Gelatin/calcium phosphate asymmetry medicine releasing coating layer and preparation method thereof

A calcium phosphate, asymmetric technology, applied in coating, medical science, prosthesis, etc., can solve the problem of not achieving uniform drug release, and achieve the effect of reducing bacterial infection rate, preventing and treating postoperative infection

Inactive Publication Date: 2009-04-29
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, because the general gelatin/calcium phosphate coating can not achieve the effect of uniform drug release, therefore,...

Method used

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  • Gelatin/calcium phosphate asymmetry medicine releasing coating layer and preparation method thereof
  • Gelatin/calcium phosphate asymmetry medicine releasing coating layer and preparation method thereof
  • Gelatin/calcium phosphate asymmetry medicine releasing coating layer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A Ti-6Al-4V alloy sheet (50mm×20mm×1mm) was used as the substrate. Before coating, the substrate was polished with silicon carbide sandpaper (400-4000), and ultrasonically cleaned in acetone, ethanol and deionized water for 15 minutes. Then soak in a solution containing 2ml HF, 4ml HNO 3 and 1000ml deionized water solution for passivation for 10 minutes, washed with water, and dried. Formulated with 0.5M Ca(NO 3 ) 2 , an aqueous solution of 1% (W / W) PEG-2000, and the pH value of the solution was adjusted to 10 with ammonia water. Prepare 0.5M (NH 4 ) 2 HPO 4 aqueous solution, and the pH of the solution was adjusted to 10 with ammonia water. Subsequently, the diammonium hydrogen phosphate solution was slowly added dropwise to the calcium nitrate solution with vigorous stirring, and the Ca / P molar ratio was maintained at 1.67. After the diammonium hydrogen phosphate solution was added dropwise, the reaction solution continued to age for 3 hours. Finally, the prod...

Embodiment 2

[0047] Ti-6Al-4V alloy sheet (50mm×20mm×1mm) was used as the substrate. Before coating, the substrate was polished with silicon carbide sandpaper (400-4000), and ultrasonically cleaned in acetone, ethanol and deionized water for 15 minutes. Then soak in the water containing 2mlHF, 4mlHNO 3 and 1000ml deionized water solution for passivation for 10 minutes, washed with water, and dried. Formulated with 0.5M Ca(NO 3 ) 2 , an aqueous solution of 1% (W / W) PEG-2000, and the pH value of the solution was adjusted to 10 with ammonia water. Prepare 0.5M (NH 4 ) 2 HPO 4 aqueous solution, and the pH of the solution was adjusted to 10 with ammonia water. Subsequently, the diammonium hydrogen phosphate solution was slowly added dropwise to the calcium nitrate solution with vigorous stirring, and the Ca / P molar ratio was maintained at 1.67. After the dropwise addition, the product was filtered, washed 3 times with water, and washed 2 times with ethanol. The filter cake was placed in...

Embodiment 3

[0052] A Ti-15Mo alloy sheet (50mm×20mm×1mm) was used as the substrate. Before coating, the substrate was polished with silicon carbide sandpaper (400-4000), and ultrasonically cleaned in acetone, ethanol and deionized water for 15 minutes. Then soak in the water containing 2mlHF, 4mlHNO 3 and 1000ml deionized water solution for passivation for 10 minutes, washed with water, and dried. Formulated with 0.5M Ca(NO 3 ) 2 , an aqueous solution of 1% (W / W) PEG-2000, and the pH value of the solution was adjusted to 10 with ammonia water. Prepare 0.5M (NH 4 ) 2 HPO 4aqueous solution, and the pH of the solution was adjusted to 10 with ammonia water. Subsequently, the diammonium hydrogen phosphate solution was slowly added dropwise to the calcium nitrate solution with vigorous stirring, and the Ca / P molar ratio was maintained at 1.67. After the diammonium hydrogen phosphate solution was added dropwise, the reaction solution continued to age for 3 hours. Finally, the product wa...

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Abstract

The invention relates to a gelatin/calcium phosphate asymmetric drug release coating and a preparation method thereof, belonging to the field of biological coating material. The preparation method takes medical Ti alloy or Co alloy sheet as a matrix, takes gelatin and calcium phosphate as raw materials, and forms an asymmetric coating on the matrix by the methods of CZ (czochralski) and phase separation. The gelatin/calcium phosphate asymmetric drug release coating has thickness ranging from 30 microns to 300 microns and is divided into two layers: a compact external layer and a porous internal layer; wherein, the thickness of the compact external layer is 3-30 microns and the porous internal layer has the porosity of 20-80 percent; and the mass ratio between the gelatin and calcium phosphate is 5-50. The coating can control hydrophobic drug to release at a constant speed, thus achieving the object of ideally releasing and controlling the drug, effectively preventing and curing postoperative infection and reducing bacteria infection rates. Compared with the pure gelatin layers and the naked medical Ti alloy surface, the coating can induce the deposition of the calcium phosphate on the surface of the coating more quickly.

Description

technical field [0001] The invention relates to a gelatin / calcium phosphate asymmetric drug release coating and a preparation method thereof, belonging to the field of biological coating materials. Background technique [0002] Drug coatings have a wide range of applications in pharmaceutical processes. Most drug coatings are prepared by dissolving or dispersing active ingredients in the coating to achieve controlled release. In these drug coatings, the drug release is mainly divided into two stages: the first is the initial stage of rapid drug release, and then the long-term slow drug release stage. It is well known that continuous release below the minimum inhibitory concentration will cause the organism to develop drug resistance, so the most suitable release method is to release the drug at a stable rate at a drug concentration higher than the minimum inhibitory concentration. It has been reported that the drug release rate is constant when the driving force of release...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/06A61L27/04A61L27/54
Inventor 祝迎春赵东辉肖军武李芳
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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