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Method for separating efficacy ingredient from solid body and semi-solid formulation

A technology for functional components and semi-solids, applied in the field of separation of functional components particles, can solve the problems of detection and analysis, no way to detect, application and approval, etc., and achieve the effects of high precision, easy operation, and system specification

Active Publication Date: 2008-12-31
랴오닝그레이티스트바이오파마슈티컬컴퍼니리미티드
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology lacks detection methods for some particles with special functional components, and there are some difficult separation problems: for example, for particles with special functions, there is no way to detect them through solubility separation because there is no corresponding solvent and due to the need to keep the biological activity of the microparticles of functional components, the separation method should be limited to the scope of physical methods; in addition, because the content of microparticles of functional components contained in some creams and gels is extremely small, some content can only reach Tens of micrograms, the particles are extremely small, and some particles even reach the nanometer level
All of these have brought difficulties to the separation of trace functional ingredient particles from creams or gels, ointments, suppositories, etc.
It also makes it impossible to carry out subsequent detection and analysis of functional component particles
[0004] This lack of an effective separation method also makes it impossible to detect and analyze the special functional component particles of some creams, gels and other ointment products, which in turn makes it impossible to determine whether the functional component particles are beneficial to human health or not. Either it works or it doesn't
[0005] This situation can also lead to some promising new products, which cannot be detected and analyzed due to the inability to separate the active ingredient particles from creams or gels, ointments, and suppositories, resulting in the lack of effective separation and detection methods for this product. It is not possible to apply for approval according to the requirements of the state

Method used

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  • Method for separating efficacy ingredient from solid body and semi-solid formulation
  • Method for separating efficacy ingredient from solid body and semi-solid formulation
  • Method for separating efficacy ingredient from solid body and semi-solid formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The separation of functional components in embodiment 1 Nuoka cream, gel, ointment dosage form and suppository

[0035] Verification example of the present invention selects Nuoka emulsifiable cream dosage form, Nuoka gel dosage form, Nuoka ointment dosage form and Nuoka suppository dosage form containing trace functional components developed by Shenyang Shengbaokang Biopharmaceutical Co., Ltd., according to the method of the present invention, respectively The four dosage forms were subjected to the separation experiment of trace functional components.

[0036] 1) Separation of functional components in Nuoka cream

[0037] Among them, the Nuoka cream under inspection belongs to the oil-in-water cream base, and the commonly used emulsifier triethanolamine, 16 / 18 alcohol, monoglyceride, stearic acid and other raw materials are mainly used, which meet the requirements of the national pharmacopoeia.

[0038] The key functional component particles of the Nocardia cream are...

Embodiment 2

[0143] The separation of keel powder in embodiment 2 keel powder emulsifiable paste

[0144] The most common medicinal keels are the bones or teeth of horses, sheep, cattle, pigs, deer, elephants, rhinos, camels, etc., and carnivores, which are often off-white. Dragon bone is regarded as one of the important medicines in traditional Chinese medicine. Li Shizhen’s "Compendium of Materia Medica" "Dragon" discusses "long bone" and its indications: hemiplegia, semen and old charm. Intense knots, children are frightened by heat.

[0145] The content of keel powder per gram in homemade keel powder cream is ≥400 μg, the content is low, the particle size is less than 150 μm, and it exists in the cream system. In this experiment, keel powder in keel powder cream was separated by physical methods and its content was determined.

[0146] Experimental steps:

[0147] 1. Preparation of keel powder cream

[0148] First pass the keel powder through a 100-mesh sieve to obtain keel particle...

Embodiment 3

[0176] The separation of nano-silver in the nano-silver gel of embodiment 3

[0177] Nano silver gel has anti-inflammatory and bactericidal effects. The main component is nano-silver in the gel, its diameter is only 8-10nm, and the content in the gel is only a few hundred micrograms. Therefore, the qualitative and quantitative inspection of nano-silver in the nano-silver gel has brought many difficulties. This time The test is to separate the nano-silver through some physical methods, and to conduct qualitative and quantitative tests.

[0178] Sample: nano-silver antibacterial hydrogel, specification: 3ml / bottle, nano-silver content ≥ 350μg per ml gel, Changchun Kexin Institute of Chemical Medicine and Equipment.

[0179] Experimental steps:

[0180] 1. Dilute, take the nano-silver gel, dilute it into 4 samples in a 10ml centrifuge tube according to the table below

[0181] Sample 1

Sample 2

Sample 3

Sample 4

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Nano silver content (μg) ...

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Abstract

The invention relates to a method for separating efficacy component particles from solid or semisolid preparations such as cream, jellies, ointments and suppository, etc. which are used for medicine, cosmetics, food and chemicals, etc. so as to be convenient for carrying out detection analysis to the efficacy component, wherein, the particles of the efficiency components are particles which are not water soluble and oil soluble, and have the particle size of between 2nm and 200 Mum.

Description

technical field [0001] The invention relates to a method for separating microparticles of functional components from solid and semi-solid preparations such as creams, gels, ointments and suppositories used in medicine, cosmetics, food, chemicals, etc., so as to facilitate the detection and analysis of functional components. Background technique [0002] In the fields of medicine, cosmetics, health food, chemicals, etc., there are widely existing paste products such as creams or gels, and some of these products contain trace functional ingredients. The detection and analysis of these trace functional ingredient particles is the guarantee It is an important part of people's safe use of medicines, skin care products and food health. It is also the main means of monitoring whether these products have efficacy or are harmful to human health. [0003] The current situation is that ointment products such as various creams and gels develop rapidly and are widely used. However, the...

Claims

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Application Information

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IPC IPC(8): G01N1/28
Inventor 张策洪晓明张轶石明生
Owner 랴오닝그레이티스트바이오파마슈티컬컴퍼니리미티드
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