Calcium phosphate biological active ceramic material containing silicon dioxide and preparation method thereof

Abstract

The invention provides a calcium phosphate bioactive ceramic material containing silicon dioxide and a method for preparing the same. The calcium phosphate bioactive ceramic material is prepared by sintering a nanometer calcium phosphate precursor of which the surface is coated with silicon dioxide. The method for preparing the nanometer calcium phosphate bioactive ceramic material containing the silicon dioxide comprises the following steps: synthesizing an aqueous dispersion liquid of the nanometer calcium phosphate precursor by a liquid phase method; adding the aqueous dispersion liquid in to an active silicic acid solution, and controlling the pH value, the temperature and the time of the reaction to condense and gelatinate the active silicic acid into the silicon dioxide coating on the surface of the nanometer calcium phosphate precursor; and finally, performing drying and high temperature calcination to obtain the calcium phosphate bioactive ceramic material containing silicon dioxide. Because the surface of nanometer calcium phosphate precursor is coated with the silicon dioxide, the direct agglomeration in the nanometer calcium phosphate is avoided in the process of drying and calcining, thus the original nanometer scale structure of the nanometer calcium phosphate precursor is kept; at the same time, the silicon dioxide coated on the surfaces of the calcium phosphate particles endows the ceramic material with better interface reactivity in organisms in comparison with the common nanometer calcium phosphate.

Description

technical field [0001] The invention relates to a silicon dioxide-containing calcium phosphate bioactive ceramic material, which is a new type of inorganic biological material used for repairing and filling bone tissue defects in surgical operations. Background technique [0002] Bioceramics have undergone a change process from inert bioceramics such as alumina and zirconia ceramics to degradable bioceramics such as tricalcium phosphate ceramics and bioactive bioceramics such as hydroxyapatite ceramics. In recent years, with the development of regenerative medicine research and tissue engineering technology, there have been higher requirements for the performance of biomaterials. Some scholars have proposed the concept of third-generation biomaterials, and believe that the new generation of biomaterials should have both biological activity and And degradable. Studies have found that some silicon-containing bioglasses have both properties, and their biological activity is re...

AI Technical Summary

Problems solved by technology

During the preparation process, by wrapping silica on the surface of nano-calcium phosphate, the growth and direct aggregation of nano-calcium phosphate nanoparticles during drying and calcination are avoided, the nano-morphology of calcium phosphate particles is maintained, and the biological reactivity is improved. With the advantages of nano-calcium phosphate and bioglass, it is expected to overcome the large difference in crystal size and crystallinity between existing bioceramic materials and natural bone apatite, and poor reactivity, while bioglass needs multiple high-temperature calcinations, and its biological activity is unstable. And the disadvantage of poor processing performance