Pharmaceutical formulation of Chinese white olive for relieving cough and preparation method thereof

A pharmaceutical preparation and a drug technology are applied in the field of pharmaceutical preparations and preparations of Qingguo for relieving cough, which can solve the problems that diabetics are not suitable for long-term use, low level of production automation, and cannot be swallowed whole pills, etc., and achieves convenient storage and bioavailability. Good, hygienic and easy-to-use effects

Inactive Publication Date: 2009-04-22
BEIJING TONGRENTANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of traditional Chinese medicine big honey pill is backward, the level of production automation is low, the dosage is large, the taste is not good, and it cannot be swallowed as a whole pill, the absorption is slow, and there are reasons such as diabetes patients should not take it for a long time, which greatly limits the number of people who take it. However, the formulation of this prescription is reasonable, and it is well-known in the international and domestic markets. Even though other factors such as dosage forms lag behind the development of modern medicine, it still retains an important place in the industry.

Method used

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  • Pharmaceutical formulation of Chinese white olive for relieving cough and preparation method thereof
  • Pharmaceutical formulation of Chinese white olive for relieving cough and preparation method thereof
  • Pharmaceutical formulation of Chinese white olive for relieving cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Example 1: Qingguo tablets for cough relief

[0148] Prescription: Western green fruit 135g, ephedra 45g, bitter almond (peeled and fried) 79g, gypsum 22.6g, licorice 29.3g, perilla seed (stir-fried) 169g, perilla leaf 67.7g, pinellia (made) 271g, fritillaria 67.7g, Morus alba (honey) 90g, ginkgo kernel 225.6g, scutellaria baicalensis 90g, coltsfoot flower 67.7g and borneol 8.1g.

[0149] Preparation method: the above three flavors of ephedra, ginkgo kernel, and Fritillaria, add 8 times the amount of 50% ethanol, decoct three times, one hour each time, combine the decoction, filter, recover the ethanol under reduced pressure until there is no alcohol smell, concentrate to a relative Clear ointment with a density of 1.20 (50°C), set aside; add 10 times the amount of water to the remaining eleven flavors except borneol, decoct three times, one hour each time, combine the decoction, filter, and concentrate to a relative density of 1.20 (50°C) ℃) clear ointment; add the ab...

Embodiment 2

[0150] Example 2: Zhisou Qingguo Granules

[0151] Prescription: Western green fruit 135g, ephedra 45g, bitter almond (peeled and fried) 79g, gypsum 22.6g, licorice 29.3g, perilla seed (stir-fried) 169g, perilla leaf 67.7g, pinellia (made) 271g, fritillaria 67.7g, Morus alba (honey) 90g, ginkgo kernel 225.6g, scutellaria baicalensis 90g, coltsfoot flower 67.7g and borneol 8.1g.

[0152] Preparation method: the above three flavors of ephedra, ginkgo kernel, and fritillaria, add 10 times the amount of 70% ethanol, decoct twice, 1.5 hours each time, combine the decoction, filter, recover ethanol under reduced pressure until it has no alcohol smell, concentrate to Clear ointment with a relative density of 1.20 (50°C), set aside; add 12 times the amount of water to the other eleven flavors except borneol, decoct twice for 1.5 hours each time, combine the decoctions, filter, and concentrate to a relative density of 1.20 (50°C) clear ointment; add the above-mentioned alcohol-extract...

Embodiment 3

[0153] Example 3: Zhisou Qingguo Capsules

[0154] Prescription: Western green fruit 135g, ephedra 45g, bitter almond (peeled and fried) 79g, gypsum 22.6g, licorice 29.3g, perilla seed (stir-fried) 169g, perilla leaf 67.7g, pinellia (made) 271g, fritillaria 67.7g, Morus alba (honey) 90g, ginkgo kernel 225.6g, scutellaria baicalensis 90g, coltsfoot flower 67.7g and borneol 8.1g.

[0155] Preparation method: the above three flavors of ephedra, ginkgo kernel, and fritillaria, add 10 times the amount of 50% ethanol, decoct three times, 1.5 hours each time, combine the decoction, filter, recover the ethanol under reduced pressure until it has no alcohol smell, concentrate to a relative Clear paste with a density of 1.20 (50°C), set aside; add 8 times the amount of water to the remaining eleven flavors except borneol, decoct three times, one hour each time, combine the decoction, filter, and concentrate to a relative density of 1.20 (50°C) ℃) clear paste; add the above-mentioned al...

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Abstract

The invention provides a medicine preparation of fructus canarii for relieving cough. The medicine preparation comprises medicine compositions and medicine auxiliary materials; the medicine compositions consist of the following raw materials in weight portion: Fructus chebulae immaturus, herba ephedrae, semen armeniacae amara, gypsum, liquorice, perillae, folia perillae acutae, rhizoma pinelliae, fritillaria thunbergii miq, cortex mori radicis, semen ginkgo meat, scutellaria, flos farfarae and borneol. The medicine preparation comprises all the compositions of a traditional formula, keeps the fixed mixture ratio of the raw material compositions of the original formula, has unchanged curative effect and better dissolution rate and bioavailability than the prior honeyed pill preparation, is convenient to take, carry, store and the like and is easy to widely apply.

Description

technical field [0001] The invention relates to a new drug dosage form containing all the components and ratios of Zhisou Qingguo Pill, that is, the invention relates to a pharmaceutical preparation of Zhisou Qingguo and a preparation method thereof. Background technique [0002] The current Zhisou Qingguo Pill (standard number WS3-B-1897-95) is a compound preparation of traditional Chinese medicine, and its functions and indications are clearing the lung and resolving phlegm, relieving cough and relieving asthma. It is used for cough with excessive phlegm caused by wind-cold constriction of the lungs, fullness of the chest and diaphragm, shortness of breath and wheezing, dry mouth and throat. The main ingredients of Zhisou Qingguo Pill are: Xiqingguo, ephedra, bitter almond, gypsum, licorice, perilla seed, perilla leaf, pinellia, fritillaria, mulberry bark, ginkgo kernel, scutellaria baicalensis, coltsfoot flower, borneol. In the prescription, Qingguo clears the lungs, cle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/16A61K9/20A61K9/48A61P11/14A61K31/045A61K33/06
Inventor 范国强王海贾俊
Owner BEIJING TONGRENTANG CO LTD
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