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Radionuclide particle implantation medicine for cancer, use and preparation method thereof

A drug and nuclide technology, which is applied in the field of tumor nuclear medicine, can solve the problems of inability to exert anti-cancer effects, short drug action time, and limited treatment intensity, and achieve the effects of reducing systemic side effects, reducing standardization of treatment, and improving survival

Inactive Publication Date: 2009-01-07
江苏三和生物工程股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Slow-release chemotherapeutic particle implants: fluorouracil-PLLA has similarities with the present invention, and its advantage is that it can increase the local drug concentration and prolong the time for the chemotherapeutic drug to act on cancer cells, but the anti-cancer effect cannot be exerted if the drug is not released. There are still shortcomings such as short drug action time and drug resistance, and the improvement of treatment intensity is limited. Currently, it is used clinically to assist radioactive particle therapy

Method used

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  • Radionuclide particle implantation medicine for cancer, use and preparation method thereof
  • Radionuclide particle implantation medicine for cancer, use and preparation method thereof
  • Radionuclide particle implantation medicine for cancer, use and preparation method thereof

Examples

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Embodiment 1

[0046] A medicine for implanting nuclide particles for cancer treatment: it includes a composition formed by mixing a radionuclide capable of emitting beta rays and a biodegradable polymer material, and the ratio is 0.9-1.1mg with high biodegradability. The molecular material is equipped with a β-ray-emitting radionuclide with a radioactivity of 18.5~37MBq. In this embodiment, the β-ray-emitting radionuclide with a radioactivity of 18.5~37MBq and a mass of 0.9-1.1 can be used. mg of biodegradable polymer material can be mixed, or it can be mixed according to the above ratio, and the ratio can be specifically selected as follows: per 0.9 mg of biodegradable polymer material with a radioactivity of 18.5MBq can emit β Radiation radionuclide; per 0.9mg of biodegradable polymer material with a radioactivity of 37MBq can emit β-ray radionuclide; per 1.0mg of biodegradable polymer material with a radioactivity of 28MBq A radionuclide capable of emitting β-rays, or a radionuclide capable ...

Embodiment 2

[0049] A nuclide particle implanted medicine for cancer treatment, the implanted medicine is composed of a mixture of a radionuclide capable of emitting beta rays and a biodegradable polymer material, and the ratio is 0.9-1.1 mg of biodegradable The polymer material is equipped with a beta-ray-emitting radionuclide with a radioactivity of 18.5~37MBq. In this embodiment, the beta-ray-emitting radionuclide with a radioactivity of 18.5~37MBq can be combined with a mass of 0.9 ~1.1mg of biodegradable polymer materials for mixing, or mixing according to the above ratio, the ratio can be specifically selected as: per 0.9mg of biodegradable polymer material with a radioactivity of 18.5MBq of energy Β-ray-emitting radionuclide; each 0.9mg of biodegradable polymer material is equipped with a radionuclide capable of emitting β-ray with a radioactivity of 37MBq; each 0.95mg of biodegradable polymer material is equipped with a radioactivity It is 25MBq of beta-ray-emitting radionuclide, or ev...

Embodiment 3

[0054] 32 The application of the composition of P-CP and poly-L-lactic acid as a nuclide particle implantation medicine for the treatment of malignant solid tumors.

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Abstract

The invention relates to the drug implant of radionuclide particles for cancer therapy. The drug implant comprises composition which is composed of radionuclide which can emit Beta rays, and biodegradable high-molecular material. The compounding ratio is as follows: each 0.9-1.1 mg of the biodegradable high molecular material is proportional to radionuclide which can emit Beta rays with the radioactivity of 18.5 to 37.0 MBq. The composition of <32>P-CP and poly-L-lactic acid is taken as the drug implant of the radionuclide particles for the therapy of malignant solid tumors. The preparation method comprises the following steps: selecting colloidal chromic phosphate or calcium phosphate with the radioactive concentration of 3700 to 7400 MBq / ml and the chemical concentration of 0.5 to 4.14 mg / mal as the <32>P-CP, according to the proportion that <32>P-CP: PLLA is 18.5 to 37.0 MBq: 0.9 to 1.1 mg and according to the proportion that each gram of poly-L-lactic acid is proportional to 3 to 6 ml of anhydrous alcohol, adding anhydrous alcohol into the poly-L-lactic acid and mixing, then adding the <32>P-CP and mixing uniformly, obtaining the paste composition, grinding the paste composition to uniformly distribute the radioactivity into the medium, drying the composition at 60 DEG C to 70 DEG C, then further grinding the composition into powder, positioning the powder into a pressing machine, and pressing particles with the diameter of 0.8 to 1 mm and the length of 2 to 4 mm.

Description

Technical field: [0001] The invention belongs to the technical field of tumor nuclear medicine, and particularly relates to a nuclide particle implantation medicine for cancer treatment, its use and a preparation method thereof. Background technique: [0002] Radiopharmaceutical colloid 32 P-chromic phosphate (chromic phosphate, 32 P-CP) is the radionuclide used in the present invention, which is a nano-scale colloidal solution, which is an inert substance. Inject into the body cavity, mostly staying at the injection site, or evenly attached to the inner wall of the body cavity and the surface of the tumor tissue, or swallowed by the phagocytic cells of the reticuloendothelial system in the lymphatic vessels and lymph nodes adjacent to the tumor, making the radiocolloid more concentrated In and near tumor lesions, the indication is used to control cancerous pleural and ascites and adjuvant therapy for certain malignant tumors. Interstitial injection 32 P-CP treatment of pancreati...

Claims

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Application Information

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IPC IPC(8): A61K51/00A61K51/06A61P35/00A61K103/00A61K103/30
Inventor 刘璐黄培林王自正陈大明杨敏高海林聂琦黄鹰
Owner 江苏三和生物工程股份有限公司
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