Quality control method for Chinese medicinal composition for treating ichthyosis

A technology of composition and traditional Chinese medicine, which is applied in the field of content determination and identification of ingredients in traditional Chinese medicine preparations, and can solve the problems of not disclosing quality control methods, etc.

Inactive Publication Date: 2009-02-18
大连美罗中药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent does not disclose its quality control method. The present invention provides a quality control method for the above-mentioned invented drug on the basis of the invented drug preparation. By this method, the quality of the invented drug and the drug containing the same components can be controlled.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prescription: Sophora flavescens 44g, licorice 44g, rehmannia glutinosa 88g, windproof 44g, atractylodes 66g, clematis 66g, Kochia chinensis 66g, hemp seed 44g, ephedra 44g, safflower 44g, white fresh skin 66g, cicada slough 44g, angelica 66g , Chuanxiong 44g, Guizhi 44g.

[0036]Preparation method: Take the above fifteen flavors, take the whole amount of cinnamon sticks, angelica, Chuanxiong and half of the white fresh skin, and powder them into a fine powder; except for the safflower, add half of the remaining half of the white fresh skin and rehmannia glutinosa and other eleven flavors, add water to decoct 2 times, decoct the safflower for the second time, each time for 3 hours, combine the decoction and filter, the filtrate is concentrated into a clear paste with a relative density of 1.00-1.30, and the detection temperature is 50-80°C; mix the above fine powder with the clear paste Mix evenly, dry and pulverize into fine powder to obtain the drug to be tested.

[...

Embodiment 2

[0056] Embodiment 2 takes the pharmaceutical composition in embodiment 1

[0057] The identification method includes the following steps:

[0058] (1) Identification of licorice: Take 6g of this product, grind it finely, add 40ml of ethanol and 2ml of hydrochloric acid, heat and reflux on a water bath for 40 minutes, let it cool, filter, take the filtrate and concentrate it to 10ml, add 10ml of water, stir well, transfer to In a separatory funnel, extract twice with petroleum ether (60-90°C), 20ml each time, combine the petroleum ether extract and evaporate to dryness on a water bath, add 0.5ml of absolute ethanol to dissolve the residue, and use it as the test solution. Take another glycyrrhetinic acid reference substance, add absolute ethanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to thin-layer chromatography (Appendix VIB of Chinese Pharmacopoeia 2005 Edition), draw 8ul of the above-mentioned test solution and 5μl of the r...

Embodiment 3

[0075] Embodiment 3 takes the pharmaceutical composition in embodiment 1

[0076] The identification method includes the following steps:

[0077] (1) Identification of licorice: Take 10g of this product, grind it finely, add 40ml of ethanol and 2ml of hydrochloric acid, heat and reflux on a water bath for 50 minutes, let cool, filter, take the filtrate and concentrate it to 10ml, add 10ml of water, stir well, transfer to In a separatory funnel, extract twice with petroleum ether (60-90°C), 20ml each time, combine the petroleum ether extract and evaporate to dryness on a water bath, add 0.5ml of absolute ethanol to dissolve the residue, and use it as the test solution. Take another glycyrrhetinic acid reference substance, add absolute ethanol to make a solution containing 1mg per 1ml, as the reference substance solution. Test according to thin-layer chromatography (Appendix VI B of Chinese Pharmacopoeia in 2005), draw the above-mentioned need testing solution 5ul, reference s...

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PUM

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Abstract

The invention relates to a method for controlling the quality of a Chinese medicine composition for treating ichthyosis, which belongs to the field of quality control of Chinese medicine. The Chinese medicine composition consists of dittany bark, pericarpium zanthoxyli, radix rehmannia, Chinese atractylodes, divaricate saposhnikovia root, cicada slough, safflower, hemp seed, cassia twig, angelica, szechwan lovage rhizome, liquorice, lightyellow sophora root, Chinese ephedra and broom cypress fruit. The method is characterized in that the content of one or a plurality of compositions in the medicine composition can be determined by high performance liquid chromatography; and one or the plurality of the compositions in the medicine composition can be distinguished by thin layer chromatography. The method makes up the deficiency of the prior art, improves the quality control standard of the medicine composition, and has the advantages of simple and convenient method, accurate result and excellent reproducibility.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a method for measuring and identifying components in traditional Chinese medicine preparations. Background technique [0002] Ichthyosis (ichthyosis) is a group of hereditary skin diseases, mainly manifested as skin onychomycosis, ranging from fine phosphorous scales to crocodile skin-like changes. There is no good treatment for this disease at home and abroad. Western medicine mainly takes corresponding treatment measures according to different clinical types of ichthyosis. The purpose of treatment is to relieve symptoms, increase the water content of the stratum corneum and promote normal keratinization. Drugs used for systemic treatment are mainly vitamin A and 13-cis retinoic acid, etc.; 0.1% retinoic acid cream, 10% urea ointment or urea cream are commonly used for local treatment, but the curative effects are not satisfactory. Traditional Chinese medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P17/00G01N30/36G01N30/90A61K35/64
Inventor 张成海周文波刘志昆陈心姜伟石桂芳
Owner 大连美罗中药厂有限公司
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