Technique for preparing double-acetyl emodic acid sustained-release capsules

A diacetyl rhein, preparation technology, applied in the direction of capsule delivery, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of patient inconvenience, achieve long shelf life, increase drug stability, and simple process Effect
CN101371823BInactive Publication Date: 2010-09-15上海慈瑞医药科技股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
上海慈瑞医药科技股份有限公司
Publication Date
2010-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a technology for preparing diacetylrhein spansule. The technology is characterized in that: diacetylrhein, L-hydroxypropyl cellulose, mannitol and CMS-Na are taken, evenly blended, pelletized and dried; ethyl cellulose, polyethylene glycol and triethyl citrate are taken as raw materials; ethanol is used for preparing coated alcohol slurry; the obtained pill cores with drug are moved to a coating-granulating machine and injected with the prepared coated alcohol slurry to carry out the coating of pellets; the obtained pellets are filled into hard capsule shells by a capsule filling machine so as to obtain the diacetylrhein spansule. The preparation technology has the advantages that the diacetylrhein spansule has good release effect and can be taken only once per day; the preparation process is simple with easily accessible raw and auxiliary materials and applicable to mass production.
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Description

technical field

[0001] The invention relates to a preparation process of a diacetylrhein sustained-release capsule, which is used for treating symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases, and belongs to the technical field of pharmacy. Background technique

[0002] Diacetylrhein, chemical name 4,5-diacetyl-9,10-dihydro-9,10 dioxo-2-anthracene carboxylic acid, also known as diacerein (Diacerein), is osteoarthritis IL-1 Inhibitor, can induce cartilage production, has analgesic, anti-inflammatory and antipyretic effects. It is clinically used to treat symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases.

[0003] The currently clinically used diacetyl rhein preparations are mainly ordinary tablets and ordinary capsules. The drug release rate of these two common capsules belongs to normal release, in order to ensure the effective blood drug concentration, it needs to be taken twi...

Claims

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