0061] Get Kunming mice, body weight 20 ± 18g, basal body temperature between 36 ~ 37 ℃, randomly divided into 4 groups, each group is SC15% fresh beer yeast suspension, after 4 hours ...

experiment example 2

[0068] (1) Experimental conditions

[0069] Instruments and reagents

[0070] Instrument electric constant temperature drying oven; Sartorius balance; KUDOS ultrasonic cleaner-SK3300H

[0071] Reagent dry extract powder and prepared granules, excipients (lactose, sucrose + dextrin, starch, microcrystalline cellulose, xylitol, mannitol), ethanol, crucible.

[0072] Preparation of granules

[0073] Weigh 5g of dry extract powder, 5g of powdered sugar and dextrin through a 40-mesh sieve; pass the dry extract powder and powdered sugar through a 40-mesh sieve for 3 times to make it evenly mixed; mix the dry extract powder and sugar Put the powder into a crucible, add ethanol dropwise (select or change the concentration according to the situation), and knead and knead with your fingers continuously, mix well until "hand knead into a ball, and then disperse when pressed"; for making soft materials, make them on a 14-mesh sieve Granules were put into an oven at 60°C for 3h.

[007...

Embodiment 1

[0131] Chuanxiong 272.7g, Baizhi 136.4g, Notopterygium 136.4g, Asarum 68.2g, Gentiana 102.3g, Mint 545.5g, Pueraria 272.7g, Licorice 136.4g

[0132] The pharmaceutical composition is prepared into pills by adding conventional auxiliary materials through conventional techniques.

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Abstract

The invention discloses a medicine composition for dispelling wind and relieving pain, a preparation method thereof and a quality control method thereof. The medicine composition comprises the following raw material medicines of Chuangxiong, angelica, notopterygium, asarum, root of gentian, mint, kudzu root and glycyrrhiza. The preparation method of the medicine composition comprises the following steps that: for the eight medicines, the Chuangxiong, the angelica, the notopterygium, the asarum, the divaricate saposhnikovia root and the glycyrrhiza are respectively added with water to be boiled, and the boiled solutions are mixed and filtered to prepare a medicinal liquor; the mint and fineleaf schizonepeta herb are added with water and distilled to extract volatile oil, the water solution left is filtered to obtain filtrate, and the filtrate and the medicinal liquor are mixed and concentrated to be clear extract; and the clear extract is taken out and added with common auxiliary materials to prepare the preparation clinically used by the prior method. The medicine composition of the invention has good curative effects of treating headache caused by pathogenic wind or symptoms such as chillness, fever and nasal obstruction, etc.

Description

field of invention [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a medicinal composition for dispelling wind and relieving pain, a preparation method and a quality control method. Background technique [0002] Headache is a common clinical symptom, which can appear alone or in various acute and chronic diseases, such as hypertension, brain tumor, and angioneurotic headache. Wherein exogenous headache is mostly because of exogenous evils such as feeling wind, cold, damp, heat, and based on wind evil. Headaches caused by wind pathogens include headaches, pains on the back of the neck, severe wind, or aversion to cold, nasal congestion, thin white tongue coating, floating pulse, etc., which bring great harm to people's work, study and life. inconvenient. At present, Western medicine such as analgesics is mostly used in the treatment of wind-induced headaches. Taking medicines every month for a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K36/538A61K9/16A61P25/04A61P25/06
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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