Nano-calcium phosphate biological active ceramic material containing silicon dioxide and preparation method thereof

Abstract

The invention provides a nanometer calcium phosphate bioactive ceramic material containing silicon dioxide and a method for preparing the same. The method for preparing the nanometer calcium phosphate bioactive ceramic material containing the silicon dioxide comprises the following steps: firstly, synthesizing an aqueous dispersion liquid of nanometer calcium phosphate by a liquid phase method; secondly, catalyzing and hydrolyzing ortho silicate ester compounds in the aqueous dispersion liquid, and performing gelatination to generate the silicon dioxide coating on the surface of the nanometer calcium phosphate; and thirdly, performing drying and high temperature calcination to obtain the nanometer calcium phosphate bioactive ceramic material containing the silicon dioxide. The direct agglomeration in the nanometer calcium phosphate is avoided in the process of drying and calcining after the surfaces of nanometer calcium phosphate particles are coated with the silicon dioxide, thus the original nanometer scale structure is kept; at the same time, the silicon dioxide coated on the surfaces of the calcium phosphate particles endows the ceramic material with better biological reactivity in organisms in comparison with the common nanometer calcium phosphate.

Description

technical field [0001] The invention relates to a novel inorganic biomaterial used for repairing and filling bone tissue defects in surgical operations and a preparation method thereof. Background technique [0002] Bioceramics have undergone a transformation process from inert bioceramics such as alumina and zirconia ceramics to degradable bioceramics such as tricalcium phosphate ceramics and bioactive bioceramics such as hydroxyapatite ceramics. In recent years, with the development of regenerative medicine research and tissue engineering technology, there are higher requirements for the performance of biomaterials. Some scholars have proposed the concept of the third generation of biomaterials, and believe that the new generation of biomaterials should be both biologically active and degradable. Studies have found that some silicon-containing bioglasses have both properties, and their biological activity is reflected in the induction of bone-like apatite in simulated bod...

AI Technical Summary

Problems solved by technology

[0006] The nano-calcium phosphate bioactive ceramic material containing silicon dioxide of the present invention is made by sintering the nano-calcium phosphate precursor coated with silicon dioxide on the surface. , to prevent nano-calcium phosphate from growing thick and directly agglomerating nanoparticles during the drying and calcination process, thereby maintaining the nano-morphology of calcium phosphate particles, improving biological reactivity, and combining the advantages of nano-calcium phosphate and bioglass , in order to overcome the shortcomings of existing bioceramic materials such as large difference in crystal size and crystallinity from natural bone apatite and poor reactivity, while bioglass requires multiple high-temperature calcinations, unstable biological activity, and poor processing performance.