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Uses of modified polysaccharide rich ingalactose in medicament for treating inflammatory bowel diseases

A technology for inflammatory bowel disease and therapeutic drugs, applied in the field of application of galactose-rich modified polysaccharides in inflammatory bowel disease therapeutic drugs, can solve the problem of inflammatory bowel disease without targeting galectin-3, and achieve Good curative effect, promote damage repair, inhibit cell apoptosis

Inactive Publication Date: 2009-05-13
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, in the prior art, there is no effective method and suitable drug targeting galectin-3 for the treatment of inflammatory bowel disease

Method used

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  • Uses of modified polysaccharide rich ingalactose in medicament for treating inflammatory bowel diseases
  • Uses of modified polysaccharide rich ingalactose in medicament for treating inflammatory bowel diseases

Examples

Experimental program
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preparation example Construction

[0029] The preparation method of the modified natural gum is: subjecting pectin, guar gum and locust bean gum to enzymatic hydrolysis (pH=4-5), or alkali (pH=9-10) and acid (pH=3-5 ) hydrolysis, or sodium borohydride reduction, or after methanol saponification, alcohol precipitation, dialysis, and galactosidase enzymatic hydrolysis (pH=4-6, 37°C) to expose terminal galactose, after alcohol precipitation, dialysis, concentration, Freeze-dried to obtain modified natural gum. Adopt gel chromatography or molecular weight cut-off method, obtain the galactose-containing natural gum of target molecular weight (5000-50000Da);

[0030] The extraction method of the modified plant polysaccharide is as follows: crushing aloe, medlar, apple, jujube or rhubarb, refluxing ethanol to remove fat-soluble components, refluxing water, ethanol precipitation, dialysis, concentration and freeze-drying to obtain crude polysaccharide; The crude polysaccharide is hydrolyzed with galactosidase (pH=4-6,...

Embodiment 1

[0033] Take 100g of pectin, after slightly moistening, incubate with pectinase at 37°C for 4 hours (pH=4-6), adjust the pH value to neutral, overnight, use HPLC to detect the degree of esterification, alcohol precipitation, dialysis, and molecular weight determination. Gel chromatography or molecular weight cut-off to obtain galactose-containing pectin with a molecular weight of 5000-50000Da.

Embodiment 2

[0035] Take 100g of guar gum, after slightly moistening, reflux for 4 hours (pH = 9-10), adjust the pH value to neutral, overnight, and then reflux for 2 hours (pH = 3-4), alcohol precipitation, dialysis, concentration, freezing Dry. It was hydrolyzed by galactosidase (pH=4-6, 37°C), alcohol precipitation, dialysis, concentration and lyophilization. The galactose-containing guar gum with target molecular weight (5000-50000 Da) was obtained by gel chromatography or molecular weight cutoff.

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Abstract

The invention relates to the application of modified polysaccharide rich in galactose in medical preparation, in particular to application of modified polysaccharide rich in galactose in medicines for preventing and treating inflammatory bowel diseases. Aiming to fill the blank of preventing and treating inflammatory bowel disease by targeted gm-3-TLR4 access, the invention provides the technical scheme of the application of modified polysaccharide rich in galactose in treating inflammatory bowel disease, and the modified polysaccharide rich in galactose comprises natural gum or plant polysaccharide. The invention has the advantages that galectin-3 is used as the acting target, and the change of TLR4 in IBD is influenced through the regulation of the change of galectin-3, thereby promoting cell multiplication, inhibiting apoptosis and promoting injury repair. By adopting modified polysaccharide rich in galactose to treat colitis, the efficacy is good, high expression of galectin-3 can be induced, and the injury repair can be promoted; therefore, the side effect is small, and the modified polysaccharide rich in galactose can be used for a long term.

Description

technical field [0001] The invention relates to the application of modified polysaccharide rich in galactose in medicine preparation, in particular to the application of modified polysaccharide rich in galactose in medicine for preventing and treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a type of autoimmune disease related to immune disorders, flora disorders and genetic factors, characterized by non-specific inflammatory reactions and ulcer formation in the colonic mucosa ; With abdominal pain, diarrhea, mucus stool, pus and blood in the stool, repeated attacks, protracted healing as the clinical manifestations. In European and American countries, the incidence of IBD is as high as 200-300 / 100,000 [1]; in Asia, including my country's Hong Kong and Shanghai, it is showing a rapid upward trend [2]. In recent years, the intake of high-calorie, high-protein and low-fibe...

Claims

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Application Information

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IPC IPC(8): A61K31/732A61K31/715A61P1/00
Inventor 刘莉梅其炳孙阳李宇华李晨
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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