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Tartary buckwheat biological flavone effervescent tablet and preparation method thereof

A technology of bioflavonoids and tartary buckwheat flavonoids is applied in the directions of drug delivery, drug combination, and pharmaceutical formulations, which can solve the problems of increasing product cost and dampness of effervescent tablets, and achieve the effects of preventing moisture absorption and deliquescence, increasing content and reducing production costs.

Inactive Publication Date: 2009-02-18
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Effervescent tablet is a solid preparation for internal or external use that can quickly generate air bubbles after being put into water to disintegrate the tablet. Most of the effervescent tablets, when the acid source and carbon source are in contact with the air, the moisture in the air will promote the acid source and carbon source of the effervescent tablet to generate water, so that the effervescent tablet can be damp, so it needs to be airtightly packaged during production , thus increasing the product cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Preparation of Tartary Buckwheat Flavonoid Extract

[0022] The dried grains, stems and leaves of tartary buckwheat (1:1 ratio of grains / stems and leaves) were extracted by bio-enzyme combined with water. First use cellulase to carry out enzymatic hydrolysis, the conditions are: temperature 60°C, pH value 6.5, time 1.5 hours, enzyme dosage is 0.1% of the buckwheat dosage (including grains and stems and leaves); after enzymolysis, add water to decoct and extract 3 times , add 8 times the amount of water each time, extract for 30 minutes, filter the extract with a 400-mesh filter cloth, collect the filtrate, and use a decompression device to concentrate the filtrate at 60°C to an extract with a relative density of 1.10-1.20, and then add a concentration of Dissolve it in 30% ethanol, and add it to the chromatographic column equipped with D141 macroporous adsorption resin. After standing for a certain period of time, wash it with distilled water until the effluent is de...

Embodiment 2

[0030] 1. Preparation of Tartary Buckwheat Flavonoid Extract

[0031] The dried grains, stems and leaves of tartary buckwheat (1:1 ratio of grains / stems and leaves) were extracted by bio-enzyme combined with water. First use cellulase to carry out enzymatic hydrolysis, the conditions are: temperature 65 ℃, pH value 6.0, time 1.5 hours, enzyme dosage is 0.2% of tartary buckwheat dosage (including grains and stems and leaves); after enzymolysis, add water to decoct and extract 3 times , add 10 times the amount of water each time, extract for 30 minutes, filter the extract with a 400-mesh filter cloth, collect the filtrate, and use a decompression device to concentrate the filtrate at 60°C to an extract with a relative density of 1.10-1.20, and then add a concentration of Dissolve it in 25% ethanol, and add it to the chromatographic column equipped with D141 macroporous adsorption resin. After standing for a certain period of time, wash it with distilled water until the effluent ...

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PUM

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Abstract

The invention discloses a buckwheat bioflavonoid effervescent tablet and a preparation method thereof. The effervescent tablet comprises the following components: 12 to 18 percent of buckwheat-contained flavonoid extractive, 10 to 30 percent of acid source, 10 to 20 percent of carbon source, 30 to 50 percent of a filling agent, 5 to 10 percent of water-soluble inclusion material, 0.1 to 0.5 percent of a lubricating agent and 2 to 6 percent of a sweetening agent, wherein the buckwheat-contained flavonoid extractive is prepared by the techniques such as a water extraction method and a biological enzyme method, the purification of macropore polymeric adsorbent, and the spray drying. The effervescent tablet includes the carbon source by the water-soluble inclusion material in the preparation process, and the acid source and other components are pelletized independently. The bioflavonoid of the buckwheat bioflavonoid effervescent tablet obtained by the method has high content and is not easily affected by damp.

Description

technical field [0001] The invention relates to a health food with buckwheat as a raw material and a preparation method thereof, in particular to a tartary buckwheat bioflavonoid effervescent tablet and a preparation method thereof. Background technique [0002] Tartary buckwheat is rich in bioflavonoids and other active ingredients. Modern research shows that bioflavonoids have good therapeutic effects on cardiovascular and cerebrovascular diseases, hyperlipidemia, and diabetes. At present, there are many health foods that use tartary buckwheat as raw materials, but most of the flavonoids added to these health foods are obtained by crushing and pulping or drying and milling. The content of flavonoids produced by these two methods is relatively low. And it contains a lot of impurities such as protein and sugar. The application document with the application number 200610113363.1 discloses a process for extracting and refining buckwheat total flavonoids. The process is to soa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61K9/46A61P3/06A61P3/10A61P9/00C12P1/00
Inventor 赵钢邹亮杨敬东胡一冰
Owner CHENGDU UNIV
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