Composite isatis root orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and compound banlan, which is applied in the field of compound banlangen orally disintegrating tablets and its preparation, can solve the problems of high temperature required for extraction, long heating time, and affecting the efficacy of drugs, and achieve high social and economic benefits. benefit, avoid decomposition and damage, enhance the effect of curative effect

Inactive Publication Date: 2009-04-01
上海市脑血管病防治研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the preparation process of compound Radix isatidis capsules, Radix isatidis and Folium folium are extracted with ethanol and water, and there are certain problems, because indirubin and indigo in Radix isatidis and Folium folium are fat-soluble compone

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0027] Example 1

[0028] Formula: Banlangen 600g, Daqingye 900g.

[0029] Preparation method: Weigh 600g of Radix Isatidis and 900g of Daqingye according to the formula quantity, crush, add 300g of 50% ethanol and soak for 0.5h, extract with supercritical carbon dioxide at 30℃ and 15MPa for 1h, collect the extract for later use; The extract residues of Radix isatidis and Daqingye were combined, and 50% ethanol was added for reflux extraction twice for 1 hour each time. The extracts were combined, filtered, and set aside; the above ethanol extraction residue was refluxed with pure water for extraction twice, 1.5 hours each time for extraction The liquid is combined, filtered, concentrated to a specific gravity of 1.05, cooled, 75% ethanol is added to 70% alcohol content under rapid stirring, and placed for 12 hours. The alcohol precipitation solution is combined with the Radix Isatidis extract and the ethanol extract to recover the ethanol Concentrate to a specific gravity of 1.05...

Example Embodiment

[0030] Example 2

[0031] Formula: Banlangen 600g, Daqingye 900g.

[0032] Preparation method: Weigh 600g of Radix isatidis and 900g of Daqingye according to the formula amount, crush, add 600g of 75% ethanol and soak for 1h, extract with supercritical carbon dioxide for 1.5h at 20°C and 20MPa, collect the extract and use it for later use; The extract residues of Radix Isatidis and Daqingye were combined, and 50% ethanol was added for reflux extraction twice for 1.5 hours each time. The extracts were combined, filtered, and set aside; the above-mentioned ethanol extraction residue was refluxed with pure water for extraction twice, each time was 2 hours for extraction The liquid is combined, filtered, concentrated to a specific gravity of 1.10, cooled, 85% ethanol is added to 70% alcohol under rapid stirring, and placed for 12 hours. The alcohol precipitant is combined with the Radix Isatidis extract and the ethanol extract to recover the ethanol. Concentrate to a specific gravity ...

Example Embodiment

[0034] Example 3

[0035] Formula: Banlangen 600g, Daqingye 900g.

[0036] Preparation method: Weigh 600g of Radix isatidis and 900g of Daqingye according to the formula quantity, crush, add 900g of 95% ethanol and soak for 1.5h, extract with supercritical carbon dioxide at 40℃ and 30MPa for 2h, collect the extract and use it for later use; The extract residues of Radix Isatidis and Daqingye were combined, and 50% ethanol was added for reflux extraction twice, 2.5 hours each time. The extracts were combined, filtered, and reserved; the above ethanol extraction residue was refluxed with pure water for extraction twice, 2.5 hours each time, and extracted The liquid is combined, filtered, concentrated to a specific gravity of 1.15, cooled, and 95% ethanol is added under rapid stirring to an alcohol content of 70%, and placed for 12 hours. The alcohol precipitant is combined with the extracts of Radix Isatidis, Daqingye and the ethanol extracts to recover the ethanol. Concentrate to a...

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PUM

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Abstract

The invention relates to a preparation method of a compound isatis root orally disintegrating tablet which is obtained by the supercritical fluid extraction and the conventional extraction of isatis root and dyers woad leaf. The compound isatis root orally disintegrating tablet improves the content of the active components indirubin and indigotin greatly, enhances the curative effect of drug and is more applicable to the clinical treatment and is used for warm disease fever, spot, wind hot cold, swollen and ulcered throat, epidemic encephalitis B, hepatitis and parotitis, and the compound isatis root orally disintegrating tablet has very high social benefit and economic benefit.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a compound isatidis orally disintegrating tablet and a preparation method thereof. technical background [0002] Banlangen is the dried root of Isatis indigotica Fort., a cruciferous plant. Radix isatidis is cold in nature and bitter in taste. Tool clearing away heat and detoxification, cooling blood and relieving sore throat, clearing heat and detoxifying, cooling blood and relieving sore throat. It is used for warm-toxin-spotted spots, purple-purple tongue, mumps, sore throat, rotten throat Dansha, big head plague, erysipelas, and carbuncle. [0003] Daqingye is the dried leaf of Isatis indigotica Fort., a cruciferous plant. Folium Folium is cold in nature and bitter in taste. With heat-clearing and toxic substances removing, removing heat from blood and eliminating spots. For warm pathogens entering the camp, high fever and coma, macule...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K36/315A61K9/20A61P11/04A61P29/00A61P31/12
Inventor 王桂清顾桢茂
Owner 上海市脑血管病防治研究所
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