39 results about "Drug Implants" patented technology

An ocular implant device that is insertable into either the anterior or posterior chamber of the eye to drain aqueous humor and/or to introduce medications. The implant can include a substantially cylindrical body with a channel member that regulates the flow rate of aqueous humor from the anterior chamber or introduces medications into the posterior chamber, and simultaneously minimizes the ingress of microorganisms into the eye.

The invention relates to the use of absorbable block copolymers with polyether and polyester units for preparing surgical implants which are suitable for the human or animal body, and the block copolymers in question. The block copolymers used according to the invention and those which are new according to the invention are characterised by high mechanical strength and rapid absorption kinetics.

An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.

Medical implants and methods useful in treating postoperative pain are described. The implants comprise one or more electrospun drug-loaded fibers, which fibers comprise a drug useful in the treatment of pain. The implants are implanted at sites of interest including joint capsules, bones, and subcutaneous spaces, and are secured with tissue flaps or fasteners.

The invention includes a device for inserting a medicament within a body cavity of a mammal, the device including a cartridge for containing the medicament therein, the cartridge including a housing, a retractable chamber disposed within the housing and having a lumen, a substantially stationary member disposed within the lumen of the retractable chamber and having a uniform cross-section sized to provide a sliding fit within the lumen to provide for retraction of the retractable chamber about the substantially stationary member upon actuation of the device, and means for retracting the retractable chamber about the substantially stationary member while maintaining the substantially stationary member in a substantially stationary position upon actuation of the device; the device further including means for activating the means for retracting the retractable chamber.

The invention includes an actuator for actuating a device for inserting a medicament within a body cavity of a mammal, the actuator including a handle case having a proximal portion for gripping and a distal portion including means for attaching the actuator to a cartridge for containing medicament, and means for creating a proximal to distal linear motion with respect to the handle case, wherein the cartridge includes a retractable chamber for containing the medicament disposed therein, a substantially stationary member and means for retracting the retractable chamber about the substantially stationary member while maintaining the substantially stationary member in a substantially stationary position.

The invention discloses a drug pressing machine for preparing small-diameter granular implants from powdery raw materials, including a machine frame, a mold frame, a hydraulic system, a forming mold, a vacuum drug collecting device, a control system and the like. The molding die is composed of a die, a punching pin, a punching pin fixing plate, and a guiding device. The vacuum drug collection device includes components such as a vacuum pump, a vacuum channel, and a drug collection box, which can realize the automatic collection of preparation particles. The control system is composed of programmable controller, photoelectric sensor, force sensor and instrument, etc., which can precisely control the pressure, mold movement direction and speed, time and position. The medicine pressing machine uses the powdery mixture as the raw material, presses it into granular implants with a diameter of 0.5-2mm, and puts them into the medicine collection box through vacuum suction, and the whole process is automatically completed. This medicine pressing machine can adjust various process parameters, mold hole number and hole diameter according to needs, and press dozens to hundreds of granular implants at a time. The extruded particles have high hardness, stable shape and smooth appearance.

The present invention provides for pharmaceutical preparations, devices, systems and methods for the treatment of otic diseases and conditions. In various embodiments, the preparations, devices, systems and methods enable sustained drug release for the treatment or prevention of hearing loss, infections, and other pathological conditions of cochlea and inner ear.

A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.

The present invention relates to a preparation method, uses and a use method of a dexamethasone implant for kidney, wherein the dexamethasone implant comprises dexamethasone or dexamethasone acetate, a degradable polymer material, and a water soluble auxiliary material. The preparation method comprises: crushing various materials, mixing, carrying out micro-spheroidization, carrying out mold pressing molding, and heating for a certain time at a proper temperature to prepare the cylindrical implant with a diameter of 0.2-0.9 mm and a length of 0.8-4 mm. According to the present invention, the implant has characteristics of smooth surface and uniform drug release in vivo, wherein the time for releasing 90% of the drug is 1 month to 1 year; and the implant can be implanted into the renal sac through a drug implanting needle so as to treat nephrotic syndrome, nephritis and other chronic kidney diseases.

A biodegradable drug implant includes a PLG matrix and a non-steroid anti inflammation drug, for example diclofenac sodium. The implant is inserted into the eye in the anterior chamber, for example in the ciliary sulcus, following eye surgery. A method for treating and or preventing inflammation of the eye following eye surgery includes placing the implant in the anterior portion of the eye.

The invention discloses new application of militarine in preparation of heparin antagonist. The molecular formula of the militarine in the invention is C34H46O17 and the chemical name is bis [4-(beta-D-glucopyranosoxy) benzyl]-2-isobutyl malate. The militarine provided by the invention can be prepared into dosage form suitable for clinical application, mainly including injection, granule, capsule, tablet, powder, pill, drug implants and etc. The effect of antagonize heparin is obvious. The pharmacological effect is similar to or identical with protamine. The invention has the advantage of no adverse reactions to human such as allergy and safety, and can be developed into the substitute of the protamine to be applied in clinic with good application prospect.

Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

The invention relates to an external auditory canal directional delivery anti-epidemic device with a height of 20-30mm, a lower part diameter of 12-22mm and a upper part diameter of 6-12mm, the anti-epidemic device has an upper part with a round solitary, is in the shape of a bullet and implanted with drugs. The anti-epidemic device provided by the invention is pinched into a slender strip, the slender strip is plugged into external auditory canals of two ears, and the anti-epidemic device automatically rebounds in the external auditory canals and makes contact with the walls of the external auditory canals and ear hairs. According to the invention, the drug implanted of the anti-epidemic device delivered in external auditory canal is not only absorbed by external auditory canal skin cells, but also the drug information of implanted drug smell (wave) , the drug smell (wave) is sensed by the external auditory canal cells and ear hairs, and the drug smell (wave) is delivered to a human body and is further delivered to nasal olfactory nerve cells through eustachian tubes of ears, so that the human body biological information effect is generated to effectively treat human body diseases.