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Composite isatis root orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and compound banlan, which is applied in the field of compound banlangen orally disintegrating tablets and its preparation, can solve the problems of high temperature required for extraction, long heating time, and affecting the efficacy of drugs, and achieve high social and economic benefits. benefit, avoid decomposition and damage, enhance the effect of curative effect

Inactive Publication Date: 2009-04-01
上海市脑血管病防治研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the preparation process of compound Radix isatidis capsules, Radix isatidis and Folium folium are extracted with ethanol and water, and there are certain problems, because indirubin and indigo in Radix isatidis and Folium folium are fat-soluble components, which cannot be completely extracted with water or ethanol. The required temperature is high, the heating time is long, and the damage loss of the relative active ingredient will be greater, so the curative effect of the drug is affected to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Recipe: Radix isatidis 600g, Daqingye 900g.

[0029] Preparation method: Weigh 600g of Radix Radix and 900g of Folium Isatidis according to the formula, crush them, add 300g of 50% ethanol to soak for 0.5h, extract with supercritical carbon dioxide at 30°C and 15MPa for 1h, collect the extract, and set aside; Combine the extract residues of Radix Isatidis and Folium Isatidis, add 50% ethanol to reflux for extraction twice, each time for 1 hour, combine the extracts, filter, and set aside; Combine the liquids, filter, concentrate to a specific gravity of 1.05, cool, add 75% ethanol to 70% alcohol under rapid stirring, and let stand for 12 hours. The ethanol precipitation liquid is combined with the Radix Radix Radix, Folium Isatidis extract and ethanol extract, and the ethanol is recovered Concentrate to a specific gravity of 1.05 and set aside; mix and dry the above three extracts, crush them, and weigh 15.75% of citric acid, 15.75% of sodium bicarbonate, 16.5% of cross...

Embodiment 2

[0031] Recipe: Radix isatidis 600g, Daqingye 900g.

[0032] Preparation method: Weigh 600g of Radix Radix and 900g of Folium Isatidis according to the formula, crush them, add 600g of 75% ethanol to soak for 1h, extract with supercritical carbon dioxide at 20°C and 20MPa for 1.5h, collect the extract, and set aside; Combine the extract residues of Radix Isatidis and Folium Isatidis, add 50% ethanol to reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and set aside; Combine the liquids, filter, concentrate to a specific gravity of 1.10, cool, add 85% ethanol to 70% alcohol under rapid stirring, and let stand for 12 hours. The ethanol precipitation liquid is combined with the Radix Radix Radix, Folium Isatidis extract and ethanol extract, and the ethanol is recovered Concentrate to a specific gravity of 1.10, and set aside; mix and dry the above three extracts, crush them, and weigh 15.00% of citric acid, sodium bicarbonate

[0033] 15.00%, cro...

Embodiment 3

[0035] Recipe: Radix isatidis 600g, Daqingye 900g.

[0036] Preparation method: Weigh 600g of Radix Radix and 900g of Folium Isatidis according to the formula, crush them, add 900g of 95% ethanol to soak for 1.5h, extract with supercritical carbon dioxide at 40°C and 30MPa for 2h, collect the extract, and set aside; Combine the extract residues of Radix Isatidis and Folium Isatidis, add 50% ethanol to reflux for extraction twice, each time for 2.5 hours, combine the extracts, filter, and set aside; Combine the liquids, filter, concentrate to a specific gravity of 1.15, cool, add 95% ethanol to 70% alcohol under rapid stirring, let stand for 12 hours, combine the ethanol extract with Radix Radix Isatidis, Folium Isatidis extract and ethanol extract, and recover ethanol Concentrate to a specific gravity of 1.15 and set aside; mix and dry the above three extracts, crush them, and weigh 14.25% of citric acid, 14.25% of sodium bicarbonate, 13.50% of cross-linked sodium carboxymethy...

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Abstract

The invention relates to a preparation method of a compound isatis root orally disintegrating tablet which is obtained by the supercritical fluid extraction and the conventional extraction of isatis root and dyers woad leaf. The compound isatis root orally disintegrating tablet improves the content of the active components indirubin and indigotin greatly, enhances the curative effect of drug and is more applicable to the clinical treatment and is used for warm disease fever, spot, wind hot cold, swollen and ulcered throat, epidemic encephalitis B, hepatitis and parotitis, and the compound isatis root orally disintegrating tablet has very high social benefit and economic benefit.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a compound isatidis orally disintegrating tablet and a preparation method thereof. technical background [0002] Banlangen is the dried root of Isatis indigotica Fort., a cruciferous plant. Radix isatidis is cold in nature and bitter in taste. Tool clearing away heat and detoxification, cooling blood and relieving sore throat, clearing heat and detoxifying, cooling blood and relieving sore throat. It is used for warm-toxin-spotted spots, purple-purple tongue, mumps, sore throat, rotten throat Dansha, big head plague, erysipelas, and carbuncle. [0003] Daqingye is the dried leaf of Isatis indigotica Fort., a cruciferous plant. Folium Folium is cold in nature and bitter in taste. With heat-clearing and toxic substances removing, removing heat from blood and eliminating spots. For warm pathogens entering the camp, high fever and coma, macule...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K36/315A61K9/20A61P11/04A61P29/00A61P31/12
Inventor 王桂清顾桢茂
Owner 上海市脑血管病防治研究所
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