7 results about "Drug Implants" patented technology

Disclosed herein are drug delivery implants configured to be implanted into the eye of a subject and serve as intraocular drug depots. The implants reside in an intraocular target site until activation, at which time the implants release the drug (or drugs) housed within the implant in a controlled release fashion. The internal components of the implants can be arranged to control the rate of elution of a drug within an internal reservoir, and can be retained within the implant through the use of various embodiments of retaining elements.

Provided herein are drug implants comprising Pamiparib, Olaparib, or Niraparib for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and Pamiparib, Olaparib, or Niraparib disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may be used for the treatment of a proliferative disease.

Provided herein are drug implants comprising Darolutamide for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and Darolutamide disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may be used for the treatment of a proliferative disease of the prostate.

A drug implant delivery device includes a needle; an implant guide comprising a channel that is coaxial with the needle and configured to receive a drug implant; a gate configured to releasably limit the drug implant from moving into the needle; a barrel; a spring-loaded assembly comprising an elastomeric component received in the barrel and a stylet extending coaxially with the channel; and an actuator comprising: a first arm operably coupled to the gate, and a second arm releasably engaged with the spring-loaded assembly, wherein the actuator is configured such that actuation of the actuator causes the first arm to move the gate such that the drug implant can be moved into the needle and the second arm to disengage from the spring-loaded assembly such that the stylet translates to move the drug implant through the needle and into an injection site.

The application belongs to the technical field of medical biomaterials, and relates to a controlled-release drug implant, a preparation method thereof and application of the controlled-release drug implant in preparation of a breast cancer postoperative adjuvant therapy drug. A PDLLA solution is collected on a receiver by electrostatic spraying to obtain a PDLLA barrier layer; a PTMC solution containing a first drug active ingredient is collected on the PDLLA barrier layer by electrostatic spinning to obtain a first PTMC drug-loaded layer; a PTMC solution is collected on the first PTMC drug-loaded layer by electrostatic spinning to obtain a PTMC spacer layer; a PTMC solution containing a second drug active ingredient solvent is collected on the PTMC spacer layer by electrostatic spinning to obtain a second PTMC drug-loaded layer, and the controlled-release drug implant is obtained. The application utilizes the drug barrier property of PDLLA and the surface degradation property of PTMC, accurately controls release of doxorubicin and paclitaxel at different time points, and realizes programmed sequential release of the two drugs.

Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally, provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.