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Technique for preparing double-acetyl emodic acid sustained-release capsules

A diacetyl rhein, preparation technology, applied in the direction of capsule delivery, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of patient inconvenience, achieve long shelf life, increase drug stability, and simple process Effect

Inactive Publication Date: 2010-09-15
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking medicine more times will bring a lot of inconvenience to patients

Method used

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  • Technique for preparing double-acetyl emodic acid sustained-release capsules
  • Technique for preparing double-acetyl emodic acid sustained-release capsules
  • Technique for preparing double-acetyl emodic acid sustained-release capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of Diacetylrhein Sustained Release Capsules

[0018]

[0019] Coating prescription: ethyl cellulose 20%; polyethylene glycol 1000 8%; triethyl citrate 0.08%

[0020] Process: Grinding diacetyl rhein, low-substituted hydroxypropyl cellulose, mannitol and sodium carboxymethyl starch to a fineness of 80 meshes;

[0021] Take 80g of diacetyl rhein, 40g of low-substituted hydroxypropyl cellulose, 80g of mannitol, and 30g of sodium carboxymethyl starch, mix them evenly, put them into pellets with a coating granulator, and wait until the pellets grow to a size of 18-22 mesh, take them out , placed in a dryer and dried at a temperature of 55°C;

[0022] Concentration of ethyl cellulose 20%, polyethylene glycol 1000 The concentration is 8%, the concentration of triethyl citrate is 0.08%, and the material is taken out, and the coating alcohol slurry is prepared with 80% ethanol.

[0023] Put the above-mentioned drug-containing pellet core into a coating granula...

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Abstract

The invention relates to a technology for preparing diacetylrhein spansule. The technology is characterized in that: diacetylrhein, L-hydroxypropyl cellulose, mannitol and CMS-Na are taken, evenly blended, pelletized and dried; ethyl cellulose, polyethylene glycol and triethyl citrate are taken as raw materials; ethanol is used for preparing coated alcohol slurry; the obtained pill cores with drug are moved to a coating-granulating machine and injected with the prepared coated alcohol slurry to carry out the coating of pellets; the obtained pellets are filled into hard capsule shells by a capsule filling machine so as to obtain the diacetylrhein spansule. The preparation technology has the advantages that the diacetylrhein spansule has good release effect and can be taken only once per day; the preparation process is simple with easily accessible raw and auxiliary materials and applicable to mass production.

Description

technical field [0001] The invention relates to a preparation process of a diacetylrhein sustained-release capsule, which is used for treating symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases, and belongs to the technical field of pharmacy. Background technique [0002] Diacetylrhein, chemical name 4,5-diacetyl-9,10-dihydro-9,10 dioxo-2-anthracene carboxylic acid, also known as diacerein (Diacerein), is osteoarthritis IL-1 Inhibitor, can induce cartilage production, has analgesic, anti-inflammatory and antipyretic effects. It is clinically used to treat symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases. [0003] The currently clinically used diacetyl rhein preparations are mainly ordinary tablets and ordinary capsules. The drug release rate of these two common capsules belongs to normal release, in order to ensure the effective blood drug concentration, it needs to be taken twi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/222A61K9/48A61P29/00A61P19/02
Inventor 金幸汤磊袁文艳王琰
Owner 上海慈瑞医药科技股份有限公司
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